Toshiaki Narasaka
A5033927829- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Diverticular Disease and Complications
- Metastasis and carcinoma case studies
- Helicobacter pylori-related gastroenterology studies
- Esophageal and GI Pathology
- Colorectal Cancer Screening and Detection
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Galectins and Cancer Biology
- Estrogen and related hormone effects
- Pancreatitis Pathology and Treatment
- Eosinophilic Esophagitis
- Inflammatory mediators and NSAID effects
- Hospital Admissions and Outcomes
- Diagnosis and treatment of tuberculosis
- Gastroesophageal reflux and treatments
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Protease and Inhibitor Mechanisms
- Neuroblastoma Research and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
University of Tsukuba Hospital
2016-2025
University of Tsukuba
2014-2024
Suzuki (Japan)
2024
Weatherford College
2024
American Society for Gastrointestinal Endoscopy
2022
Tokyo Medical University
2003-2011
Hyogo Medical University
2005
Kasumigaura Medical Center
1997-2003
Tohoku University
2001
Objective Bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is a frequent adverse event ESD. We aimed to develop and externally validate clinically useful prediction model (BEST-J score: ESD Trend from Japan) bleeding EGC. Design This retrospective study enrolled patients who underwent Patients in the derivation cohort (n=8291) were recruited 25 institutions, external validation (n=2029) eight institutions other areas. In cohort, weighted points assigned...
INTRODUCTION: The bleeding source of hematochezia is unknown without performing colonoscopy. We sought to identify whether colonoscopy a risk-stratifying tool etiology and predict outcomes presenting symptoms can differentiate the etiologies in patients with hematochezia. METHODS: This multicenter retrospective cohort study conducted at 49 hospitals across Japan analyzed 10,342 admitted for outpatient-onset acute RESULTS: Patients were mostly elderly population, 29.5% had hemodynamic...
Abstract Background Direct and indirect clipping treatments are used worldwide to treat colonic diverticular bleeding (CDB), but their effectiveness has not been examined in multicenter studies with more than 100 cases. Objective We sought determine the short‐ long‐term of direct versus for CDB a nationwide cohort. Methods studied 1041 patients who underwent ( n = 360) or 681) at 49 hospitals across Japan (CODE BLUE‐J Study). Results Multivariate analysis adjusted age, sex, important...
<b>Background and study aims:</b> Colonic diverticular hemorrhage is the most common cause of lower intestinal bleeding. We tried to develop a convenient reliable hemostatic method, endoscopic detachable snare ligation (EDSL), treat retrospectively explored its safety efficacy. <b>Patients methods:</b> The definitive bleeding diverticulum was ligated with snare, instead rubber band, in procedure similar band ligation. Removal scope attach device reinsertion for treatment are not needed this...
Currently, large, nationwide, long-term follow-up data on acute lower gastrointestinal bleeding (ALGIB) are scarce. We investigated risks of recurrence after hospital discharge for ALGIB using a large multicenter dataset.
The study aimed to identify prognostic factors for patients with acute lower gastrointestinal bleeding and develop a high-accuracy prediction tool. analysis included 8254 cases of hematochezia who were admitted urgently based on the judgment emergency physicians or gastroenterology consultants (from CODE BLUE J-study). Patients randomly assigned derivation cohort validation in 2:1 ratio using random number table. Assuming that present at time admission are involved mortality within 30 days...
Background and AimsWe aimed to determine the optimal timing of colonoscopy factors that benefit patients who undergo early for acute lower GI bleeding.MethodsWe identified 10,342 with hematochezia (CODE BLUE-J study) admitted 49 hospitals in Japan. Of these, 6270 underwent a within 120 hours were included this study. The inverse probability treatment weighting method was used adjust baseline characteristics among (≤24 hours, n = 4133), elective (24-48 1137), late (48-120 1000) colonoscopy....
We investigated the factors associated with synchronous multiple early gastric cancers and determined their localization.
Background/Aims: Recently, endoscopic detachable snare ligation (EDSL) has become increasingly common as treatment for colonic diverticular hemorrhage. This study aimed to evaluate the efficacy and safety of EDSL in comparison with clipping (EC) Methods: From April 2013 September 2017, 131 patients were treated or EC at Tokyo Metropolitan Bokutoh Hospital. We retrospectively evaluated patient characteristics clinical outcomes, including early rebleeding rates (rebleeding within 30 days after...
Ligation therapy, including endoscopic detachable snare ligation (EDSL) and band (EBL), has emerged as an treatment for colonic diverticular bleeding (CDB); its comparative effectiveness risk of recurrent remain unclear, however. Our goal was to compare the outcomes EDSL EBL in treating CDB identify factors after therapy.We reviewed data 518 patients with who underwent (n = 77) or 441) a multicenter cohort study named Colonic Diverticular Bleeding Leaders Update Evidence From Multicenter...
ObjectiveDestruction of the extracellular matrix is essential for tumor invasion and metastasis. The relationship between Helicobacter pylori (H. pylori) infection destruction not yet clear. Urokinase-type plasminogen activator (uPA) plays an important role in basement membrane. receptor (uPAR) inhibitor-1(PAI-1) appear to be associated with these processes. To clarify H. processes membrane cancerous tissue, effect on expressions uPA, uPAR PAI-1 cancer cells was investigated.Material...
As the aging of people in a society advances, number elderly patients older than 80 years Japan with gastric cancer continues to increase. Although delayed ulcer bleeding is major adverse event after endoscopic submucosal dissection (ESD), little known about characteristic risk factors for undergoing ESD. This study aimed evaluate ESD years.We retrospectively evaluated incidence 10,320 early-stage resected by between November 2013 and January 2016 at 33 Japanese institutions investigated...
Abstract Background The value of endoscopy for acute lower GI bleeding (ALGIB) remains unclear, given few large cohort studies. We aim to provide detailed clinical data ALGIB management and identify patients at risk adverse outcomes based on endoscopic diagnosis. Methods conducted a multicenter, retrospective study, named CODE BLUE J-Study, in 49 hospitals throughout Japan studied 10,342 cases admitted outpatient-onset hematochezia. Results Cases were mostly elderly, with 29.5% hemodynamic...
This study aimed to reveal the timing of bleeding and thromboembolism associated with endoscopic submucosal dissection (ESD) for early gastric cancer (EGC).We retrospectively reviewed 10,320 patients who underwent ESD EGC during November 2013-October 2016. We evaluated overall rates their inter-group differences. Factors early/late (cut-off 5 days) frequency its association intake antithrombotic agents were investigated.Overall, post-ESD rate was 4.7% (489/10 320); median time 4 days. The...