A5068044479- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Cardiac Valve Diseases and Treatments
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Nitric Oxide and Endothelin Effects
- Heart Failure Treatment and Management
- Non-Invasive Vital Sign Monitoring
- Infective Endocarditis Diagnosis and Management
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiovascular Health and Disease Prevention
- Eicosanoids and Hypertension Pharmacology
- Aortic Disease and Treatment Approaches
- Anesthesia and Sedative Agents
- Venous Thromboembolism Diagnosis and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Renal function and acid-base balance
Université de Lille
2012-2025
Institut Pasteur de Lille
2016-2025
Centre Hospitalier Universitaire de Lille
2012-2024
Inserm
2016-2024
Lille’s Cardiology Hospital
2000-2018
Hôpital Claude Huriez
2000-2017
European Genomic Institute for Diabetes
2016-2017
Foundation of Cardiac Surgery Development
2016
Centre Hospitalier Universitaire de La Réunion
2015
Université Lille Nord de France
2010-2011
Abstract Introduction Central venous oxygen saturation (ScvO 2 ) is a useful therapeutic target in septic shock and high-risk surgery. We tested the hypothesis that central venous-to-arterial carbon dioxide difference (P(cv-a)CO ), global index of tissue perfusion, could be used as complementary tool to ScvO for goal-directed fluid therapy (GDT) identify persistent low flow after optimization preload has been achieved by loading during Methods This secondary analysis results obtained study...
<h3>Importance</h3> Low cardiac output syndrome after surgery is associated with high morbidity and mortality in patients impaired left ventricular function. <h3>Objective</h3> To assess the ability of preoperative levosimendan to prevent postoperative low syndrome. <h3>Design, Setting, Participants</h3> Randomized, double-blind, placebo-controlled trial conducted 13 French surgical centers. Patients a ejection fraction less than or equal 40% scheduled for isolated combined coronary artery...
Background: No randomized study powered to compare balloon expandable (BE) with self expanding (SE) transcatheter heart valves (THVs) on individual end points after aortic valve replacement has been conducted date. Methods: From January 2013 December 2015, the FRANCE-TAVI nationwide registry (Registry of Aortic Valve Bioprostheses Established by Catheter) included 12 141 patients undergoing BE-THV (Edwards, n=8038) or SE-THV (Medtronic, n=4103) for treatment native stenosis. Long term...
Postprocedural aortic regurgitation occurs in 10 to 20% of patients undergoing transcatheter aortic-valve replacement (TAVR) for stenosis. We hypothesized that assessment defects high-molecular-weight (HMW) multimers von Willebrand factor or point-of-care hemostasis could be used monitor during TAVR.We enrolled 183 TAVR. Patients with after the initial implantation, as identified by means transesophageal echocardiography, underwent additional balloon dilation correct regurgitation. HMW and...
A low dose (0.5 mg/kg) of lipopolysaccharide (LPS), administered 72 hours before 60-minute middle cerebral artery occlusion, induced a delayed neuroprotection proven by the significant decrease (–35%) brain infarct volume in comparison with control, whereas volumes remained unchanged rats treated 12, 24, or 168 ischemia. This neuroprotective effect LPS was only doses (0.25 to 1 mg/kg), this disappeared higher (2 mg/kg). The cortical part infarcted zone, not subcortical part. beneficial on...
Ischemia-reperfusion injury induces oxidant stress, and the burst of reactive oxygen species (ROS) production after reperfusion ischemic myocardium is sufficient to induce cell death. Mitochondrial may begin during ischemia prior because reducing equivalents accumulate promote superoxide production. We utilized a ratiometric redox-sensitive protein sensor (heat shock 33 fluorescence resonance energy transfer (HSP-FRET)) assess stress in cardiomyocytes simulated ischemia. HSP-FRET consists...
Abstract Introduction The purpose of this study was to evaluate the clinical relevance high values central venous-to-arterial carbon dioxide difference (PCO 2 gap) in high-risk surgical patients admitted a postoperative ICU. We hypothesized that PCO gap could serve as useful tool identify still requiring hemodynamic optimization at ICU admission. Methods One hundred and fifteen were included prospective single-center observational during 1-year period. High-risk inclusion criteria adapted...
Preoperative oral gabapentin has been shown to reduce postoperative pain. However, the effects of as an adjunct regional anesthesia is unclear and its on chronic pain remains unknown. In patients undergoing thyroidectomy, we investigated early late (at 6 mo) preoperative superficial cervical plexus block (SCPB).Fifty consecutive consenting were randomized receive either 1200 mg (Group G) or placebo P) 2 h preoperatively. anxiety was assessed a numeric scale from 0 6. A SCPB performed after...
Abstract Introduction Adequate volume expansion (VE) in patients with evidence of hypoperfusion should be aimed not only at achieving an increase stroke (SV) and cardiac index (CI) but also improved tissue perfusion oxygenation. Our aim this study was to assess the dynamic changes muscle oxygen saturation (StO 2 ) during hypovolaemia response VE. Methods We conducted a prospective 42 fluid challenges undergoing major abdominal surgery hypovolaemia, defined as pulse pressure variation (PPV)...
Abstract Background The mortality rate for a patient with refractory cardiogenic shock on venoarterial (VA) extracorporeal membrane oxygenation (ECMO) remains high, and hyperoxia might worsen this prognosis. objective of the present study was to evaluate association between 28-day in setting. Methods We conducted retrospective bicenter two French academic centers. population comprised adult patients admitted shock. following arterial partial pressure oxygen (PaO 2 ) variables were recorded...
Abstract Objectives The Ross procedure allows replacement of a diseased aortic valve with living valvular substitute and provides normal life span. However, progressive autograft dilatation subsequent neo-aortic regurgitation leading to reoperations remain major drawbacks. Our objective was assess long-term outcomes our modified technique pulmonary reinforcement in Valsalva Dacron graft. Methods Data from all patients who underwent institution between 2003 2020 were reviewed retrospectively....
Cerebrovascular abnormalities, in endothelium and smooth muscle compartments, occur the course of cerebral ischemia–reperfusion as evidenced by impairment endothelium-dependent relaxation decrease potassium inward rectifier density occluded middle arteries (MCAs). The authors investigated whether a delayed vascular protection occurred model brain ischemic tolerance. A low dose lipopolysaccharide (0.3 mg/kg) administered 72 h before MCA occlusion induced significant infarct volume. In...