A5031097328- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Sarcoma Diagnosis and Treatment
- Transplantation: Methods and Outcomes
- Neuroendocrine Tumor Research Advances
- Cancer and Skin Lesions
- Medical Imaging and Pathology Studies
- Lung Cancer Research Studies
- Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
- Neurofibromatosis and Schwannoma Cases
- Histiocytic Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Cancer Diagnosis and Treatment
- Cardiac Ischemia and Reperfusion
- Pancreatic and Hepatic Oncology Research
- Connexins and lens biology
- Soft tissue tumor case studies
- Nitric Oxide and Endothelin Effects
- Viral-associated cancers and disorders
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Heat shock proteins research
Tokai University
2001-2025
Kagoshima University
2010-2017
Kansai Rosai Hospital
2010
Japan Organization of Occupational Health and Safety
2005-2009
Yokohama Rosai Hospital
2009
The University of Tokyo
1999-2004
Yamaguchi University
2001
Osaka University
2001
Nara Medical University
2001
Wakayama Medical University
2001
Abstract —Ischemic preconditioning (IP) exerts cardioprotection through protein kinase C (PKC) activation, whereas myocardial ischemia enhances vascular endothelial growth factor (VEGF) mRNA expression. However, the IP effect or involvement of PKC on VEGF expression is unknown in infarction. We investigated whether gene and angiogenesis activation vivo infarction model. Sprague-Dawley rats were assigned into following 3 groups: sham group; group, which underwent cycles minutes 5 reperfusion...
Abstract —Although ischemic stress, including preconditioning (IP), activates p38 mitogen-activated protein kinase (MAPK), the relationship between MAPK activation and underlying cellular mechanisms of cardioprotection by IP is not verified in vivo. We examined effects selective inhibition on cardioprotective effect open-chest dogs. The coronary artery was occluded 4 times for 5 minutes, separated minutes reperfusion (IP) followed 90 occlusion 6 hours reperfusion. infused SB203580 into...
Pancreatic cancer is still a disease of high mortality despite availability diagnostic techniques. Mucins (MUC) play crucial roles in carcinogenesis and tumor invasion pancreatic neoplasms. MUC1 MUC4 are molecular weight transmembrane mucins. These overexpressed many carcinomas, expression these molecules risk factor associated with poor prognosis. We evaluated the methylation status promoter regions tissue samples from 169 patients various lesions by specific electrophoresis (MSE) method....
ABSTRACT Aspergillus tracheobronchitis is a form of invasive aspergillosis that primarily occurs in immunocompromised patients. We report case bronchitis an immunocompetent 55‐year‐old woman with mucus plug at the site localised bronchiectasis. The gradually enlarged over 9 years, when patient exhibited submissive haemoptysis. Bronchial artery embolization, followed by partial lung resection was performed. Pathological and mycological examinations led to diagnosis AT caused udagawae .
A panel of immunohistochemical (IHC) stains frequently used to subclassify non-small cell lung cancers (NSCLCs) includes napsin A, TTF-1, CK5/6, p40, and p63. The expression profiles these in neuroendocrine tumors have not been systematically evaluated.Sixty-eight resected pulmonary tumors, including 52 typical carcinoids (TCs), eight atypical (ACs), seven small carcinomas (SCLCs) one large carcinoma (LCNEC), were stained for p63, CK5/6. Tumors scored as positive (>1% tumor cells reactive)...
There is a paucity of data on the diagnostic efficacy liquid-based cytology (LBC) for pancreatic samples obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Using propensity score matching, we retrospectively analyzed additional value LBC compared to conventional Papanicolaou smear (CPS) solid lesions EUS-FNA.This cohort study included 126 matched patients who underwent initial EUS-FNA between January 2009 and August 2014. CPS was used until May 2012 (63 patients)....
This study presents an extremely rare case of constrictive bronchiolitis obliterans (BO) associated with Stevens-Johnson Syndrome (SJS) provides the morphological and immunohistochemical features using histopathological bronchial reconstruction technique. A 27-year-old female developed progressive dyspnea after SJS induced by taking amoxicillin at age 10. Finally, she died exacerbation type II respiratory failure 17 years from clinically diagnosed as having BO. Macroscopic whole lungs...
// Takuya Yoshimura 1 , Taiji Hamada 2 Hiroshi Hijioka Masakazu Souda Kazuhito Hatanaka Takako Yoshioka 3 Sohsuke Yamada Masato Tsutsui 4 Yoshihisa Umekita 5 Norifumi Nakamura Akihide Tanimoto Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School Medical Dental Sciences, Kagoshima, Japan Pathology, Children's Cancer Center, National Center for Child Health Development, Tokyo, Pharmacology, Faculty Medicine, the Ryukyus, Okinawa, Division Organ Tottori University,...
// Taiji Hamada 1 , Masakazu Souda Takuya Yoshimura 2 Shoko Sasaguri Kazuhito Hatanaka Takashi Tasaki Takako Yoshioka Yasuyo Ohi 3 Sohsuke Yamada 4 Masato Tsutsui 5 Yoshihisa Umekita 6 and Akihide Tanimoto Department of Molecular Cellular Pathology, Kagoshima University Graduate School Medical Dental Sciences, Kagoshima, Japan. Oral Maxillofacial Surgery, Sagara Hospital, Social Corporation Hakuaikai, Pathology Cell Biology, Medicine, Occupational Environmental Health, Kitakyushu,...
To establish treatments to improve the prognosis of cancer patients, it is necessary find new targets control metastasis. We found that expression FilaminC (FLNC), a member actin binding and cross-linking filamin protein family correlated with lymphatic invasion metastasis in esophageal squamous cell carcinoma (ESCC) by increasing motility through activation Rho GTPase.Immunohistochemistry analysis showed FLNC ESCC associated invasion, metastasis, prognosis. knockdown lines decreased...
Connexin 43 (Cx43), a primary component of gap junctions, contributes to intercellular electrochemical communication. Cx43 undergoes dephosphorylation in early ischemia. We examined whether is degraded association with during myocardial ischemia and ischemic preconditioning (IP) affects the degradation after rat coronary artery occlusion. Male Sprague-Dawley rats underwent occlusion for 1, 2, or 3 hours, 1 hour following treatment either calcineurin inhibitor (cyclosporine A), proteasome...
A 41-year-old man was diagnosed with a solitary fibrous tumor (SFT) of the pleura in posterior mediastinum. Despite two surgeries for excision, SFT recurred and progressed direct invasion chest wall bone metastases. He hospitalized because cerebral infarction presented recurrent severe hypoglycemia fourteen years later. High-molecular-weight (HMW) insulin-like growth factor II (IGF-II) identified serum using Western blotting immunohistochemistry. These findings suggested that cause...
Abstract Background Mucocele-like lesions (MLL) of the breast were originally described as benign composed multiple cysts lined by uniform flat to cuboidal epithelium with extravasated mucin, but subsequent reports coexistence columnar cell (CCL), atypical ductal hyperplasia (ADH) and carcinoma in situ (DCIS). Several have investigated whether core biopsy can diagnose MLL reliably; however, there is only one report a long-term follow-up after excision MLL. We here 15 surgically excised...
To clarify the morphological mechanisms of airway obliteration in bronchiolitis obliterans (BO) associated with various causes, we conducted a retrospective study 9 patients histological diagnosis BO. The characteristics were analyzed by histopathological bronchial reconstruction. BO was classified into two major morphologic subtypes: constrictive (CoB) and cellular/destructive (CDB). CoB is characterized concentric narrowing lumen due to submucosal fibrosis. In contrast, CDB intraluminal,...
Plasmablastic lymphoma (PBL) is a rare that characterized by diffuse proliferation of large neoplastic cells resembling B immunoblasts, but shows the immunophenotype plasma cells. PBL most commonly seen in oral cavity human immunodeficiency virus (HIV)-positive patients. Epstein-Barr (EBV) may be closely related pathogenesis PBL. We report case HIV-negative 75-year-old man without EBV infection. Histologic examination cecal tumor following right hemicolectomy and cytologic ascitic fluid were...
Interstitial lung diseases (ILDs) are common in patients with connective tissue (CTDs). Although the diagnosis of an underlying CTD ILD (CTD-ILD) affects both prognosis and treatment, it is sometimes difficult to distinguish CTD-ILD from chronic fibrosing interstitial pneumonia (CFIP). B cell–activating factor belonging tumour necrosis family (BAFF) plays a crucial role cell development, survival, antibody production. We examined serum levels BAFF, surfactant protein D (SP-D), Krebs von den...
Malignant melanoma (MM) tends to be spontaneously regressed, however, complete regression of primary cutaneous MM is an extremely rare phenomenon. Our aim aware that pathologists and/or dermatologists can readily misinterpret it as the other benign or malignant lesions. A gradually growing and verrucous hypopigmented macule had been noticed in right sole a 65-year-old Japanese male since 2 years before, turned solitary bluish black patch with surrounding depigmentation was recently decreased...