A5087920662- Autopsy Techniques and Outcomes
- Forensic Anthropology and Bioarchaeology Studies
- Paleopathology and ancient diseases
- Forensic Toxicology and Drug Analysis
- Restraint-Related Deaths
- Forensic and Genetic Research
- Injury Epidemiology and Prevention
- Machine Learning in Materials Science
- Pesticide Exposure and Toxicity
- Forensic Entomology and Diptera Studies
- Traumatic Ocular and Foreign Body Injuries
- Poisoning and overdose treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Molecular Biology Techniques and Applications
- Mitochondrial Function and Pathology
- Herpesvirus Infections and Treatments
- Dental Radiography and Imaging
- Alcohol Consumption and Health Effects
- Polyomavirus and related diseases
- Metabolomics and Mass Spectrometry Studies
- SARS-CoV-2 and COVID-19 Research
- Trauma and Emergency Care Studies
- COVID-19 diagnosis using AI
- Nitric Oxide and Endothelin Effects
- Healthcare cost, quality, practices
Chiba University
2016-2025
The University of Tokyo
2015-2024
Center for Forensic Mental Health, Chiba University
2021
Tokyo Medical and Dental University
2019
University of Chicago
2003-2010
National Research Institute of Police Science
2008
Chiba Rosai Hospital
2004
Ischemia-reperfusion injury induces cell death, but the responsible mechanisms are not understood. This study examined mitochondrial depolarization and death during ischemia reperfusion. Contracting cardiomyocytes were subjected to 60-min followed by 3-h Mitochondrial membrane potential (ΔΨ m ) was assessed with tetramethylrhodamine methyl ester. During ischemia, ΔΨ decreased 24 ± 5.5% of baseline, no recovery evident Cell Sytox Green minimal averaged 66 7% after Cyclosporin A, an inhibitor...
Ischemia-reperfusion injury induces oxidant stress, and the burst of reactive oxygen species (ROS) production after reperfusion ischemic myocardium is sufficient to induce cell death. Mitochondrial may begin during ischemia prior because reducing equivalents accumulate promote superoxide production. We utilized a ratiometric redox-sensitive protein sensor (heat shock 33 fluorescence resonance energy transfer (HSP-FRET)) assess stress in cardiomyocytes simulated ischemia. HSP-FRET consists...
Closure of cranial sutures progresses with age; therefore, macroscopic assessment has been used as one method age estimation. Postmortem computed tomography (PMCT), which many forensic medical departments and institutes have begun to adopt, the potential simplify gathering information from for both surface cross-sectional evaluation. To examine feasibility estimation by multidetector images sagittal suture, PMCT findings 125 subjects known sex were retrospectively reviewed. The suture was...
Purpose: The advent of next-generation sequencing technologies has enabled the identification several activating mutations Erb-B2 receptor tyrosine kinase 2 (ERBB2) among various cancers. However, significance infrequent not been fully investigated. Herein, we comprehensively assessed functional ERBB2 in a high-throughput manner.Experimental Design: We evaluated transforming activities and drug sensitivities 55 nonsynonymous using mixed-all-nominated-in-one (MANO) method.Results: G776V,...
High viral titers of infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been detected in human corpses long after death. However, little is known about the kinetics SARS-CoV-2 corpses. In this case series study, we investigated postmortem by collecting nasopharyngeal swab samples at multiple time points from six SARS-CoV-2-infected patients their RNA was quantitative reverse transcription-polymerase chain reaction collected all deceased patients. A culture showed...
Pulp cavity size is known to decrease with age and can therefore serve as an indicator for estimation. Here, we evaluated whether reconstructed images of multidetector-row computed tomography (MDCT) acquired before forensic autopsy are useful estimating at death. Images 136 mandibular first premolars obtained from bodies death were analyzed, the volume regions corresponding pulp that whole tooth determined using a voxel counting function. The was clearly distinguishable dental hard tissue on...
Abstract: Postmortem computed tomography (CT) images can show internal findings related to the cause of death, and it be a useful method for forensic diagnosis. In this study, we scanned ready‐made box by helical CT on 2‐mm slices in mobile scanner measured each side assess whether reconstructed are superimposition. The mean difference between actual measurements three‐dimensional (3D) (3D‐CT images) is 0.9 mm; regarded as having no effect reconstruction superimposition method. Furthermore,...
Abstract We consecutively observed lipid peroxidation and cell membrane damage under the condition of hypoxia‐reoxygenation (H/R) in cells analyzed their mechanisms by using electron transport inhibitors an antioxidant. In H/R experiments, were during hypoxia phase. reoxygenation phase, stopped, while did not. An antioxidant, n‐acetylcystein (NAC), potassium cyanide (KCN) inhibited damage, rotenone not inhibit either them. Although antimycin A peroxidation, it phase but These results...