A5082757646- Asthma and respiratory diseases
- Antifungal resistance and susceptibility
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Respiratory Support and Mechanisms
- Lung Cancer Research Studies
- Pleural and Pulmonary Diseases
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Myasthenia Gravis and Thymoma
- Colorectal Cancer Treatments and Studies
- Olfactory and Sensory Function Studies
- Vascular Anomalies and Treatments
- Pediatric health and respiratory diseases
- Indoor Air Quality and Microbial Exposure
- Tracheal and airway disorders
- Fatty Acid Research and Health
- Medical Imaging and Pathology Studies
- Infectious Diseases and Mycology
- Allergic Rhinitis and Sensitization
- Cancer Immunotherapy and Biomarkers
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Tokai University
2016-2025
Nagano Municipal Hospital
2017
Keio University
2009-2014
Pulmonary Associates
2010
Allergic bronchopulmonary aspergillosis (ABPA) is an allergic pulmonary disease characterized by a hypersensitivity reaction to Aspergillus species colonizing the airways. The clinical characteristics of ABPA may differ depending on genetic and environmental background. We performed nationwide survey determine in Japan.In 2013, questionnaire physician-diagnosed ABPA/allergic mycosis was sent 903 medical centers specializing respiratory or diseases. Cases fulfilling following criteria were...
Despite standard treatment with systemic corticosteroids and/or antifungal triazoles, a substantial proportion of patients allergic bronchopulmonary aspergillosis (ABPA) experience frequent relapses and require long-term despite unfavorable adverse effects. We investigated the efficacy safety anti-interleukin (IL)-5/IL-5 receptor α chain (Rα) monoclonal antibodies (mAbs) in ABPA complicated by asthma. cases treated anti-IL-5/IL-5Rα mAbs were collected from 132 medical institutes 2018...
Bone mineral density (BMD) alone does not reliably predict osteoporotic fractures. The Fracture Risk Assessment Tool (FRAX) was developed to estimate the risk of fracture in general population. This study designed identify predictors osteoporosis and vertebral fractures patients presenting with chronic obstructive pulmonary disease (COPD). We studied 85 (mean age = 75 years; 92% men) moderate very severe COPD. Osteoporosis were diagnosed dual energy X-ray absorptiometric scan X-rays,...
Exhaled volatile organic compounds (VOC) are being considered as biomarkers for various lungs diseases, including cancer. However, the accurate measurement of extremely low concentrations VOC in expired air is technically challenging. We evaluated clinical contribution exhaled measured with a new, double cold-trap method diagnosis lung cancer.Breath samples were collected from 116 patients histologically confirmed cancer and 37 healthy volunteers (controls) after inspiration purified air,...
Abstract Background Allergic bronchopulmonary aspergillosis (ABPA) develops in the presence or absence of asthma, either atopic nonatopic. We have tried to explore essential components pathogenesis disease, which are consistent and variable according type asthma. Methods Non‐cystic fibrosis ABPA cases satisfying Asano's criteria were extracted from a prospective registry related diseases Japan between 2013 2023. According preceding was classified into three groups: sans asthma (no asthma),...
ABSTRACT Aspergillus tracheobronchitis is a form of invasive aspergillosis that primarily occurs in immunocompromised patients. We report case bronchitis an immunocompetent 55‐year‐old woman with mucus plug at the site localised bronchiectasis. The gradually enlarged over 9 years, when patient exhibited submissive haemoptysis. Bronchial artery embolization, followed by partial lung resection was performed. Pathological and mycological examinations led to diagnosis AT caused udagawae .
Allergic bronchopulmonary mycosis, characterized by excessive mucus secretion, airflow limitation, bronchiectasis, and peripheral blood eosinophilia, is predominantly caused a fungal pathogen, Aspergillus fumigatus. Using DNA microarray analysis of NCI-H292 cells, human bronchial epithelial cell line, stimulated with extracts from A. fumigatus, Alternaria alternata, or Penicillium notatum, we identified mucin-related MUC5AC as one the genes, expression which was selectively induced...
Abstract Background Allergic bronchopulmonary mycosis (ABPM) is an allergic disease caused by type I and III hypersensitivity to environmental fungi. Schizophyllum commune , a basidiomycete fungus, one of the most common fungi that causes non‐ Aspergillus ABPM. Objective Herein, we attempted clarify clinical characteristics ABPM S. (ABPM‐Sc) compared with those aspergillosis (ABPA). Methods Patients ABPM‐Sc or ABPA were recruited from nationwide survey in Japan, multicenter cohort, fungal...
Abstract Background High‐attenuation mucus (HAM) is a specific manifestation of allergic bronchopulmonary mycosis (ABPM) on chest computed tomography (CT). Objectives To compare the diagnostic accuracy two definitions HAM and to clarify clinical radiographic characteristics HAM‐positive HAM‐negative ABPM. Methods CT images at diagnosis ABPM using Asano's criteria were retrospectively analysed. In Study #1, data obtained same apparatus in single institute analysed determine agreement between...
<b><i>Background:</i></b> Allergic bronchopulmonary aspergillosis (ABPA) develops in the presence of predisposing conditions such as asthma and cystic fibrosis. Even ABPA accompanied by is often complicated chronic <i>Pseudomonas aeruginosa</i> or nontuberculous mycobacterial infection lower respiratory tract, rendering treatment with corticosteroids difficult. There have been several reports on effectiveness omalizumab, an anti-IgE antibody, patients...
Background. Allergic fungal airway diseases, such as asthma and allergic bronchopulmonary mycosis (ABPM), are often difficult to manage with medical treatment alone; therefore, environmental exposure should be accurately evaluated minimized. In the present study, we established a method evaluate eliminate contamination in household air conditioners (ACs). Methods. fall of 2020, an survey living rooms was conducted 17 Japanese residences patients ABPM or related diseases. Household ductless...
Several serological tests for specific precipitin or IgG are available to demonstrate type III hypersensitivity reactions Aspergillus species and essential infectious fungal disease diagnosis. These assays also important allergic bronchopulmonary aspergillosis (ABPA) diagnosis; however, their concordance in ABPA was not well studied.Fifty-two patients diagnosed based on ISHAM criteria were enrolled. Precipitins fumigatus, niger, flavus, terreus measured using Ouchterlony double...
Although a microbiological diagnosis of pleural infection is clinically important, it often complicated by prior antibiotic treatment and/or difficulties with culturing some bacterial species. Therefore, we aimed to identify probable causative bacteria in empyema/parapneumonic effusions combining 16S ribosomal RNA (rRNA) gene amplification and next-generation sequencing (NGS). Pleural fluids were collected from 19 patients infectious nine non-infectious malignant effusions. We analysed DNA...
Abstract We report the first case of organizing pneumonia (OP) associated with a new coronavirus disease (COVID‐19) vaccination. A 78‐year‐old woman developed cough and dyspnoea 10 days after receiving BNT162b2. Chest computed tomography (CT) revealed consolidation in bilateral lower lobes lungs. Although antibiotic treatment did not improve her symptoms, she received second vaccination as scheduled. She was referred to our hospital because worsening on day 9 vaccination, reversed halo signs...
<i>Background:</i> Allergen sensitization through a disrupted skin barrier appears to play prominent role in the development of atopic diseases, including allergic asthma. The genetic background immunological and physiological phenotypes induced by epicutaneous is undetermined. <i>Methods:</i> BALB/c C57BL/6 mice were sensitized either epicutaneously patch application ovalbumin (OVA) or systemically intraperitoneal injection OVA with alum before exposure aerosolized...
Various volatile organic compounds (VOCs) are known to be toxic. Although exhaled VOC patterns change in obstructive sleep apnea (OSA) patients, individual profiles not fully determined. The primary outcome was characterizations; secondary outcomes included their relationships with and clinical parameters OSA patients. We prospectively examined 32 patients an apnea-hypopnea index (AHI) ≥ 15 by full polysomnography, 33 age- sex-matched controls without obvious symptoms. Nine severe were...
Although development of immune checkpoint inhibitors and various molecular target agents has extended overall survival time (OS) in advanced non-small cell lung cancer (NSCLC), a complete cure remains rare. We aimed to identify features treatment modalities remission (CR) cases stages III IV NSCLC by analyzing long-term survivors whose OS exceeded 3 years. From our hospital database, 1,699 patients, registered as between 1st Mar 2004 30th Apr 2011, were retrospectively examined. Stage or...