A5103164856- Helicobacter pylori-related gastroenterology studies
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Eosinophilic Esophagitis
- Galectins and Cancer Biology
- Veterinary medicine and infectious diseases
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Gastrointestinal motility and disorders
- Pituitary Gland Disorders and Treatments
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Hormonal Regulation and Hypertension
- Cardiovascular Disease and Adiposity
- Microbial Metabolites in Food Biotechnology
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Gastrointestinal disorders and treatments
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Heart Failure Treatment and Management
- Cancer-related gene regulation
- Probiotics and Fermented Foods
- Cardiac Valve Diseases and Treatments
Saiseikai Fukuoka General Hospital
2015-2024
Nippon Medical School Hospital
2016-2024
Chiba Hokusou Hospital
2024
Tokai University
2011-2021
Juntendo University
2009-2021
The Japanese Society of Gastroenterological Surgery
2016-2021
Nippon Medical School
2007-2020
Tokai University Hospital
2016-2017
Shibuya University Network
2016
Tokyo Women's Medical University
2006-2015
Background —Little is known regarding intravascular ultrasound (IVUS) criteria to determine the functional severity of coronary stenosis. Recently, fractional flow reserve (FFR) has emerged as a lesion-specific index stenosis that independent systemic hemodynamic variability. The present study was undertaken IVUS parameters for physiological Methods and Results —Fifty-one lesions in 42 patients were evaluated by means quantitative angiogram, IVUS, intracoronary pressure measurements. FFR...
A direct radioimmunoassay for serum aldosterone was developed using a highly specific sntibody and 8-anilino-1-naphthalene sulfonic acid as blocking agent to inhibit the binding of proteins. 125I-labeled used labeled antigen polyethylene glycol separate antibody-bound free aldosterone. The minimum detectable concentration 1.5 pg/tube. There were excellent correlations between present method other methods, i.e., 1) tritiated aldosterone, 2) dichloromethane extraction before assay, 3)...
The objective of this study was to investigate comparatively the influence proton-pump inhibitors (PPI) administration on three bacterial communities in oral cavity, stomach, and colon along alimentary tract.Forty-five subjects including 18 patients taking PPI were enrolled. Stimulated saliva, gastric fluid (GF), feces obtained from each subject for microbiota analysis through 16S rRNA gene profiling using pyrosequencing method.The species richness (alpha diversity) similar among these...
OBJECTIVE Eradication of Helicobacter pylori was reported to increase the platelet counts in some H. pylori-positive patients with chronic idiopathic thrombocytopenic purpura (cITP). However, efficacy eradication quite different according previous reports. To determine whether infection can contribute cITP, we performed a randomized controlled trial for first time. In addition, investigate possible pathogenic mechanisms and predict response after each cITP patient, several virulence factors,...
<h3>Objective:</h3> To determine the incidence of sudden cardiac death (SCD) according to left ventricular ejection fraction (LVEF) in survivors myocardial infarction (MI) primary percutaneous coronary intervention (PCI) era. <h3>Design:</h3> A multicentre observational prospective registered cohort study. <h3>Setting:</h3> 18 medical centres Japan. <h3>Patients:</h3> 4122 consecutive patients (mean age 66 (SD 12) years, 73.7% male) with acute MI, who were discharged alive. <h3>Main outcome...
Limited data exists on ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) managed by a well-organized cardiac care network in metropolitan area. We analyzed the Tokyo CCU database 2009-2010. Of 4329 acute (AMI) patients including STEMI (n = 3202) NSTEMI 1127), percutaneous coronary intervention (PCI) was performed 88.8 % of 70.4 patients. Mean onset-to-door door-to-balloon times were shorter than those (167 vs 233 60 145 min, respectively, p < 0.001). Coronary artery...
<b><i>Background/Aims:</i></b> Probiotics appear to improve <i>Helicobacter pylori</i>-associated dyspepsia via an inhibitory effect on <i>H. pylori;</i> however, uncertainty exists regarding their effects in pylori</i>-uninfected individuals. We evaluated the efficacy of <i>Lactobacillus gasseri</i> OLL2716 (<i>L. OLL2716) individuals with functional (FD). <b><i>Methods:</i></b> A double-blind,...
ABSTRACT Objective. Although curative treatment of Helicobacter pylori infection markedly reduces the relapse peptic ulcers, details ulcers that do recur is not well characterized. The aim this study to describe recurrence rate and specific features after cure H. infection. Methods. This was a multicenter involving 4940 ulcer patients who were negative successful eradication followed for up 48 months. annual incidence in ‐cured patients, background with relapsed time relapse, size, site...
Abstract Bacteroides , a predominant commensal bacteria in the gut, are thought to be responsible for development of inflammatory bowel disease (IBD). In present study, we examined whether or not bifidobacteria suppress B. vulgatus representative pathogenic species, both coculture system and gnotobiotic murine model. As result, Bifidobacterium infantis 1222 highly inhibited growth also significantly suppressed systemic antibody response raised by colonizing gut mice. Colonization mice...
Helicobacter pylori eradication clearly decreases peptic ulcer recurrence rates. H. is achieved in 70-90% of cases, but treatment failures due to poor patient compliance and resistant organisms do occur. Lactobacillus gasseri can suppress both clarithromycin-susceptible -resistant strains vitro. The aim this study was determine the effect pretreatment with L. gasseri- containing yogurt on eradication. We conducted a randomized, controlled clinical trial patients infection.A total 229 were...
To investigate the influence of antimicrobials on both gut microbiota structure and plasma ghrelin level using Helicobacter pylori-infected patients who underwent eradication therapy.Twenty H. (mean age 68.3 years old) therapy participated in study. For therapy, had 1 week triple consisting amoxicillin, clarithromycin proton-pump inhibitors. Stool blood samples were obtained before (S1), immediately after (S2) and/or 3 months (S3) therapies. The concentrations leptin assayed an ELISA. V3-V4...
Aims HMG‐CoA reductase inhibitors (statins) have been demonstrated to in vitro vascular effects. The aim of this study was determine whether statins actually vivo effects independent their cholesterol‐lowering effect. Methods We investigated the effect a single dose cerivastatin on endothelial function by measuring flow‐mediated dilatation brachial artery ultrasound 30 healthy volunteers with normal serum cholesterol concentrations. They were randomized either placebo group ( n = 15) or 15),...
To clarify what bacterial species of commensal intestinal microbes are recognized as the antigens that induce a serum antibody response in patients with inflammatory bowel disease (IBD), 72 subjects consisting 12 Crohn's patients, 30 ulcerative colitis and healthy volunteers were examined for their titers to these bacteria. In IBD result, significant elevations both immunoglobulin G (IgG) IgA Bacteroides ovatus found. Immunoblotting showed definite 19.5-kDa band B. was bound raised patients....
Abstract Background and Aim: We compared endoscopic findings of the frequency scale for symptoms gastroesophageal reflux disease (FSSG), a written questionnaire developed in Japan, to that diagnosis esophagitis (QUEST) esophagitis. Methods: registered 475 patients with untreated upper abdominal pain (male/female: 252/223, average age 52.4 ± 17.8 years). Subjects were assessed first FSSG QUEST questionnaires, then by endoscopy, before allocation gastric ulcer (GU), duodenal (DU), (GERD) or...
The long-term prognosis of diabetic patients with acute myocardial infarction (AMI) treated by revascularization is uncertain, and the optimal pharmacotherapy for such cases has not been fully evaluated.To elucidate prognostic factors in AMI, a prospective, cohort study involving 3021 consecutive AMI was conducted. All discharged alive from hospital were followed to monitor their every year. primary endpoint all-cause mortality, secondary occurrence major cardiovascular events. To effect...
Epidermal hyperplasia is a histological hallmark observed in both atopic dermatitis (AD) and psoriasis, although the clinical features underlying immunological disorders of these diseases are different. We previously showed that periostin, matricellular protein, plays critical role epidermal AD, using mouse model 3-dimensional organotypic coculture system. In this study, we explore hypothesis periostin involved psoriasis. To examine expression psoriasis patients, performed...
<b>Background:</b> Alopecia areata (AA) is considered as a T-cell mediated autoimmune disorder. The 308-nm excimer laser thought to be capable of inducing apoptosis <i>in vitro</i>, suggesting that the lamp (not laser) might effective for treatment AA. We examined effectiveness treating <b>Materials and Methods:</b> treated 16 patients with single AA multiple (MAA). lesions were irradiated at 2-week intervals. <b>Results:</b> Hair regrowth was observed in 14 patients. Among them, 10 showed...
<b><i>Background:</i></b> Although there is evidence about the beneficial effects of probiotics, their on aspirin-induced small bowel injuries have not been well examined. We evaluated probiotic <i>Lactobacillus gasseri </i>OLL2716 (LG) intestinal lesions, such as ulcers, erosions, reddened and bleeding. <b><i>Summary:</i></b> This study enrolled 64 patients who received aspirin for more than 1 month provided written informed...
Background Determination of fractional flow reserve (FFR) has been proposed as a means to assess stent deployment. In this prospective, multicenter trial, we evaluate the use FFR optimize stenting by comparing it with standard intravascular ultrasound (IVUS) criteria. Methods and Results Eighty-four stable patients isolated coronary lesions underwent deployment starting at 10 atm increased serially 2 until was ≥0.94 or 16 achieved. IVUS then performed. measured pressure wire intracoronary...
Clarithromycin (CAM)-resistant Helicobacter pylori sometimes offers serious problems with eradication by antibiotics. The aim of this study was to determine whether a probiotic can be an alternative therapy in CAM-resistant Hp infection.The effects Lactobacillus gasseri (strain OLL2716) on the growth CAM-susceptible and H. interleukin (IL)-8 production provoked these strains were examined vitro experiments. Moreover, mice infected or pylori, treated CAM L. gasseri.In experiments demonstrated...