A5101981943- Cancer-related Molecular Pathways
- Pancreatic and Hepatic Oncology Research
- Inflammatory Bowel Disease
- Acute Lymphoblastic Leukemia research
- Metabolism, Diabetes, and Cancer
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Cell death mechanisms and regulation
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- Hepatitis C virus research
- Cancer therapeutics and mechanisms
- Immunodeficiency and Autoimmune Disorders
- Cancer Mechanisms and Therapy
- Protease and Inhibitor Mechanisms
- Metal Extraction and Bioleaching
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Infection Control and Ventilation
- Microscopic Colitis
- Dental materials and restorations
- Gastric Cancer Management and Outcomes
- Wnt/β-catenin signaling in development and cancer
- Biochemical and Molecular Research
- Mosquito-borne diseases and control
Kitasato Institute Hospital
2015-2024
Kitasato University
2015-2024
Kobe Material Testing Laboratory (Japan)
2024
Osaka Dental University
2006-2020
Keio University
2003-2017
University of Florida
2016
Columbus Oncology and Hematology Associates
2016
Reckitt Benckiser (United States)
2016
Biomedical Research Institute
2014
GTx (United States)
2012
Although permissive hypercapnia improves the prognosis of patients with acute respiratory distress syndrome, it has not been conclusively determined whether hypercapnic acidosis (HA) is harmful or beneficial to sustained inflammation lung. The present study was designed explore molecular mechanism HA in modifying lipopolysaccharide (LPS)-associated signals pulmonary endothelial cells. LPS elicited degradation inhibitory protein kappaB (IkappaB)-alpha, but IkappaB-beta, resulting activation...
Although many therapeutic options are available for inflammatory bowel disease (IBD), 5-aminosalicylic acid (5-ASA) is still the key medication, particularly ulcerative colitis (UC). However, mechanism of action 5-ASA remains unclear. The intestinal microbiota plays an important role in pathophysiology IBD, and we hypothesized that alters microbiota, which promotes anti-inflammatory effect 5-ASA. Because inflammation affects gut can change severity inflammation, assessing impact on not...
The efficacy of gemcitabine (GEM), a standard treatment agent for pancreatic cancer, is insufficient because primary or acquired resistance to this drug. Patients with tumors intrinsically sensitive GEM gradually acquire and require shift second agents, which are associated the risk cross-resistance. However, whether cross-resistance actually present has long been disputed. Using six GEM-resistant four highly clones derived from cancer cell line BxPC-3, we determined each clone parent...
Intercellular adhesion molecule-1 (ICAM-1) of the vascular endothelium plays a key role in development pulmonary oxygen toxicity. We studied effect steroid on hyperoxia-induced ICAM-1 expression using cultured endothelial cells vitro. Human artery (HPAECs) were to confluence, and then monolayers exposed either control (21% O(2)-5% CO(2)) or hyperoxic (90% conditions with without synthetic glucocorticoid, methylprednisolone (MP). MP reduced mRNA dose-dependent manner. Neutrophil...
Second-generation colon capsule endoscopy (CCE-2) has been reported as a potential tool for monitoring ulcerative colitis (UC). However, its excretion rate is still unsatisfactory, and the bowel preparation regimen not well tolerated. Furthermore, standard validated UC established. The aim of this study was to develop simple 1-day CCE-2 procedure while evaluating acceptability in UC. Factors associated with colonic transit time were evaluated. Thirty-three patients prospectively Five hundred...
Abstract EGFR mutation-positive patients with non–small cell lung cancer (NSCLC) respond well to treatment EGFR–tyrosine kinase inhibitors (EGFR–TKI); however, EGFR–TKIs is not curative, owing the presence of residual cells intrinsic or acquired resistance this class drugs. Additional targets that may enhance efficacy remain elusive. Using a CRISPR/Cas9-based screen, we identified leucine-rich repeat scaffold protein SHOC2 as key modulator sensitivity EGFR–TKI treatment. On basis in vitro...
Methotrexate (MTX) is currently the anchor drug widely used worldwide in treatment of rheumatoid arthritis (RA). However, therapeutic response to MTX has been shown vary among individuals, genders and ethnic groups. The reason for this not clarified but it considered be partially due several mechanisms cellular pathway including single-nucleotide polymorphisms (SNPs). purpose study was investigate allelic frequencies different and/or population groups 10 enzyme proteins transporters related...
The treatment of pancreatic cancer remains a significant clinical challenge due to the limited number patients eligible for curative (R0) surgery, failures in development targeted and immune therapies, pervasive acquisition chemotherapeutic resistance. Refractory is typified by high invasiveness resistance therapy, with both attributes related tumor cell stemness. These malignant characteristics mutually enhance each other, leading rapid progression. Over past two decades, numerous studies...
Introduction Hand hygiene is an infection control measure for COVID-19 in our daily lives; however, the contamination levels of SARS-CoV-2 hands healthy individuals remain unclear. Thus, we aimed to evaluate by detecting viral RNA and viable viruses samples obtained from 925 individuals. Methods Swab were collected palms fingers participants, including office workers, public officers, university students, faculty staff, hospital staff between December 2022 March 2023. The swab analyzed using...
Metformin (MET) is the first‑line treatment for type 2 diabetes mellitus. Several epidemiological studies have suggested potential anti‑cancer effects of MET, including its activity against pancreatic ductal adenocarcinoma (PDAC). Gemcitabine (GEM) has become standard chemotherapy PDAC; however, acquired resistance to GEM a major challenge. In this study, we evaluated anti‑tumor MET GEM‑resistant PDAC in mouse xenograft model. BxG30 cells were implanted into BALB/c nude mice. The mice...
Thiopurines are often used in combination with mesalazine for the treatment of ulcerative colitis (UC). Mesalazine formulations delivered to digestive tract by various delivery systems and absorbed as 5-aminosalicylic acid (5-ASA). 5-ASA is known inhibit thiopurine S-methyltransferase (TPMT) activity affect metabolism. There have been no studies comparing TPMT inhibition multimatrix (MMX) other formulations. We investigated difference different prospectively confirmed clinical...
To investigate the pathogenesis of pulmonary oxygen toxicity, we examined effect hyperoxia on adhesion molecule expression in cultured human artery endothelial cells (HPAEC) and umbilical vein (HUVEC). Endothelial cell monolayers were exposed to either hyperoxic (90% O(2)-5% CO(2)) or normoxic (21% conditions for various periods. The level intercellular (ICAM)-1 had increased hyperoxia-exposed HPAEC HUVEC at 48 h (194 +/- 38 233 56%, respectively; P < 0.001) 72 (200 43 223 52%, compared with...
Abstract Acquisition of resistance to gemcitabine is a challenging clinical and biological hallmark property refractory pancreatic cancer. Here, we investigated whether glycogen synthase kinase (GSK)‐3β, an emerging therapeutic target in various cancer types, mechanistically involved acquired human This study included 3 gemcitabine‐sensitive BxPC‐3 cell‐derived clones (BxG30, BxG140, BxG400) that stepwise overexpressed ribonucleotide reductase (RR)M1. Treatment with GSK3β‐specific inhibitor...
In a previous study, we showed that combination of an oral fluoropyrimidine anticancer agent (S-1) and gemcitabine (GEM) had synergistic effects on cell growth cycle arrest in the pancreatic cancer line MIA PaCa-2. Therefore, conducted further mechanistic studies using lines PaCa-2 SUIT-2. The combined effect S-1 GEM SUIT-2 cells was evaluated 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, S-1, plus regulation were assessed flow cytometry. We also examined...
The composite cold pellet consisted of manganese ore, iron fine coke and ferro-manganese slag based on their charging ratio at the silico-manganese production in an electric furnace was produced without additional binders by a pilot plant.The physical properties produced, such as decrepitation, reduction disintegration, reducibility resistivity were remarkably improved comparison with original ore.Only one thirds energy ordinary firing agglomeration process is expected to be required...
Human CD46 is a receptor for the M protein of group A streptococcus (GAS). The emm1 GAS strain GAS472 was isolated from patient suffering streptococcal toxic shock-like syndrome. CD46-expressing transgenic (Tg) mice developed necrotizing fasciitis associated with osteoclast-mediated progressive and severe bone destruction in hind paws 3 days after subcutaneous infection 5 × 10(5) colony-forming units GAS472. induced expression activator nuclear factor-κB ligand (RANKL) while concomitantly...
Clarifying the presence of viable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rather than SARS-CoV-2 viral RNA in inpatient rooms is important for infection control disease 2019 (COVID-19). In this study, we investigated levels and virus on environmental surfaces patient saliva.
Abstract Sex differences in the prevalence of autoimmune diseases such as rheumatoid arthritis (RA) are well known, but little is known about those relation to therapeutic response. Reduced folate carrier‐1 (RFC‐1), folypolyformyl glutamate synthase (FPGS), and γ‐glutamyl hydrolase (GGH) important transporters enzymes that convert methotrexate (MTX) body. This study investigated sex mRNA expression RFC‐1, FPGS, GGH 190 unrelated healthy Japanese people. The genotypes were determined using...