A5005150991- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Management of metastatic bone disease
- Head and Neck Cancer Studies
- Prostate Cancer Treatment and Research
- Lung Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Advances in Oncology and Radiotherapy
- Endometrial and Cervical Cancer Treatments
- Brain Metastases and Treatment
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Clinical practice guidelines implementation
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Patient Satisfaction in Healthcare
- Global Cancer Incidence and Screening
- Melanoma and MAPK Pathways
- Patient-Provider Communication in Healthcare
- Urologic and reproductive health conditions
- Adrenal and Paraganglionic Tumors
- Spinal Fractures and Fixation Techniques
- AI in cancer detection
Scripps MD Anderson Cancer Center
2022-2024
The University of Texas MD Anderson Cancer Center
2017-2023
University of California, Irvine
2013-2017
University of California, Los Angeles
2015
UC Irvine Health
2013-2014
Radiation Oncology Associates
2013-2014
Angeles Clinic and Research Institute
2013
Conventional wisdom has rendered patients with brain metastases ineligible for clinical trials fear that poor survival could mask the benefit of otherwise promising treatments. Our group previously published diagnosis-specific Graded Prognostic Assessment (GPA). Updates larger contemporary cohorts using molecular markers and newly identified prognostic factors have been published. The purposes this work are to present all updated indices in a single report guide treatment choice, stratify...
Breast cancer treatment is based on estrogen receptors (ERs), progesterone (PRs), and human epidermal growth factor receptor 2 (HER2). At the time of metastasis, status can be discordant from that at initial diagnosis. The purpose this study was to determine incidence discordance its effect survival subsequent in patients with breast brain metastases (BCBM).A retrospective database 316 who underwent craniotomy for BCBM between 2006 2017 created. Discordance considered present if ER, PR, or...
Objectives We report single-institution clinical outcomes of women treated with stereotactic ablative radiotherapy (SABR) for oligometastatic or progressive gynecological malignancies. Materials and Methods From 2009 to 2015, 47 lesions from 28 patients were SABR retrospectively analyzed. All had (93%) oligoprogressive (7%) disease. Primary cancer diagnoses 15 ovarian, 8 endometrial, 2 cervical, vaginal, 1 uterine carcinosarcoma. Treatment was delivered using a median 5 fractions total dose...
This study was an open-label multicenter phase II trial to investigate the efficacy and safety of nab-paclitaxel bevacizumab as first-line therapy in patients with histologically confirmed unresectable metastatic melanoma.The treatment regimen consisted a 28-day cycle which received nab-paclitaxel, 150 mg/m through intravenous (IV) infusion weekly for 3 weeks bevacizumab, 10 mg/kg IV every 2 without rest period. The repeated until there unacceptable toxicity or disease progression. If 1 drug...
Abstract Background In order to accurately accumulate delivered dose for head and neck cancer patients treated with the Adapt Position workflow on 1.5T magnetic resonance imaging (MRI)‐linear accelerator (MR‐linac), low‐resolution T2‐weighted MRIs used daily setup must be segmented enable reconstruction of at each fraction. Purpose this pilot study, we evaluate various autosegmentation methods organs risk (OARs) on‐board from MR‐linac off‐line dose. Methods Seven OARs (parotid glands,...
To quantify Gleason score (GS) heterogeneity within multiparametric magnetic resonance imaging (MRI)-targeted prostate biopsies and to determine impact on National Comprehensive Cancer Network (NCCN) risk stratification.
PURPOSE Clinical efficiency is a key component of value-based health care. Our objective here was to identify workflow inefficiencies by using time-driven activity-based costing (TDABC) and evaluate the implementation new clinical in high-volume outpatient radiation oncology clinics. METHODS quality improvement study conducted with Departments GI, Genitourinary (GU), Thoracic Radiation Oncology at large academic cancer center four community network sites. TDABC used create process maps...
The aim of this study was to determine if correlations exist between quantitative parameters from dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) MRI with National Comprehensive Cancer Network (NCCN) risk group, Gleason score (GS), maximum tumour diameter (MTD), pre-treatment prostate-specific antigen (PSA), clinical T stage prostate volume in cancer.We retrospectively reviewed 3T multiparametric reports on biopsy-proven cancer patients performed during radiation treatment...
Background: Ki-67 is a robust predictive/prognostic marker in prostate cancer; however, tumor heterogeneity biopsy samples not well studied. Methods: Using an MRI/US fusion device, cores were obtained systematically and by targeting when indicated MRI. Prostate containing cancer from 77 consecutive men analyzed. The highest was used to determine interprostatic variation. range (highest minus lowest) intraprostatic intralesion Apparent diffusion coefficient (ADC) values evaluated relation...
PURPOSE: Several treatment options for spinal metastases exist, including multiple radiation therapy (RT) techniques: three-dimensional (3D) conventional RT (3D-RT), intensity-modulated (IMRT), and spine stereotactic radiosurgery (SSRS). Although data exist regarding reimbursement differences across regimens, in provider care delivery costs have yet to be evaluated. We quantified institutional associated with metastases, using a time-driven activity-based costing model. METHODS: Comparisons...
Consolidative radiotherapy (RT) has been shown to improve overall survival in oligometastatic non-small cell lung cancer (NSCLC), as demonstrated by a growing number of prospective trials.We quantified the costs delivery consolidative RT for common clinical pathways associated with treating NSCLC, applying time-driven activity-based costing (TDABC) methodology.Full cycle were evaluated 4 treatment regimens: (Regimen #1) 10-fraction 3D conformal radiation therapy (3D-CRT) palliation distant...
Abstract Purpose In order to accurately accumulate delivered dose for head and neck cancer patients treated with the Adapt Position workflow on 1.5T magnetic resonance imaging (MRI)-linear accelerator (MR-linac), low-resolution T2-weighted MRIs used daily setup must be segmented enable reconstruction of at each fraction. this study, our goal is evaluate various autosegmentation methods organs risk (OARs) on-board from MR-linac off-line dose. Methods Seven OARs (parotid glands, submandibular...
Clinical efficiency is a key component of the value-based care model and driver patient satisfaction. The purpose this study was to identify address inefficiencies at high-volume radiation oncology clinic.Patient flow analysis (PFA) used create process maps optimize workflow consultation visits in gastrointestinal clinic large academic cancer center. Metrics such as cycle times, waiting rooming times were assessed by using real-time status function electronic medical record for 556 consults...