A5038487642- Fire dynamics and safety research
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Liver Disease Diagnosis and Treatment
- Vestibular and auditory disorders
- RNA Research and Splicing
- Evacuation and Crowd Dynamics
- RNA modifications and cancer
- Ear Surgery and Otitis Media
- Ophthalmology and Eye Disorders
- Virtual Reality Applications and Impacts
- Carbohydrate Chemistry and Synthesis
- Glaucoma and retinal disorders
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Ear and Head Tumors
- Glycosylation and Glycoproteins Research
- Coal Properties and Utilization
- Spinal Fractures and Fixation Techniques
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
Toho University
2023-2025
Kindai University
1993-2025
Osaka University
1993-2024
The University of Texas Health Science Center at San Antonio
2017-2024
Nippon Paper Industries (Japan)
2021-2024
Kyushu Dental University
2023-2024
The University of Texas at San Antonio
2018-2024
The University of Texas Health Science Center at Houston
2024
Hiroshima University
2022
Izumi City General Hospital
2009-2022
Agelasphin-9b, (2S,3S,4R)-1-O-(alpha-D-galactopyranosyl)-16-methyl-2- [N-((R)-2- hydroxytetracosanoyl)-amino]- 1,3,4-heptadecanetriol, is a potent antitumor agent isolated from the marine sponge Agelas mauritianus. Various analogues of agelasphin-9b (a lead compound) were synthesized, and relationship between their structures biological activities was examined using several assay systems. From results, KRN7000, (2S,3S,4R)-1-O-(alpha-D-...
A glucocorticoid, dexamethasone, inhibited the production of a leukocyte chemotactic cytokine, interleukin 8 (IL-8), as well mRNA expression by glioblastoma cell line, T98G, stimulated with 1 (IL-1). Dexamethasone also IL-8 promoter-driven chloramphenicol acetyltransferase (CAT) activities induced IL-1, suggesting that dexamethasone mainly at transcriptional level. Moreover, CAT assay revealed nuclear factor-kappa B (NF-kappa B) binding site was crucial cis-element required for conferring...
Although transcatheter arterial chemoembolization (TACE) is the standard of care for intermediate-stage hepatocellular carcinoma (HCC), this a largely heterogeneous disease that includes subgroup patients who do not benefit from TACE. The treatment strategy currently remains an unmet need in clinical practice. Here, we performed proof-of-concept study lenvatinib may be more favorable option over TACE as initial HCC with large or multinodular tumours exceeding up-to-seven criteria. This...
mRNA translation plays a central role in the regulation of gene expression and represents most energy consuming process mammalian cells. Accordingly, dysregulation is considered to play major variety pathological states including cancer. Ribosomes also host chaperones, which facilitate folding nascent polypeptides, thereby modulating function stability newly synthesized polypeptides. In addition, emerging data indicate that ribosomes serve as platform for repertoire signaling molecules, are...
The diversity of MTOR-regulated mRNA translation remains unresolved. Whereas ribosome-profiling suggested that MTOR almost exclusively stimulates the TOP (terminal oligopyrimidine motif) and TOP-like mRNAs, polysome-profiling indicated also modulates mRNAs without 5′ motif (non-TOP mRNAs). We demonstrate in studies, detection MTOR-dependent changes non-TOP was obscured by low sensitivity methodology biases. Transcription start site profiling using nano-cap analysis gene expression (nanoCAGE)...
Atezolizumab plus bevacizumab therapy is extremely effective in the treatment of intermediate-stage hepatocellular carcinoma (HCC), with a response rate 44%, as reported IMbrave150 trial. When tumor shrinkage obtained, achieving complete (CR) possible many cases using curative conversion resection, ablation, or superselective transarterial chemoembolization (TACE) intent. This concept, i.e., by combining systemic and locoregional therapy, has not been before. multicenter proof-of-concept...
Metformin has been reported to lower cancer incidence among type II diabetics. exhibits antiproliferative and antineoplastic effects associated with inhibition of mammalian target rapamycin complex 1 (mTORC1), but the mechanisms are poorly understood. We provide a unique genome-wide analysis translational targets canonical mTOR inhibitors (rapamycin PP242) compared metformin, revealing that metformin controls gene expression at level mRNA translation an extent comparable inhibitors....
The binding of the eukaryotic initiation factor 4E (eIF4E) to mRNA 5' cap structure is a rate-limiting step in translation initiation. eIF4E promotes ribosome recruitment mRNA. In Drosophila, homologous protein (d4EHP) forms complex with partners suppress distinct mRNAs by competing for structure. This repression mechanism essential asymmetric distribution proteins and normal embryonic development Drosophila. contrast, physiological role mammalian 4EHP (m4EHP) was not known. this study, we...
Abstract Active-site mTOR inhibitors (asTORi) hold great promise for targeting dysregulated signaling in cancer. Because of the multifaceted nature mTORC1 signaling, identification reliable biomarkers sensitivity tumors to asTORi is imperative their clinical implementation. Here, we show that cancer cells acquire resistance by downregulating eukaryotic translation initiation factor (eIF4E)-binding proteins (4E-BPs—EIF4EBP1, EIF4EBP2). Loss 4E-BPs or overexpression eIF4E renders neoplastic...
Background: This study investigated the impact of baseline liver function according to Child–Pugh score and ALBI (albumin-bilirubin) grade on outcomes patients with unresectable hepatocellular carcinoma treated lenvatinib. Methods: A total 82 lenvatinib were included. The correlations treatment outcomes, including objective response rate per mRECIST (modified Response Evaluation Criteria in Solid Tumor), time failure, duration, likelihood discontinuation due adverse events, assessed Patients...
MicroRNAs (miRNAs) play critical roles in a variety of biological processes through widespread effects on protein synthesis. Upon association with the miRNA-induced silencing complex (miRISC), miRNAs repress target mRNA translation and accelerate decay. Degradation is initiated by shortening poly(A) tail CCR4-NOT deadenylase followed removal 5' cap structure exonucleolytic decay mRNA. Here, we report direct interaction between large scaffolding subunit CCR4-NOT, CNOT1, translational...
Abstract Ternary complex (TC) and eIF4F assembly are the two major rate-limiting steps in translation initiation regulated by eIF2α phosphorylation mTOR/4E-BP pathway, respectively. How TC coordinated, however, remains largely unknown. We show that mTOR suppresses of mRNAs activated under short-term stress wherein recycling is attenuated phosphorylation. During acute nutrient or growth factor stimulation, mTORC1 induces eIF2β recruitment NCK1 to eIF2, decreases bolsters recycling....