A5050160343- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Metastasis and carcinoma case studies
- Inflammatory Bowel Disease
- Microscopic Colitis
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Nutrition and Health in Aging
- Dysphagia Assessment and Management
- Eosinophilic Esophagitis
- Esophageal Cancer Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal disorders and treatments
- Gastrointestinal motility and disorders
- Pelvic floor disorders treatments
- Sexual function and dysfunction studies
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Dermatology and Skin Diseases
- Pancreatitis Pathology and Treatment
- Hepatitis C virus research
- Abdominal vascular conditions and treatments
- Sleep and related disorders
- Cancer Mechanisms and Therapy
Ehime University Hospital
2021-2025
Ehime Prefectural Central Hospital
2015-2024
Ehime University
2018-2024
Sumitomo Besshi Hospital
2024
Saiseikai Ibaraki Hospital
2024
Keio University
2024
National Institute of Technology, Niihama College
2024
Evidence (Italy)
2023
Michigan Department of Education
2023
American Urological Association
2023
The Child-Pugh classification has some non-objective factors, with chronic hepatitis indistinguishable from early liver cirrhosis in A. We retrospectively evaluated the efficacy of albumin-bilirubin (ALBI) grade, which been proposed as a new for hepatic function, grading hepatocellular carcinoma (HCC) patients based on function and predicting their prognosis.From 2000 to 2014, 2584 naïve HCC [69.0 ± 9.8 years old, 1850 men, 734 female, class A:B:C = 1871:558:155] were enrolled. TNM staging...
Background/aim Sarcopenia is recognized as a condition related to quality of life and prognosis in patients with chronic liver disease, although no useful strategy for improving muscle volume strength has been established. Here, we evaluated the efficacy supplementation branched-chain amino acid (BCAA) administration walking exercise. Patients methods From December 2015 July 2016, 33 Japanese outpatients cirrhosis were enrolled (median: 67 years, HCV : HBV alcohol others=26 2 3, male...
Objective Bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) is a frequent adverse event ESD. We aimed to develop and externally validate clinically useful prediction model (BEST-J score: ESD Trend from Japan) bleeding EGC. Design This retrospective study enrolled patients who underwent Patients in the derivation cohort (n=8291) were recruited 25 institutions, external validation (n=2029) eight institutions other areas. In cohort, weighted points assigned...
Endoscopic resection (ER) is widely used as a minimally invasive therapy to remove superficial non-ampullary duodenal tumor (SNADT). However, the indication criteria have not yet been clearly determined. At our institute, ER done only for SNADT measuring ≤ 20 mm. We report findings on therapeutic outcomes of SNADT.We carried out in 47 patients with SNADT. Indication included lesion suspected high-grade dysplasia or mucosal cancer and The methods carry en bloc were endoscopic (EMR: 17...
To elucidate the clinical significance of muscle wasting in regard to survival hepatocellular carcinoma (HCC) patients undergoing sorafenib treatment, we evaluated prognostic factors including at start treatment.We enrolled 93 with unresectable HCC (68.3 ± 9.4 years old, 81 men, 12 women, Child-Pugh score 5:6:7 = 69:22:2) who were treated sorafenib. Muscle was based on psoas area index (psoas level middle third lumbar vertebra [cm2 ] / height [m]2 ) calculated from computed tomography...
Abstract Background The incidence of proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) has been increasing. While surgical intervention with Laparoscopic Nissen Fundoplication remains the gold standard, less invasive anti-reflux interventions are desired. We have developed a minimally mucosal ablation (ARMA) treatment. Herein, we report its technical details and describe feasibility, safety, efficacy in PPI-refractory GERD. Methods conducted prospective...
The frequency of sarcopenia, defined as loss both muscle volume and strength, was analyzed in chronic liver disease (CLD).From April to September 2015, 807 Japanese CLD patients treated outpatients were enrolled (67.1±10.0 years, men : women=466 341, hepatitis C virus B alcohol other=511 134 3 45 114). Sarcopenia diagnosed when the patient showed reduced handgrip whereas those with only classified 'v-presarcopenia' strength 's-presarcopenia'. Muscle determined using computed tomography...
Background and Aim Anticoagulants are used to prevent thromboembolic events. Direct oral anticoagulants ( DOAC ) our new choice; however, their effect on bleeding risk for endoscopic treatment has not been reported. We aimed assess the clinical of compared warfarin gastric submucosal dissection ESD ). Methods retrospectively studied 97 patients treated 108 neoplasms with in three referral institutes. Twenty‐four were taking , including dabigatran (12), rivaroxaban (11), apixaban (one) 73...
Abstract Background and Aim To develop a scoring method using with common clinical data for predicting hepatocellular carcinoma (HCC) development after sustained virological response at 24 weeks (SVR24) treatment direct acting antivirals (DAAs), we retrospectively evaluated features of patients who obtained SVR24. Methods From October 2014 to December 2017, 1069 hepatitis C virus without past history HCC, SVR24 by DAAs two different areas, were enrolled (the training [ n = 484,...
Allergic diseases and ulcerative colitis (UC) share pathophysiological similarities. This study aimed to investigate the unclear association between allergic mucosal healing (MH), an important factor in prognosis of UC. We studied 289 Japanese patients with Information on (bronchial asthma, atopic dermatitis, pollen allergy, food drug allergy), as diagnosed by physicians, was collected through self-reported questionnaires. The definition MH Mayo Endoscopic Score 0. each disease its...
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Abstract Background Muscle atrophy (MA) and muscle strength decline are important clinical features in chronic liver disease (CLD) patients. An easy to perform MA screening method without need for special equipment would be helpful. We evaluated the usefulness of previously reported finger‐circle test as CLD Methods retrospectively enrolled 358 Japanese outpatients (70.8 ± 10.2 years, male/female = 234/124) who had undergone a computed tomography examination from December 2017 March 2018,...
We investigated the factors associated with synchronous multiple early gastric cancers and determined their localization.
<b><i>Background/Aim:</i></b> Determination of failure transarterial chemoembolization (TACE) for treatment Barcelona Clinic Liver Cancer stage B (BCLC-B) hepatocellular carcinoma (HCC) has become important because the development tyrosine kinase inhibitor (TKI) treatment. We evaluated usefulness and efficacy newly proposed time to TACE progression (TTTP). <b><i>Patients Methods:</i></b> From 2006 2016, 192 BCLC-B HCC patients [median age 72...
A simple serum biomarker for clinical outcome in patients with ulcerative colitis (UC) remains an unmet need. Some studies have shown association between C-reactive protein (CRP)-albumin ratio (CAR) and prognosis inflammatory bowel disease (IBD), but evidence regarding the CAR UC limited. We evaluated Japanese UC.Subjects were 273 UC. Clinical remission was defined as absence of both abnormally high stool frequency (< 3 per day) rectal bleeding. Mucosal healing (MH) Mayo endoscopic subscore...
This study investigated the prognostic impact of muscle volume loss (MVL) and function decline in patients undergoing resection for hepatocellular carcinoma (HCC).This enrolled 171 naïve HCC treated with from 2007 to 2015, after excluding those lacking spirometry or computed tomography findings, who had received non-curative treatments, restrictive obstructive lung disorders. The median peak expiratory flow rate (%PEF) was set as cut-off value decline, MVL diagnosed using a previously...
We examined the prognosis of liver cirrhosis (LC) patients with and without portal hypertension (PHT) muscle volume loss (MVL).From 2006 to 2016, 346 LC outpatients (PHT/non-PHT = 173/173) were enrolled (median age, 69 years; men / women, 204/142; Child-Pugh A B, 230/116; presence MVL 15.6% in each group) after propensity matching, following exclusion those hepatocellular carcinoma (HCC) beyond Milan criteria C. Portal was defined as positive for significant esophagogastric varices;...
Objective Serum albumin is used as a marker of acute inflammation. Several studies have addressed the association between serum and clinical outcome in patients with ulcerative colitis (UC). While mucosal healing (MH) has been indicated therapeutic goal for UC, MH remains unclear. We evaluated this issue UC overall explored whether duration affected association. Design This cross-sectional study recruited consecutive UC. Study subjects consisted 273 Japanese was divided into tertiles based...
As the aging of people in a society advances, number elderly patients older than 80 years Japan with gastric cancer continues to increase. Although delayed ulcer bleeding is major adverse event after endoscopic submucosal dissection (ESD), little known about characteristic risk factors for undergoing ESD. This study aimed evaluate ESD years.We retrospectively evaluated incidence 10,320 early-stage resected by between November 2013 and January 2016 at 33 Japanese institutions investigated...