A5040396096- Forensic Toxicology and Drug Analysis
- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Psychedelics and Drug Studies
- Analytical chemistry methods development
- Cannabis and Cannabinoid Research
- Environmental Chemistry and Analysis
- Molecular Sensors and Ion Detection
- Neuroscience of respiration and sleep
- TiO2 Photocatalysis and Solar Cells
- Porphyrin and Phthalocyanine Chemistry
- Advanced Photocatalysis Techniques
- Electrochemical sensors and biosensors
- Cassava research and cyanide
- Crystallography and molecular interactions
- Luminescence and Fluorescent Materials
- Alcohol Consumption and Health Effects
- Neurotransmitter Receptor Influence on Behavior
- Sulfur Compounds in Biology
- Conducting polymers and applications
- Anesthesia and Sedative Agents
- Fluorine in Organic Chemistry
- Nicotinic Acetylcholine Receptors Study
- Polyoxometalates: Synthesis and Applications
- Intensive Care Unit Cognitive Disorders
Ishikawa Prefectural Police
2015-2025
Kanazawa University
2018-2024
Waseda University
2009-2010
Austral University of Chile
2009
École Polytechnique Fédérale de Lausanne
2008
Abstract A promising redox system, offering an alternative to the widely used iodide/triiodide couple, based on stable organic radical 2,2,6,6‐tetramethyl‐1‐piperidinyloxy (TEMPO) has been employed in dye‐sensitized solar cells. The photovoltaic performance of this new couple evaluated by employing nanocrystalline TiO 2 films with different thickness. Judicious selections a 5.0 μm photoanode made from mesoscopic particles and sensitizer high molar extinction coefficient yield overall...
Abstract A robust nitroxide radical, 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and its 4-subsituted derivatives (R-TEMPO) exhibit electrochemically reversible redox properties with tunable half-wave potentials (E1/2) based on the substituent effect. Dye-sensitized solar cells using R-TEMPO as mediators electron-withdrawing R groups showed significantly enhanced photovoltages compared those obtained iodides. The linearity between open-circuit voltage (Voc) E1/2 revealed that Voc was...
Abstract In forensic drug analysis, extractive pretreatment is required prior to instrumental analysis ensure successful detection of the target compounds. However, conventional extraction methods such as hydrophilic polymer‐based solid‐phase and liquid–liquid are unsuitable for an emerging class new psychoactive substances, namely, synthetic cathinones, because they exhibit a lack selectivity increased risk analyte decomposition during extraction. To address these issues, we describe highly...
Abstract Herbicide poisoning commonly involves both paraquat and diquat (DQ); DQ alone is less frequently reported, especially rare in Japan. We present a case of fatal after attempted suicide by ingesting dibromide, requiring intensive care including hemodialysis (HD). Toxicological profiles DQ, metabolites, bromide ion serum were investigated relative to the course treatment. Quantitative analyses carried out liquid chromatography/tandem mass spectrometry (LC-MS/MS) for its oxidative...
Abstract A number of synthetic cannabinoids have been appearing in the recreational drug market for more than a decade. Recent additions are so‐called semi‐synthetic cannabinoids, and they structurally closely resemble main psychoactive component cannabis, Δ 9 ‐tetrahydrocannabinol. Knowledge new (semi‐)synthetic is essential to help identify them authentic forensic case samples. Therefore, aim study was examine two commercially available electronic cigarette liquid products claiming contain...
Mass spectrometric differentiation of structural isomers is important for the analysis forensic samples. Presently, there no mass method differentiating halogen positional cannabimimetic compounds. We describe here a novel and practical one these compounds, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide (AB-FUBINACA (para)), its fluoro (ortho meta) in phenyl ring by electron ionization-triple quadrupole spectrometry. It was found that three differed...
Positional isomer differentiation is crucial for forensic analysis. The aim of this study was to differentiate AB-FUBINACA positional isomers using liquid chromatography (LC)-electrospray ionization (ESI)-linear ion trap mass spectrometry (LIT-MS) and LC-ESI-triple quadrupole (QqQ-MS).AB-FUBINACA, its two fluorine on the phenyl ring, three methyl in carboxamide side chain were analyzed by LC-ESI-LIT-MS LC-ESI-QqQ-MS.Four isomers, excluding 3-fluorobenzyl isomer, chromatographically separated...
Abstract A reliable method for structural analysis is crucial the forensic investigation of new psychoactive substances (NPSs). Towards this end, mass spectrometry one most efficient and facile methods identification NPSs. However, differentiation among 2‐, 3‐, 4‐fluoromethcathinones ( o ‐, m p ‐FMCs), which are ring‐fluorinated positional isomers part major class NPSs referred to as synthetic cathinones, remains a challenge. This mostly due their similar retention properties nearly...
Positional isomers o-, m-, and p-chloromethcathinones (CMCs) m- p-bromomethcathinones (BMCs) were effectively differentiated using gas chromatography (GC) energy-resolved mass spectrometry (ERMS) analyses. GC demonstrated that the free bases of CMC BMC simultaneously baseline-separated at a slow column heating rate (5 °C/min) conventional low-polar capillary column. ERMS showed trifluoroacetyl derivatives positional differed in spectral abundances both halophenyl halobenzoyl cations....
The standard theory regarding the interactions between polyelectrolytes and their counterions is based on long-range electrostatic interactions. However, aromatic may undergo short-range aromatic-aromatic with containing rings so that ion pairs be formed. charge of polymeric groups linear density play an important role behavior systems. Self-aggregation polymer environment can controlled.
We describe a unique UV-visible absorption spectral property of 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin (THPP) in the presence organophosphorus (OP) pesticides. Upon titrating each 16 among total 40 different OP pesticides, Soret band was significantly red-shifted, and very intense Q appeared. They were attributed to diprotonation THPP. A suitable solvent for this reaction determined be methanol. THPP would become potential sensor molecule used detect pesticides with high sensitivity...
We present herein a practical methodology for elucidating the o-, m-, or p-fluorine substitution pattern of indazole-type synthetic cannabinoids containing fluorobenzyl group at N-1 position and carbonyl C-3 via electron ionization-triple quadrupole mass spectrometry. synthesized, as model compounds cannabinoids, positional isomers: 1-[1-(2-, 3-, 4-fluorobenzyl)-1H-indazol-3-yl]ethanone (o-, p-FUBINAE). Mass spectral analyses showed that three isomers differed significantly in logarithmic...
Recently, biodegradable aminopolycarboxylic acid chelating agents have attracted attention as an alternative to environmentally persistent such ethylenediamine-N,N,N',N'-tetraacetic acid. However, the detection of requires complexation with metals or derivatization by esterification reagents, and their direct using currently available analytical methods still represents a challenge. Herein, we describe method for ethylenediamine-N,N'-disuccinic acid, 3-hydroxy-2,2'-iminodisuccinic...
We have developed an analytical method for the determination of hydrogen sulfide in whole blood by headspace-gas chromatography/mass spectrometry (HS-GC/MS) using Rt-Q-BOND column (a nonpolar porous layer open tubular incorporating 100% divinylbenzene). This system allows baseline-separation sulfide, cyanide, arsenide, and azide, as well alcohols organic solvents forensic interest. The sample preparation procedure, which only involves mixing specimen with acetone phosphoric acid, is simple...
Quick, easy, cheap, effective, rugged, and safe extraction strategies are becoming increasingly adopted in various analytical fields to determine drugs biological specimens. In the present study, we developed two fully automated quick, methods based on acetonitrile salting-out assisted liquid-liquid (method 1) followed by dispersive solid-phase 2) using a commercially available system. We applied these of 14 psychotropic (11 benzodiazepines carbamazepine, quetiapine, zolpidem) from whole...