A5051784988- MicroRNA in disease regulation
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Marine Toxins and Detection Methods
- Atherosclerosis and Cardiovascular Diseases
- Nicotinic Acetylcholine Receptors Study
- Advanced Radiotherapy Techniques
- Biomedical Text Mining and Ontologies
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Neuroscience of respiration and sleep
- Head and Neck Cancer Studies
- Ion channel regulation and function
- Brain Metastases and Treatment
- Cancer-related molecular mechanisms research
- Peroxisome Proliferator-Activated Receptors
- Extracellular vesicles in disease
- Biomarkers in Disease Mechanisms
- Complementary and Alternative Medicine Studies
- Genetics, Bioinformatics, and Biomedical Research
- Inflammatory Biomarkers in Disease Prognosis
- Lipoproteins and Cardiovascular Health
- Obesity and Health Practices
- Acute Kidney Injury Research
- Obesity, Physical Activity, Diet
Nanfang Hospital
2015-2024
Soochow University
2017-2024
Southern Medical University
2015-2024
National Cancer Institute
2004-2024
National Institutes of Health
1999-2023
National Center for Complementary and Integrative Health
2009-2023
The First People's Hospital of Changzhou
2017-2022
Weatherford College
2021
Creative Commons
2021
Weifang University
2018-2020
Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or damaged cells. Induction cell also one underlying mechanisms by which cancer therapies exert antitumor activity. However, increasing body evidence from preclinical studies demonstrates radiation and chemotherapy cause accumulation senescent cells (SnCs) both in normal tissue. SnCs tumors can, paradoxically, promote relapse, metastasis,...
The Systemic Inflammation Response Index (SIRI), based on peripheral lymphocyte, neutrophil, and monocyte counts, was recently investigated as a prognostic marker for several tumors. However, use of the SIRI has not been reported nasopharyngeal carcinoma (NPC). We evaluated value in primary validation cohorts. also established an effective nomogram NPC clinicopathological parameters SIRI. predictive accuracy discriminative ability were determined using concordance index (C-index) calibration...
While great interest in health effects of natural product (NP) including dietary supplements and foods persists, promising preclinical NP research is not consistently translating into actionable clinical trial (CT) outcomes. Generally considered the gold standard for assessing safety efficacy, CTs, especially phase III are costly require rigorous planning to optimize value information obtained. More effective bridging from CT was goal a September, 2018 transdisciplinary workshop....
Systemic immune-inflammation index (SII), based on peripheral lymphocyte, neutrophil, and platelet counts, was recently investigated as a prognostic marker in several tumors. However, SII has not been reported nasopharyngeal carcinoma (NPC). We evaluated the value of 327 patients with NPC. Univariate multivariate analyses were calculated by Cox proportional hazards regression model. The time-dependent receiver operating characteristics (ROC) curve used to compare discrimination ability for...
Oxytocin (OT) and vasopressin (VP) are peptide hormones that derived from genes predominantly expressed in distinct magnocellular neurons the paraventricular (PVN) supraoptic (SON) nuclei of hypothalamus. Recent evidence suggests some coexpress both peptides. Our qualitative RT-PCR experiments on single cells show majority messenger RNAs (mRNAs) varying amounts. Using a competitive method combined with standard calibration curve, we quantitatively determined OT VP mRNA normal female rat SON,...
Domoic acid induces a time-dependent neuroexcitotoxic effect in neonatal rats characterized hyperactivity, stereotypic scratching, convulsions, and death with observable behaviors occurring at exposures 40 times lower by body weight neonates than reported adults. Low doses of domoic (0.1 mg/kg) induced c-fos the central nervous system which was inhibited part 2-amino-5-phosphonovaleric acid, an NMDA receptor antagonist. caused no evidence structural alteration brain as assessed Nissel...
Abstract Tamoxifen, a member of the selective estrogen receptor modulator (SERM) family, is widely used in treatment (ER)-expressing breast cancer. It has previously been shown that high-dose tamoxifen cytotoxic activity against glioma cells, but whether this effect drug specific or represents general property SERMs unknown. In study, we demonstrate and CC-8490, novel benzopyranone with SERM activity, induce cell apoptosis dose- time-dependent manner. Moreover, administration CC-8490...
Hypoxia-induced cardiomyocyte apoptosis contributes significantly to the development of numerous cardiac diseases, such as ischemic heart disease, failure, etc. Promoting cell survival by inhibiting is one available strategies attenuate dysfunction caused loss. Previous studies have been demonstrated that miR-138 and lipocalin-2 (Lcn2) play important roles in survival. We presently determined whether Lcn2 a target gene involved hypoxia-induced apoptosis. Firstly, mimics were transfected into...
IntroductionNutrition health disparities include differences in incidence, prevalence, morbidity, and mortality of diet-related diseases conditions. Often, race, ethnicity, the social determinants are associated with dietary intake related disparities. This report describes nutrition research supported by NIH over past decade offers future opportunities relevant to NIH's mission as described Strategic Plan for Nutrition Research.MethodsData were extracted from an internal reporting system...
DOMOIC acid (50 nM) elevates cytosolic free calcium ([Ca2+]i) levels in 49% of the hippocampal pyramidal neurons isolated from postnatal day one (PND1) rats. This effect was prevented by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; an antagonist non-N-methyl-D-aspartate (NMDA) receptors, but not 2-amino-5-phosphonovaleric (AP-5; NMDA receptors). Domoic given at 5 μM also elevated [Ca2+]i a second population (36%) which only partially inhibited 100 CNQX. Nimodipine 300 nM elevation caused 50...
Background: A hallmark of atherosclerosis is the formation macrophage-derived foam cells.Serum amyloid P component (SAP), a member pentraxin family proteins, known to affect macrophage activation.However, role SAP in still unclear.Methods: Apolipoprotein E-deficient (Apoe -/-) mice fed high-fat diet were given intraperitoneal injections (6 mg/kg) every other day for total 2 weeks characterize development. Results:We showed that injection attenuated Apoe -/- mice.Immunostaining aortic roots...
Abstract Background CircRNAs play crucial roles in multiple tumours. However, the functions of most circRNAs cervical cancer remain unclear. Methods This study collected GSE113696 data from GEO database to search for differentially expressed cancer. Quantitative reverse transcription PCR was used detect expression level circNEIL3 cells and tissues. Then, functional experiments vitro vivo were performed evaluate effects Results CircNEIL3 highly In verified that enhanced proliferation capacity...
Maitotoxin (MTX) is a water-soluble polyether, isolated from the marine dinoflagellate Gambierdiscus toxicus, that stimulates hormone release and Ca2+ influx. We have investigated action by which MTX induces influx prolactin (PRL) GH4C1 rat pituitary cells. PRL elicited abolished in concentration-dependent manner nimodipine, dihydropyridine (DHP) antagonist of type L voltage-dependent calcium channels (L-VDCC), indicating MTX-enhanced occurs via activation L-VDCC. As an initial approach to...
Atherosclerosis is one of the common health threats all over world. It a complex heritable disease that affects arterial blood vessels. Chronic inflammatory response plays an important role in atherogenesis. There has been little success fully identifying functionally genes pathogenesis atherosclerosis. In present study, we performed systematic analysis atherosclerosis-related using text mining. We identified total 1312 genes. Gene ontology (GO) revealed 35 terms exhibited significance (p <...
Abstract Previously, we reported that heat shock protein (HSP)65 impairs the effects of high-density lipoprotein on macrophages. We also showed immune response activation adversely affects reverse cholesterol transport (RCT). In this study, investigated Src family kinase lymphocyte-specific tyrosine (Lck) and elucidated mechanism underlying HSP65-regulated efflux in T cells. evaluated cell proliferation, Lck expression, inflammatory cytokine production Jurkat cells CD4+ HSP65-mediated...