A5015138770- Management of metastatic bone disease
- Brain Metastases and Treatment
- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Medical Imaging Techniques and Applications
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Memory and Neural Mechanisms
- Lung Cancer Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging and Analysis
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Ultrasound and Hyperthermia Applications
- Lanthanide and Transition Metal Complexes
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
University of Toronto
2016-2025
Sunnybrook Health Science Centre
2016-2025
Health Sciences Centre
2016-2025
Sunnybrook Hospital
2012-2025
Princess Margaret Cancer Centre
2013-2024
Canada Research Chairs
2016-2024
Sunnybrook Research Institute
2015-2024
Novartis (Germany)
2024
Roche (Switzerland)
2024
Seagen (Canada)
2024
Glioblastoma is associated with a poor prognosis in the elderly. Survival has been shown to increase among patients 70 years of age or younger when temozolomide chemotherapy added standard radiotherapy (60 Gy over period 6 weeks). In elderly patients, more convenient shorter courses are commonly used, but benefit adding course unknown.We conducted trial involving 65 older newly diagnosed glioblastoma. Patients were randomly assigned receive either alone (40 15 fractions) concomitant and...
Abstract The blood-brain barrier (BBB) has long limited therapeutic access to brain tumor and peritumoral tissue. In animals, MR-guided focused ultrasound (MRgFUS) with intravenously injected microbubbles can temporarily repeatedly disrupt the BBB in a targeted fashion, without open surgery. Our objective is demonstrate safety feasibility of MRgFUS opening systemically administered chemotherapy patients glioma phase I, single-arm, open-label study. Five previously confirmed or suspected...
Vertebral compression fracture (VCF) is increasingly recognized as an adverse event after spine stereotactic body radiotherapy (SBRT). We report a multi-institutional study aimed at clarifying the risk and predictive factors associated with VCF.A total of 252 patients 410 spinal segments treated SBRT were included. The primary outcome was development VCF (a new or progression baseline VCF). In addition to various patient-, treatment-, tumor-specific factors, Spinal Instability Neoplastic...
Conventional wisdom has rendered patients with brain metastases ineligible for clinical trials fear that poor survival could mask the benefit of otherwise promising treatments. Our group previously published diagnosis-specific Graded Prognostic Assessment (GPA). Updates larger contemporary cohorts using molecular markers and newly identified prognostic factors have been published. The purposes this work are to present all updated indices in a single report guide treatment choice, stratify...
Although surgery is used increasingly as a strategy to complement treatment with radiation and chemotherapy in patients metastatic epidural spinal cord compression (MESCC), the impact of on health-related quality life (HRQoL) not well established. We aimed prospectively evaluate survival, neurologic, functional, HRQoL outcomes MESCC who underwent surgical management.One hundred forty-two single symptomatic lesion were treated surgically enrolled onto prospective North American multicenter...