A5070500071- Helicobacter pylori-related gastroenterology studies
- Inflammatory mediators and NSAID effects
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Gastrointestinal Tumor Research and Treatment
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Microscopic Colitis
- Inflammatory Bowel Disease
- Esophageal and GI Pathology
- Atrial Fibrillation Management and Outcomes
- Diverticular Disease and Complications
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Liver Disease and Transplantation
- Potassium and Related Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Cytokine Signaling Pathways and Interactions
- Drug-Induced Adverse Reactions
- Pathogenesis and Treatment of Hiccups
New Tokyo Hospital
2024
University of Tsukuba Hospital
2013-2022
University of Tsukuba
2010-2021
Saba University School of Medicine
2020
The Japanese Society of Gastroenterological Surgery
2016-2020
Showa University
2020
Showa University Koto Toyosu Hospital
2020
Jikei University School of Medicine
2020
Iwate Medical University
2020
Kyoto Prefectural University of Medicine
2017-2019
Fusobacterium varium may contribute to ulcerative colitis (UC). We conducted a double-blind placebo-controlled multicenter trial determine whether antibiotic combination therapy induces and/or maintains remission of active UC.Patients with chronic mild-to-severe relapsing UC were randomly assigned oral amoxicillin 1500 mg/day, tetracycline and metronidazole 750 vs. placebo, for 2 weeks, then followed up. The primary study end point was clinical response (Mayo score at 3 months after...
Compare efficacy and safety of vonoprazan lansoprazole for secondary prevention low-dose aspirin (LDA)-associated peptic ulcers in a 24-week study long-term extension therapy separate study.Double-blind, randomised, non-inferiority study; single-blind at 104 Japanese sites, including 621 patients (439 extension) with history who required LDA therapy. Randomised (1:1:1, computer generated) received 15 mg (n=217), 10 (n=202) or 20 once daily 24 weeks (double blind) ≤2 years (extension). The...
Objective To assess the non-inferiority of vonoprazan to lansoprazole for secondary prevention non-steroidal anti-inflammatory drug (NSAID)-induced peptic ulcer (PU) and safety during extended use. Design A phase 3, 24-week, multicenter, randomised, double-blind (DB), active-controlled study, followed by a ≥28 week, single-blind, parallel-group extension study (EXT) in outpatients (n=642) receiving long-term NSAID therapy who are at risk PU recurrence. The patients received (10 mg or 20 mg)...
Sulforaphane (SFN) plays an important role in preventing oxidative stress by activating the nuclear factor (erythroid derived 2)-like 2 (Nrf2) signalling pathway. SFN may improve exercise endurance capacity counteracting stress-induced damage during exercise. We assessed running ability based on exhaustive treadmill test (progressive-continuous all-out) and examined expression of markers for muscle damage. Twelve- to 13-week-old Male wild-type mice (Nrf2 +/+) Nrf2-null -/-) C57BL/6J...
The efficacy of low-dose lansoprazole has not been established for the prevention recurrent gastric or duodenal ulcers in those receiving long-term aspirin (LDA) cardiovascular and cerebrovascular protection. This study sought to examine (15 mg once daily) secondary LDA-associated ulcers.Patients were randomized receive 15 daily (n = 226) gefarnate 50 twice 235) 12 months longer a prospective, multicenter, double-blind, active-controlled trial, followed by 6-month follow-up with open-label...
Background & AimsWe previously reported results from a prospective randomized controlled trial comparing the efficacy of adalimumab monotherapy versus combination with azathioprine for patients Crohn's disease (CD) who were naive to biologics and thiopurines. We performed subanalysis data this study evaluate factors associated endoscopic response mucosal healing in participants.MethodsWe compared simple scores CD between moderate severe active randomly assigned groups that received (n = 85)...
<b>Background and study aims:</b> Colonic diverticular hemorrhage is the most common cause of lower intestinal bleeding. We tried to develop a convenient reliable hemostatic method, endoscopic detachable snare ligation (EDSL), treat retrospectively explored its safety efficacy. <b>Patients methods:</b> The definitive bleeding diverticulum was ligated with snare, instead rubber band, in procedure similar band ligation. Removal scope attach device reinsertion for treatment are not needed this...
VEGF is a highly specific stimulator of endothelial cells and may play an important role in angiogenesis the process tissue regeneration. We previously showed that cyclooxygenase-2 (COX-2) expressed mesenchymal ulcer bed involved repair process. To clarify COX-2 during gastric healing, we investigated relation between expression production human fibroblasts vivo vitro. Gastric were cultured RPMI 1640 with without IL-1alpha or IL-1beta presence absence NS-398, selective inhibitor. Supernatant...
To investigate the clinical differences between small intestinal injuries in low-dose aspirin (LDA) users and non-steroidal anti-inflammatory drug (NSAID) who were examined by capsule endoscopy (CE) for obscure gastrointestinal bleeding (OGIB).A total of 181 patients underwent CE OGIB included this study. Based on records, laboratory data such as hemoglobin levels, major symptoms, underlying diseases, types duration LDA NSAID use, endoscopic characteristics reviewed.Out a 45 cases erosive...
Introduction Indigo naturalis (IN) is a blue pigment extracted from Assam indigo and other plants has been confirmed to be highly effective for ulcerative colitis (UC) treatment in several clinical studies. Objective We conducted multicenter double-blind study confirm the efficacy safety of short-term IN administration. Methods A multicenter, randomized controlled trial was between December 2015 October 2018 our facilities. Forty-six patients with mild moderate active UC (Lichtiger index:...
Abstract Gastrointestinal (GI) bleeding control is critical in elderly patients with atrial fibrillation (AF) receiving oral anticoagulants (OAC). This subgroup analysis aimed to clarify the actual state and significance of GI non-valvular AF (NVAF) patients. We evaluated incidence risk factors during 2-year follow-up examined impact on mortality. Of 32,275 ANAFIE Registry, 1139 (3.5%) experienced (incidence rate, 1.92 events per 100 person-years; mean follow-up, 1.88 years); 339 upper 760...
Low-dose lansoprazole has not been intensively evaluated for its efficacy in the prevention of recurrent gastric or duodenal ulcers patients receiving long-term non-steroidal anti-inflammatory drug (NSAID) therapy pain relief such diseases as rheumatoid arthritis, osteoarthritis, and low back pain. This multi-center, prospective, double-blind, randomized, active-controlled study involving 99 sites Japan was designed to compare (15 mg daily) with gefarnate (50 twice daily). Patients a history...
Background/Aims: Recently, endoscopic detachable snare ligation (EDSL) has become increasingly common as treatment for colonic diverticular hemorrhage. This study aimed to evaluate the efficacy and safety of EDSL in comparison with clipping (EC) Methods: From April 2013 September 2017, 131 patients were treated or EC at Tokyo Metropolitan Bokutoh Hospital. We retrospectively evaluated patient characteristics clinical outcomes, including early rebleeding rates (rebleeding within 30 days after...
Exercise can be hypothesized to play an important role in non-alcoholic fatty liver disease (NAFLD) treatment by changing the oral bacterial flora and mechanism underlying periodontal disease. We performed salivary component analysis before after exercise regimen, genome of elucidate mechanism. Obese middle-aged men with NAFLD were allocated 12-week (n = 49) or dietary restriction 21) groups. collected saliva compare microflora; predictive metagenomic functions; and, measured immunoglobulin...
Aim: The effect of dietary cholesterol on plasma concentrations varies widely among individuals. Recent studies suggest that the synthesis oxysterols is up‐regulated when tissue saturated. present study was undertaken to test hypothesis a serum high concentration 27‐hydroxycholesterol, one oxysterols, reflects positive balance in body and predicts intolerance high‐cholesterol diet. Methods: In 30 subjects, 750 mg/day added for 4 weeks ordinary Blood samples were collected at start finish...