A5100352427- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Head and Neck Cancer Studies
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Enzyme Catalysis and Immobilization
- Glycosylation and Glycoproteins Research
- Microbial Metabolic Engineering and Bioproduction
- DNA Repair Mechanisms
- Autophagy in Disease and Therapy
- Nerve injury and regeneration
- Epigenetics and DNA Methylation
- Meteorological Phenomena and Simulations
- Erythrocyte Function and Pathophysiology
- Bioinformatics and Genomic Networks
- Climate variability and models
- Advanced Proteomics Techniques and Applications
- Precipitation Measurement and Analysis
- Advanced biosensing and bioanalysis techniques
- Glaucoma and retinal disorders
- Amyotrophic Lateral Sclerosis Research
- Cell death mechanisms and regulation
Second Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Stanford University
2023-2025
University of Chinese Academy of Sciences
2019-2024
Shanghai Institute of Materia Medica
2019-2024
Chinese Academy of Sciences
2006-2024
Jining First People's Hospital
2024
Sichuan University
2024
Guangzhou Metro Group (China)
2024
Guangzhou Metro Design & Research Institute
2024
Solid tumors exhibit heterogeneous microenvironments, often characterized by limiting concentrations of oxygen (O2), glucose, and other nutrients. How oncogenic mutations alter stress response pathways, metabolism, cell survival in the face these challenges is incompletely understood. Here we report that constitutive mammalian target rapamycin complex 1 (mTORC1) activity renders hypoxic cells dependent on exogenous desaturated lipids, as levels de novo synthesized unsaturated fatty acids are...
Gee-Up, NEDD8 Diverse bacterial pathogens, such as Burkholderia pseudomallei and enteropathogenic Escherichia coli (EPEC), inject effector proteins into eukaryotic host cells to subvert cell biology. Cui et al. (p. 1215 ; published online 5 August) show that certain promoted the glutamine deamidation of ubiquitin ubiquitin-related protein, NEDD8. The modification inhibited formation polyubiquitin chains while, unexpectedly, same chemical alteration on interfered with cycle, offering insights...
The strength and duration of NF-κB signaling are tightly controlled by multiple negative feedback mechanisms. However, in cancer cells, these loops overridden through unclear mechanisms to sustain oncogenic activation signaling. Previously, we demonstrated that overexpression miR-30e* directly represses IκBα expression leads hyperactivation NF-κB. Here, report miR-182 was overexpressed a different set gliomas with relatively lower suppressed cylindromatosis (CYLD), an regulator. This...
[1] The severe drought that emerged in summer 2009 and persisted the subsequent fall winter southwest China caused a significant shortage of drinking drainage water. Precipitation during is much less than normal, meteorological extent exceeds climatic mean almost all days period. warmer-than-normal surface temperature facilitates hydrological agricultural through enhancing evaporation. less-than-normal water vapor atmosphere air both contribute to lower-than-normal relative humidity thus...
Significance Degeneration of demyelinated axons is a major cause permanent neurological disability in primary diseases myelin. In addition to myelin loss, dysfunction axonal mitochondria may be an essential requisite for degeneration axons. Here we describe significant increase mitochondrial volume following demyelination CNS A deficiency tethering the cytoskeleton prevented this and increased degeneration, which was rescued by pharmacological inhibition nerve transmission along axon. These...
Gastric cancer (GC) is one of the most common malignancies in Asian areas. PIEZO1 has been implied to regulate epithelial homeostasis play an important role physiological processes. It also related tumor initiation and progression. However, not yet explored GC. The expression GC cell lines primary samples was determined by qRT-PCR Western blot. clinical correlation evaluated immunohistochemistry on tissue microarray. oncogenic demonstrated gastric tumorigenesis through a series functional...
Abstract Crop diseases threaten food security and sustainable agriculture. Consumption of crops containing nonessential toxic metals leads to health risks for humans. Therefore, cultivation disease‐resistant metal‐safe is a double‐gain strategy that can contribute security. Here, we show rice heavy‐metal transporter OsNRAMP1 plays an important role in plant immunity by modulating metal ion reactive oxygen species (ROS) homoeostasis. expression was induced after pathogenic bacteria fungi...
Abstract Purpose: In this multicenter phase 3 trial, the efficacy and safety of 60 Gy 50 doses delivered with modern radiotherapy technology for definitive concurrent chemoradiotherapy (CCRT) in patients inoperable esophageal squamous cell carcinoma (ESCC) were evaluated. Patients Methods: pathologically confirmed stage IIA‒IVA ESCC randomized 1:1 to receive conventional fractionated or tumor regional lymph nodes. Concurrent weekly chemotherapy (docetaxel 25 mg/m2; cisplatin mg/m2) two...
Objectives:To assess the association between Rosai-Dorfman disease (RDD) and IgG4-related (IgG4-RD).
Physiological adaptation to proteotoxic stress in the endoplasmic reticulum (ER) requires retrotranslocation of misfolded proteins into cytoplasm for ubiquitination and elimination by ER-associated degradation (ERAD). A surprising paradox emerging from recent studies is that ubiquitin ligases (E3s) deubiquitinases (DUBs), enzymes with opposing activities, can both promote ERAD. Here we demonstrate ERAD E3 gp78 ubiquitinate not only substrates, but also machinery protein Ubl4A, a key...
Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motor neurons. Astrocytes from diverse ALS models induce neuron death in co-culture. Enhancing NAD+ availability, or increasing the expression NAD+-dependent deacylases SIRT3 and SIRT6, abrogates their neurotoxicity cell culture models. To determine effect availability mouse we used two strategies, ablation a NAD+-consuming enzyme (CD38) supplementation with bioavailable precursor (nicotinamide riboside, NR)....
Aberrant hyperactivation of cyclins results in carcinogenesis and therapy resistance cancers. Direct degradation the specific cyclin or cyclin-dependent kinase (CDK)-cyclin complex by small-molecule degraders remains a great challenge. Here, we applied first application hydrophobic tagging to induce CDK9-cyclin T1 heterodimer, which is required keep productive transcription oncogenes LL-K9-3 was identified as potent degrader T1. Quantitative time-resolved proteome profiling exhibited induced...
Sialic acid isomers attached in either α2,3 or α2,6 linkage to glycan termini confer distinct chemical, biological, and pathological properties, but they cannot be distinguished by mass differences traditional spectrometry experiments. Multiple derivatization strategies have been developed stabilize facilitate the analysis of sialic their glycoconjugate carriers high-performance liquid chromatography, capillary electrophoresis, workflows. Herein, a set novel schemes are described that result...
Optic neuropathy is a group of optic nerve (ON) diseases with progressive degeneration ON and retinal ganglion cells (RGCs). The lack neuroprotective treatments central challenge for this leading cause irreversible blindness. SARM1 (sterile α TIR motif-containing protein 1) has intrinsic nicotinamide adenine dinucleotide (NAD+) hydrolase activity that causes axon by degrading axonal NAD+ significantly after activation injury. deletion in many, but not all, neurodegenerative disease models....