A5102843574- Molecular Biology Techniques and Applications
- Forensic and Genetic Research
- Forensic Anthropology and Bioarchaeology Studies
- Pesticide Exposure and Toxicity
- Polyomavirus and related diseases
- Cholinesterase and Neurodegenerative Diseases
- Paleopathology and ancient diseases
- Identification and Quantification in Food
- Herpesvirus Infections and Treatments
- Parvovirus B19 Infection Studies
- Environmental Toxicology and Ecotoxicology
- Environmental DNA in Biodiversity Studies
- Full-Duplex Wireless Communications
- Genomics and Phylogenetic Studies
- Urological Disorders and Treatments
- Computational Drug Discovery Methods
- Blood groups and transfusion
- Virus-based gene therapy research
- Poxvirus research and outbreaks
- Metabolomics and Mass Spectrometry Studies
- Forensic Entomology and Diptera Studies
- Nitric Oxide and Endothelin Effects
- Archaeology and ancient environmental studies
- Forensic Toxicology and Drug Analysis
- Blood properties and coagulation
Tokyo Medical and Dental University
2015-2025
Institute of Science Tokyo
2025
The University of Tokyo
1998-2019
National Research Institute of Police Science
2007-2016
Hokkaido Prefectual Police
2011
Kyoto Prefectural University of Medicine
2010
Chiba University
2008
Analyzing forensically relevant body fluids contributes to proving criminal acts, and saliva is often left on the scene, especially in sexual assault cases.
Diphenhydramine is widely used as an over-the-counter antihistamine. However, the specific human cytochrome P450 (P450) isozymes that mediate metabolism of diphenhydramine in range clinically relevant concentrations (0.14–0.77 μM) remain unclear. Therefore, involved <i>N</i>-demethylation, a main metabolic pathway diphenhydramine, were identified by liquid chromatography-mass spectrometry method developed our laboratory. Among 14 recombinant isozymes, CYP2D6 showed highest activity...
BK polyomavirus (BKV) is highly prevalent in the human population, infecting children without obvious symptoms and persisting kidney a latent state. In immunosuppressed patients, BKV reactivated excreted urine. isolates worldwide are classified into four serologically distinct subtypes, I–IV, with subtype I being most frequently detected. Furthermore, subdivided subgroups based on genomic variations. this study, distribution patterns of subtypes were compared among patient populations...
Abstract: In this study, the specificity, sensitivity, and operability of RSID™‐Urine, a new immunochromatographic test for urine identification, was evaluated compared with ELISA detection Tamm‐Horsfall protein (THP). Urine successfully identified among other body fluids using RSID™‐Urine THP. The limit equated to 0.5 μL urine; although sensitivity may be lower than that THP, it is thought sufficient application casework samples. However, results from must interpreted caution when sample...
In this study, Tamm-Horsfall protein (THP), a major component of urinary protein, and uroplakin III (UPIII), transmembrane widely regarded as urothelium-specific marker, were evaluated for forensic identification urine by ELISA and/or immunohistochemistry. THP was detected in urine, but not plasma, saliva, semen, vaginal fluid, or sweat the simple method developed study. addition, most aged stains showed positive results. The specificity confirmed gene expression analysis. Therefore,...
The detection of semen in forensic investigation is considered important evidence sexual assault. In this study, we report the development a real-time polymerase chain reaction-based method for identifying that can simply and rapidly analyze semen-specific unmethylated region DACT1 gene. Using two fluorescent probes designed methylated or status, could perform quantitative analysis methylation status region. Furthermore, was used to various body fluid samples, including 29-year-old blood...