A5100752894- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Cancer, Lipids, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Toxoplasma gondii Research Studies
- Natural product bioactivities and synthesis
- Adipokines, Inflammation, and Metabolic Diseases
- RNA Interference and Gene Delivery
- Mycobacterium research and diagnosis
- Bacteriophages and microbial interactions
- Cancer Research and Treatments
- Glutathione Transferases and Polymorphisms
- Molecular Biology Techniques and Applications
- Cholesterol and Lipid Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
Zhujiang Hospital
2018-2024
Southern Medical University
2018-2024
Nanfang Hospital
2018-2021
Shanghai Jiao Tong University
2021
Jinzhou Medical University
2021
Renji Hospital
2021
XinHua Hospital
2021
307th Hospital of Chinese People’s Liberation Army
2019
National Research Institute of Brewing
2019
Fudan University Shanghai Cancer Center
2016-2019
Abstract While long noncoding RNAs (lncRNAs) have been reported to play an important role in human cancer types, they remain poorly understood papillary thyroid carcinoma (PTC). The aim of this study was use genome-wide expression profiling identify lncRNAs acting as competing endogenous (ceRNAs) PTC. We constructed a ceRNA network based on our lncRNA microarray data and validated the correlation between myocardial infarction-associated transcript (MIAT), miRNA-150-5p, EZH2 vitro vivo. found...
// Tian Liao 1, * , Ning Qu Rong-Liang Shi 2, Kai Guo 1 Ben Ma Yi-Ming Cao Jun Xiang Zhong-Wu Lu Yong-Xue Zhu Duan-Shu Li Qing-Hai Ji Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Oncology, Medical College, University, Shanghai, 200032, China 2 General Minhang Hospital, 201199, These authors contributed equally to this work Correspondence to: JI, email: jiqinghai@shca.org.cn Keywords: papillary thyroid cancer, BRAF, lncRNA, proliferation, migration Received:...
The plasmacytoma variant translocation 1 gene (PVT1) is a large non-coding locus at adjacent of c-Myc, and long RNA PVT1 now recognized as cancerous co-amplified with c-Myc in various cancers. But the expression functional role colorectal cancer are still unelucidated. In addition, all reported RNAs so far discovered either cells or tissues, but no research about detection extracellular vesicles has been yet. present study, we firstly investigated specimens its correlation other related...
Abstract Background Non-small cell lung cancer (NSCLC) is the most common tumor with severe morbidity and high mortality. Long non-coding RNAs (lncRNAs) as crucial regulators participate in multiple progressions. However, role of lncRNA MEG8 development NSCLC remains unclear. Here, we aimed to investigate effect on progression underlying mechanism. Methods Cell proliferation was analyzed by EdU assays. The impacts MEG8, miR-15a-5p, miR-15b-5p invasion migration were assessed transwell assay....
Given the heterogeneity of tumors, there is an urgent need for accurate prognostic parameters in prostate cancer (PCa) patients.Lipid metabolism (LM) reprogramming and oxidative stress (OS) play a vital role progression PCa.In this work, we identified five LM-OS-related genes (including ACOX2, PPRAGC1A, PTGS1, PTGS2, HAO1) associated with biochemical recurrence (BCR) PCa.Subsequently, signature was established based on these genes.Kaplan-Meier survival estimates, receiver operating...
OBJECTIVES: In men, human prostate cancer (PCa) has become the second most common cancer. miRNAs are short non-coding RNAs that can inhibit target gene mRNAs. Studies have showed alternation of expression in is relevant to pathogenesis tumor. present study, we aimed investigate functions miR-214-5p PCa. MATERIALS AND METHODS: 10 paired tumor tissues and homologous para-tumor were recruited, levels CRMP5 respectively determined by qRT-PCR assay. Luciferase activity analysis was performed...
Introduction:Poor prognosis of gastric cancer (GC) has partly been a result late diagnosis due to nonspecific symptoms in the early stages.The overall survival rate patients with GC is quite low.Here, we presented functional role and potential mechanism long noncoding RNA STXBP5-AS1 GC. Materials methods: CCK-8, scratch wound healing Transwell assays were conducted analyze proliferation, migration, invasion SGC7901 MKN45 cells.Real-time polymerase chain reaction (qPCR) Western blot performed...
Numerous studies have shown drug resistance of gastric cancer cells could be modulated by abnormal expression microRNAs. Cisplatin (DDP) is one the most commonly used drugs for chemotherapy cancer. In this study, potential function miR-125b on DDP in was investigated. Sixteen miRNAs significantly differential expressed tumor tissues and adjacent were characterized their corresponding putative target genes also screened. MiR-125b selected as our focus its evident down-regulated among...
Long noncoding RNAs (lncRNAs) are known to be key regulators of numerous biological processes, and substantial evidence supports that abnormal lncRNA expression plays a significant role in tumorigenesis tumor progression. However, the mechanism by which lncRNAs function thyroid carcinoma still unclear. To investigate papillary (PTC), we analyzed data The Cancer Genome Atlas RNA-Seq database. A comparison cancerous tissues normal revealed hundreds differentially expressed lncRNAs. Of 7589...
miR-125a restrains cell migration and invasion by targeting STAT3 in gastric cancer cells Liu Yang,1,* Shuguang Zhang,2,* Kai Guo,3,* Hu Huang,4,* Shuai Qi,5 Jie Yao,6 Zhihong Zhang7 1Department of Cancer Biotherapy Center, Hubei Hospital, Wuhan, 430079, China; 2Department Clinical Laboratory, Liaocheng People's Liaocheng, Shandong 252000, 3Department Gastroenterology, The 161th Hospital PLA, 430010, 4Department Oncology, 5Department Pharmacy, 6Department Urological Surgery, Zhongnan Wuhan...
Atherosclerosis is a lipid-driven chronic inflammatory disease in which lipid-laden macrophage foam cells lead to inflamed lesions arteries. Previous studies have proven that sulfotransferase 2B1b (SULT2B1b) has several roles the regulation of lipid metabolism and response. However, little known about functions SULT2B1b ox-LDL-induced inflammation macrophages. In this study, after treatment with either ox-LDL alone or combined transfection siRNAs targeting SULT2B1b, IL-6, TNF-α, NF-κB, IKKβ...
Acute myocardial infarction is the leading cause of death and disability worldwide. Reperfusion main treatment method. However, ischemia-reperfusion (I/R) injury aggravates tissue cell damage. In this study, we aim to find a strategy reduce I/R promote cardiac function recovery. The expression AK003290 was downregulated in both vitro vivo. Overexpression reduced area, oxidative stress, apoptosis, promoted observed sponge miR-539-3p. Moreover, miR-539-3p upregulated injury. reversed...
MiRNAs as tumor suppressor have been identified in variety of cancer, but the role miRNAs involve ARS (acute radiation syndrome) Tibet minipig are poorly understood. Here, order to study relationship between pattern and ARS, microarray chip technology was used for screening related small intestine. Not castrated male Tibetan were chose animal model (n = 54), exposed total body X-ray at 0, 2, 5, 8, 11, 14 Gy (n= 9/ group), The miRNA extracted hybridized chip. HIC cell proliferation evaluated...