A5002149141- Pesticide Exposure and Toxicity
- Mass Spectrometry Techniques and Applications
- Insect and Pesticide Research
- Advanced Chemical Sensor Technologies
- Bacillus and Francisella bacterial research
- Pesticide Residue Analysis and Safety
- Toxin Mechanisms and Immunotoxins
- Analytical Chemistry and Chromatography
- Pesticide and Herbicide Environmental Studies
- Cassava research and cyanide
- Transgenic Plants and Applications
- Analytical chemistry methods development
- Cholinesterase and Neurodegenerative Diseases
- Electrochemical sensors and biosensors
- Paraquat toxicity studies and treatments
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Glycosylation and Glycoproteins Research
- Cannabis and Cannabinoid Research
- Forensic Toxicology and Drug Analysis
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
- Computational Drug Discovery Methods
- TiO2 Photocatalysis and Solar Cells
- Heme Oxygenase-1 and Carbon Monoxide
SPring-8
2015-2024
National Research Institute of Police Science
2013-2023
National Institute of Advanced Industrial Science and Technology
2009-2023
Chiba University
2009-2010
University of Shizuoka
2010
Nagoya University
2009
Gifu Pharmaceutical University
2009
Tokyo Metropolitan Police Department
2005
Kitasato Institute Hospital
2004
Meiji University
2001
Aminium radicals have been proposed as intermediates in amine N-dealkylations and N-oxygenations catalyzed by cytochrome P450 (P450) some other enzymes. P450s can form N-oxides hydroxylamines but these are not favored whenever N-dealkylation is possible. However, if a paradigm involving 1-electron oxidation valid, then finite level of partitioning aminium between N-oxygenation might be expected all cases. Methods were developed for the selective sensitive measurement N,N-dialkylaniline using...
Abstract The threat of biological and chemical terror acts remains a growing worldwide concern. There is therefore need to develop appropriate technology for the detection warfare agents, with early identification intended use by first responders. Here, we disclose developed autonomous air sampling system evaluation presence agents that can be harmful population. current device utilizes designed mist generator-assisted collection (338 l min −1 ) biosensing chip technologies, such as...
A cytochrome P-450 was isolated from a fungus, Fusarium oxysporum, which grew on medium containing soybean oil as sole carbon source. It found heme protein that possess lipoxygenase activity, and seemed to exist in the soluble fraction of cell-free extracts. The revealed multiplicity could be separated into least 3 fractions (A, B, C). Two them, termed P-450A -B, were highly purified. complex ferrous with monoxide showed Soret peak at 447 nm. properties cytochromes (P-450A -b) closely...
We have detected biological toxins using localized surface plasmon resonance (LSPR) and synthetic glycosyl ceramides (β-lactoside, globosyl trisaccharide (Gb3), or GM1 pentasaccharide) attached to gold (Au) nanoparticles. The particle diameters ranged from 5–100 nm. detection sensitivity for three (ricin, Shiga toxin, cholera toxin) was found depend not only on the glycoside but also diameter of Au For ricin, 20-nm β-lactoside-coated nanoparticle exhibited highest LSPR response, whereas...
The adsorption and photocatalytic degradation of nerve agent, isopropyl methylphosphonofluoridate, Sarin (GB) on powdery TiO2 film has been investigated using attenuated total reflection-infrared Fourier transform spectroscopy (ATR-FTIR) in ambient atmosphere. Producing innocuous methylphosphonic acid as a consequence GB at the surface indicates that is effective to hydrolyze GB. adsorbed IMPA were quickly decomposed by photocatalysis give isopropanol, acetone, formate, acid, finally...
Abstract A number of synthetic cannabinoids have been appearing in the recreational drug market for more than a decade. Recent additions are so‐called semi‐synthetic cannabinoids, and they structurally closely resemble main psychoactive component cannabis, Δ 9 ‐tetrahydrocannabinol. Knowledge new (semi‐)synthetic is essential to help identify them authentic forensic case samples. Therefore, aim study was examine two commercially available electronic cigarette liquid products claiming contain...
Ricin is a glycosylated proteinous toxin that registered as toxic substance by Chemical Weapons convention. Current detection methods can result in false negatives and/or positives, and their criteria are not based on the identification of protein amino acid sequences. In this study, lactose-immobilized monolithic silica extraction followed tryptic digestion liquid chromatography/mass spectrometry (LC/MS) was developed method for rapid accurate determination ricin. Lactose, which immobilized...
A gas-cylinder-free plasma desorption/ionization system was developed to realize a mobile on-site analytical device for detection of chemical warfare agents (CWAs). In this system, the source directly connected inlet mass spectrometer. The can be generated with ambient air, which is drawn into discharge region by negative pressure in High-power density pulsed 100 kW could using microhollow cathode and laboratory-built high-intensity power supply (pulse width: 10-20 μs; repetition frequency:...
A new class of synthetic cannabinoids termed OXIZIDs has recently emerged on the recreational drug market. In order to continue detection drugs in biological specimens, identification metabolites is essential. The aim this study was elucidate BZO-4en-POXIZID produced human liver microsomes (HLMs) and hepatocyte incubations compare results with closely related analogs using same experimental setup. Each incubated for 1 h HLM also hepatocytes up 3 h. Subsequently, incubates were analyzed by...