A5069874449- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Effects of Radiation Exposure
- Management of metastatic bone disease
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Ultrasound and Hyperthermia Applications
- Lung Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Urologic and reproductive health conditions
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Lung Cancer Treatments and Mutations
- TGF-β signaling in diseases
- Economic and Financial Impacts of Cancer
- Head and Neck Cancer Studies
- Breast Cancer Treatment Studies
- Palliative Care and End-of-Life Issues
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Statistical Methods in Clinical Trials
- Advanced X-ray and CT Imaging
Virginia Commonwealth University
2012-2022
United States Food and Drug Administration
2020-2022
The University of Texas MD Anderson Cancer Center
2007-2021
Center for Drug Evaluation and Research
2020-2021
Virginia Commonwealth University Medical Center
2009-2020
University Health System
2020
Medical Cañada (Spain)
2020
Varian Medical Systems (Germany)
2018
Novartis (China)
2018
VCU Massey Comprehensive Cancer Center
2018
An increasing serum prostate-specific antigen (PSA) level is the initial sign of recurrent prostate cancer among patients treated with radical prostatectomy. Salvage radiation therapy (SRT) may eradicate locally cancer, but studies to distinguish local from systemic recurrence lack adequate sensitivity and specificity. We developed a nomogram predict probability control at 6 years after SRT for PSA-defined recurrence.Using multivariable Cox regression analysis, we constructed model disease...
We aimed to update a previously published, multi-institutional nomogram of outcomes for salvage radiotherapy (SRT) following radical prostatectomy (RP) prostate cancer, including patients treated in the contemporary era.Individual data from node-negative with detectable post-RP prostate-specific antigen (PSA) SRT or without concurrent androgen-deprivation therapy (ADT) were obtained 10 academic institutions. Freedom biochemical failure (FFBF) and distant metastases (DM) rates estimated,...
Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or damaged cells. Induction cell also one underlying mechanisms by which cancer therapies exert antitumor activity. However, increasing body evidence from preclinical studies demonstrates radiation and chemotherapy cause accumulation senescent cells (SnCs) both in normal tissue. SnCs tumors can, paradoxically, promote relapse, metastasis,...
<h3>Importance</h3> Immune checkpoint inhibitors (ICIs) and radiation therapy (RT) are widely used to treat various cancers, but little data available guide clinicians on ICI use sequentially with RT. <h3>Objective</h3> To assess whether there is an increased risk of serious adverse events (AEs) associated RT given within 90 days prior ICI. <h3>Design, Setting, Participants</h3> Individual patient were pooled from 68 prospective trials ICIs submitted in initial or supplemental licensing...
Hepatic veno-occlusive disease and idiopathic interstitial pneumonitis are major causes of morbidity mortality after bone marrow transplantation. Fibrosis is a characteristic both conditions, transforming growth factor β (TGFβ) has been implicated in the pathogenesis fibrosis.
Objective In this study, the impact of preoperative chemotherapy and radiation on histopathology a subgroup patients with rectal adenocarcinoma was examined. As well, survival, disease-free survival pelvic recurrence rates were examined, compared concurrent control group. Summary Background Data The optimal treatment large carcinomas remains controversial; current therapy usually involves abdominoperineal resection plus postoperative chemoradiation; combination can be associated significant...
To develop approaches to prophylaxis/protection, mitigation and treatment of radiation injuries, appropriate models are needed that integrate the complex events occur in radiation-exposed organism. While spectrum agents clinical use or preclinical development is limited, new research findings promise improvements survival after whole-body irradiation reductions risk adverse effects radiotherapy. Approaches include act on initial radiochemical events, prevent reduce progression damage,...
The authors determined whether untreated breast cancer patients have elevated plasma levels of transforming growth factor-beta 1 (TGF-beta 1).Increased TGF-beta recently were found after chemotherapy in with advanced cancer. However, it currently is unknown this elevation caused by chemotherapy-induced normal tissue damage or results from the presence tumor.An enzyme-linked immunosorbent assay was used to measure 26 newly diagnosed before and definitive surgery. Patients grouped...
No AccessJournal of Urology1 Dec 1987Postoperative Radiotherapy for Patients with Carcinoma the Prostate Undergoing Radical Prostatectomy Positive Surgical Margins, Seminal Vesicle Involvement and/or Penetration Through Capsule Mitchell S. Anscher, and Leonard R. Prosnitz AnscherMitchell Anscher More articles by this author , ProsnitzLeonard View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)43656-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack...
We conducted a randomized, double-blind clinical trial of atenolol as compared with placebo in the treatment patients hospitalized alcohol withdrawal syndrome. In addition to receiving customary therapy, 61 were randomly assigned receive atenolol, and 59 placebo. Outcome was assessed daily by measurement nine features three categories: vital signs, signs (e.g., tremor), behavioral agitation anxiety). Compared patients, had significant reduction mean length hospital stay (four five days, P...
With advances in the understanding of histopathology on outcome, accurate meningioma grading becomes critical and drives treatment selection. The 2000 2007 WHO schema greatly increased proportion grade II meningiomas. Although associations with progression-free survival (PFS) overall (OS) have been independently validated, interobserver concordance has not formally assessed. Once mature, NRG Oncology RTOG-0539 will report PFS OS variably treated low-, intermediate-, high-risk cohorts. We...