A5101587646- Respiratory Support and Mechanisms
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Medical Imaging and Pathology Studies
- Tracheal and airway disorders
- Cell Adhesion Molecules Research
- Nitric Oxide and Endothelin Effects
- Lung Cancer Research Studies
- Advanced Chemical Sensor Technologies
- Immune Response and Inflammation
- Obstructive Sleep Apnea Research
- Cancer Immunotherapy and Biomarkers
- Venous Thromboembolism Diagnosis and Management
- Colorectal Cancer Treatments and Studies
- CCD and CMOS Imaging Sensors
- Thin-Film Transistor Technologies
- Advanced Memory and Neural Computing
- Vascular Anomalies and Treatments
- Olfactory and Sensory Function Studies
- ZnO doping and properties
- Eicosanoids and Hypertension Pharmacology
- Neuroscience of respiration and sleep
Tokyo Medical University Hachioji Medical Center
2023-2025
Shimada Municipal Hospital
2024
Tokyo Medical University
2023
Tokai University
2012-2021
Semiconductor Energy Laboratory (Japan)
2004-2014
Saiseikai Central Hospital
2005
Keio University
1992-2004
Kitasato Institute Hospital
1997-2003
Taisho Pharmaceutical (Japan)
1998
Keio University Hospital
1994-1998
Although permissive hypercapnia improves the prognosis of patients with acute respiratory distress syndrome, it has not been conclusively determined whether hypercapnic acidosis (HA) is harmful or beneficial to sustained inflammation lung. The present study was designed explore molecular mechanism HA in modifying lipopolysaccharide (LPS)-associated signals pulmonary endothelial cells. LPS elicited degradation inhibitory protein kappaB (IkappaB)-alpha, but IkappaB-beta, resulting activation...
Exhaled volatile organic compounds (VOC) are being considered as biomarkers for various lungs diseases, including cancer. However, the accurate measurement of extremely low concentrations VOC in expired air is technically challenging. We evaluated clinical contribution exhaled measured with a new, double cold-trap method diagnosis lung cancer.Breath samples were collected from 116 patients histologically confirmed cancer and 37 healthy volunteers (controls) after inspiration purified air,...
Introduction The germinal center (GC) in lymph nodes plays an important role immune responses; however, their relevance to the effects of checkpoint inhibitor (ICI) remains unclear. relationship between GC and ICI efficacy is investigated this study. Materials methods This investigation included 16 non-small cell lung cancer (NSCLC) patients with postoperative recurrence who were treated inhibitors January 2016 April 2022. Patients categorized into two groups based on presence nodes....
Abstract Although c-Jun NH2-terminal kinase (JNK) has been implicated in the pathogenesis of transplantation-induced ischemia/reperfusion (I/R) injury various organs, its significance lung transplantation not conclusively elucidated. We therefore attempted to measure transitional changes JNK and AP-1 activities I/R-injured lungs. Subsequently, we assessed effects inhibition by three agents including SP600125 on degree means biological markers bronchoalveolar lavage fluid histological...
Yohei Kawaguchi, Nanako Nishioka, Taiyo Nakamura, Kentaro Imai, Takuya Aoki, Naohiro Kajiwara, Norihiko Ikeda
Severe or life-threatening asthma exacerbation is one of the worst outcomes because risk death. To date, few studies have explored potential heterogeneity this condition.To examine clinical characteristics and patients with severe exacerbation.This was a multicentre, prospective study pulse oxygen saturation < 90% who were admitted to 17 institutions across Japan. Cluster analysis performed using variables from patient- physician-orientated structured questionnaires.Analysis data 175...
Spontaneous pneumothorax shows a bimodal age distribution, with the secondary peak including patients aged ≥50 years. The purpose of this study was to clarify etiology and prognosis spontaneous in elderly.Patients years who were admitted tertiary university hospital between 2006 2016 due retrospectively investigated.Among 136 consecutive (mean age, 70 years; 114 men), 124 (91%) had underlying lung diseases, pulmonary emphysema (42%) interstitial pneumonia (27%). median period thoracic...
To elucidate the differential role of various adhesion molecules in distorting leukocyte behavior microvasculature hyperoxia-exposed rat lungs, we investigated fluorescein-labeled and erythrocyte kinetics isolated lungs taken from animals exposed to 90% O2 for 48 h under conditions which endothelial intercellular molecule-1 (ICAM-1) P-selectin were inhibited by appropriate monoclonal antibodies (1A29 ICAM-1 ARP2-4 P-selectin), while L-selectin was restrained with fucoidin. Measurements blood...
Reducing near-fatal asthma exacerbations is a critical problem in management.To determine patterns of factors preceding real-world setting.In nationwide prospective study 190 patients who had experienced exacerbation, cluster analysis was performed using symptoms over the 2-week period before admission.Three distinct clusters were defined employing self-reporting visual analogue scale. Cluster A (42.1%): rapid worsening within 7.4 hours from moderate attack to admission, young middle-aged...
Small-cell lung cancer (SCLC) shows high enhancer of zeste homolog 2 (EZH2) expressions. EZH2-mediated epigenetics promote epithelial-mesenchymal transition (EMT), enhancing invasive and metastatic potential in malignancies. MicroRNAs (miRNAs), small noncoding RNAs, modulate EMT, determining tumor phenotypes. However, the association between miRNAs EZH2 SCLC remains to be clarified-we aimed identify a novel tumorigenic mechanism through miRNAs, EZH2, EMT SCLC, leading future therapeutic applications.
Intercellular adhesion molecule-1 (ICAM-1) of the vascular endothelium plays a key role in development pulmonary oxygen toxicity. We studied effect steroid on hyperoxia-induced ICAM-1 expression using cultured endothelial cells vitro. Human artery (HPAECs) were to confluence, and then monolayers exposed either control (21% O(2)-5% CO(2)) or hyperoxic (90% conditions with without synthetic glucocorticoid, methylprednisolone (MP). MP reduced mRNA dose-dependent manner. Neutrophil...
Abstract —To elucidate the differential reactivity of pulmonary microvessels in acini to hypoxia, excessive CO 2 , and increased H + we investigated changes diameter precapillary arterioles, postcapillary venules, capillaries isolated rat lungs on exposure normocapnic hypoxia (2% O ), normoxic hypercapnia (15% isocapnic acidosis (0.01 mol/L HCl). Microvascular diameters were precisely examined using a real-time confocal laser scanning luminescence microscope coupled high-sensitivity camera...
Various volatile organic compounds (VOCs) are known to be toxic. Although exhaled VOC patterns change in obstructive sleep apnea (OSA) patients, individual profiles not fully determined. The primary outcome was characterizations; secondary outcomes included their relationships with and clinical parameters OSA patients. We prospectively examined 32 patients an apnea-hypopnea index (AHI) ≥ 15 by full polysomnography, 33 age- sex-matched controls without obvious symptoms. Nine severe were...
With the use of isolated perfused rabbit lungs (n = 152), roles endothelium-derived relaxing factor (EDRF) in pulmonary vascular responses to hypocapnia and hypercapnia were studied. Lungs ventilated with a gas mixture containing 1, 5, or 10% CO2 21% O2, adjusting perfusate pH 7.8, 7.4, 7.1, respectively. Methemoglobin (MetHb), hemoglobin (Hb), methylene blue (MB), L-argininosuccinic acid (L-ASA) used as modulators EDRF. To eliminate augmented shear stress, we papaverine during hypercapnia....
This study aimed to examine the behavior of stimulated leukocytes in pulmonary microcirculation. The leukocyte-endothelium interaction was visualized under physiological shear rates perfused rat lungs using high-speed confocal laser video microscopy. Leukocytes labeled with carboxyfluorescein were cytokine-induced neutrophil chemoattractant (CINC/gro), which caused L-selectin shedding and inverse upregulation CD18. Neither unstimulated nor exhibited rolling either arterioles or venules,...
Although development of immune checkpoint inhibitors and various molecular target agents has extended overall survival time (OS) in advanced non-small cell lung cancer (NSCLC), a complete cure remains rare. We aimed to identify features treatment modalities remission (CR) cases stages III IV NSCLC by analyzing long-term survivors whose OS exceeded 3 years. From our hospital database, 1,699 patients, registered as between 1st Mar 2004 30th Apr 2011, were retrospectively examined. Stage or...
To investigate the pathogenesis of pulmonary oxygen toxicity, we examined effect hyperoxia on adhesion molecule expression in cultured human artery endothelial cells (HPAEC) and umbilical vein (HUVEC). Endothelial cell monolayers were exposed to either hyperoxic (90% O(2)-5% CO(2)) or normoxic (21% conditions for various periods. The level intercellular (ICAM)-1 had increased hyperoxia-exposed HPAEC HUVEC at 48 h (194 +/- 38 233 56%, respectively; P < 0.001) 72 (200 43 223 52%, compared with...
The hydrogen ion is an important factor in the alteration of vascular tone pulmonary circulation. Endothelial cells modulate by producing vasoactive substances such as prostacyclin (PGI2) through a process depending on intracellular Ca2+ concentration ([Ca2+]i). We studied influence CO2-related pH changes [Ca2+]i and PGI2 production human artery endothelial (HPAECs). Hypercapnic acidosis appreciably increased from 112 +/- 24 to 157 38 nmol/l. Intracellular acidification at normal...
As density of VLSI devices continues to increase at a rapid rate, extensive efforts are being made in development fine pitch wirebond for IC packages utilize higher U0 bonds required recent fme applications, the effect probe mark under ball is counts while shrinking chip sizes. With small size