A5103131602- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Pain Management and Treatment
- Spine and Intervertebral Disc Pathology
- Botulinum Toxin and Related Neurological Disorders
- Pain Management and Opioid Use
- Anesthesia and Pain Management
- Shoulder Injury and Treatment
- Pain Management and Placebo Effect
- Transcranial Magnetic Stimulation Studies
- Myofascial pain diagnosis and treatment
- Pediatric Pain Management Techniques
- Muscle activation and electromyography studies
- Nerve injury and regeneration
- Cancer Treatment and Pharmacology
- Motor Control and Adaptation
- Zebrafish Biomedical Research Applications
- EEG and Brain-Computer Interfaces
- Opioid Use Disorder Treatment
- Pregnancy-related medical research
- Spinal Cord Injury Research
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Nerve Injury and Rehabilitation
Cleveland Clinic
2016-2025
The Neurological Institute
2023-2024
Cleveland Clinic Lerner College of Medicine
2009-2023
Lanzhou University
2015-2023
First Hospital of Lanzhou University
2015-2023
Pain Management Institute
2012-2022
Cerner (United States)
2022
Chinese People's Liberation Army
2020
Stanford University
2019
Novem (Netherlands)
2019
Abstract Appropriate patient selection and minimizing complications are critical for successful spinal cord stimulation (SCS) therapy in managing intractable pain. We thus reviewed electronic medical records of 707 consecutive cases patients who received SCS the Cleveland Clinic from 2000 to 2005 with an emphasis on indications complications. was used treat complex regional pain syndrome (CRPS) (345 cases), failed back surgery (235 peripheral vascular disease (20 visceral chest, abdomen,...
We have investigated sacral spinal cord lesions in rats with the goal of developing a rat model muscular spasticity that is minimally disruptive, not interfering bladder, bowel, or hindlimb locomotor function. Spinal transections were made at S2 level and, thus, only affected tail musculature. After transection, muscles inactive for 2 weeks. Following this initial period, hypertonia, hyperreflexia, and clonus developed tail, grew more pronounced time. These changes assessed awake rat, since...
We tested the hypothesis that neural networks for walking in mudpuppy can be divided into a flexor and an extensor center, each of which contains collections interneurons localized vicinity their motoneuron pools. Combining battery techniques, we identified elbow center its pool C2 segment C3 segment. Rhythmic flexion or extension limb isolation could induced by continuous trains current pulses segments, respectively. Independent activation also occur after application glutamate receptor...
Although the activation of cannabinoid receptor-1 (CB1) receptors by cannabinoids is known to inhibit neuronal hyperexcitability and reduce excitotoxic cell death, mechanistic links between these two actions remain elusive. We tested hypothesis that CB1 inhibits <i>N</i>-methyl-d-aspartic acid (NMDA)-mediated calcium influx death via inositol triphosphate (IP<sub>3</sub>) signaling pathway in both primary dorsal root ganglia neurons a cultured line (F-11 cells). These cells were pretreated...
Objectives: Sacroiliac joint pain is a common cause of low back (LBP). Cooled radiofrequency ablation (c-RFA) the lateral branches was recently introduced with hypothesis that it creates larger lesions to overcome anatomic variability and achieve better outcomes as compared traditional approach (t-RFA). The objective this comparative study determine if c-RFA superior over t-RFA in providing longer relief. Methods: Data on 88 patients were retrospectively collected between January 2006 June...
The plasmacytoma variant translocation 1 gene (PVT1) is a large non-coding locus at adjacent of c-Myc, and long RNA PVT1 now recognized as cancerous co-amplified with c-Myc in various cancers. But the expression functional role colorectal cancer are still unelucidated. In addition, all reported RNAs so far discovered either cells or tissues, but no research about detection extracellular vesicles has been yet. present study, we firstly investigated specimens its correlation other related...
Objective.Neuropathic pain is common and often difficult to treat because it generally does not respond well the currently available medications or nerve blocks. Recent studies in both humans animals have suggested that exercise may induce a transient analgesia reduce acute normal healthy individuals. We examined whether swim therapy could alleviate neuropathic rats.
We aim to determine the effects of botulinum toxin type A (BTX-A) on thresholds pain and expression transient receptor potential vanilloid 1 (TRPV1) in dorsal root ganglion (DRG) rats with neuropathic induced by selective ventral transection (VRT).Neuropathic was lumbar 5 male Sprague-Dawley rats. BTX-A or saline administered plantar surface subcutaneous injection. SB366791 (an inhibitor TRPV1) intraperitoneally. Behavioral tests were conducted preoperatively at predefined postoperative...
We aim to determine the effects of Botulinum toxin type A (BTX-A) on neuropathic pain behavior and expression P2X(3) receptor in dorsal root ganglion (DRG) rats with induced by L5 ventral transection (L5 VRT).Neuropathic was VRT male Sprague-Dawley rats. Either saline or BTX-A administered plantar surface. Behavioral tests were conducted preoperatively at predefined postoperative days. The receptors DRG neurons detected immunoreactivity days 3, 7, 14, 21.The number positive ipsilateral...
Kratom is an herb indigenous to Southeast Asia with psychoactive opioid compounds, often used as a treatment for chronic pain or opiate withdrawal symptoms. It legally and readily available via Internet sales has been identified emerging drug of abuse in the United States. use associated psychosis, seizures, even death. At lower doses, kratom acts stimulant, while at higher it produces analgesia euphoria. Here, we describe successful management overdose young man negative toxicology screens.
To determine the correlation between magnetic resonance imaging (MRI) pathology and response to diagnostic facet medial branch block (MBB) L5 dorsal ramus radiofrequency (RF) denervation of lumbar joints.The medical records 127 consecutive patients who underwent MBB for suspected zygapophysial joint pain were reviewed. The spine MRI these was systematically graded by 2 musculoskeletal radiologists loss disc height, spinal stenosis, degeneration, other forms pathology.Patients with central or...
Abstract More than 240 million opioid prescriptions are dispensed annually to treat pain in the US. The use of opioids is commonly associated with tolerance (OT) and opioid-induced hyperalgesia (OIH), which limit efficacy compromise safety. dearth effective way prevent or OT OIH a major medical challenge. We hypothesized that mesenchymal stem cells (MSCs) attenuate rats mice based on understanding MSCs possess remarkable anti-inflammatory properties both chronic neuroinflammation spinal...