A5078537732- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Colorectal Cancer Screening and Detection
- TGF-β signaling in diseases
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Spinal Fractures and Fixation Techniques
- Liver Disease Diagnosis and Treatment
- Nutrition and Health in Aging
- Anorectal Disease Treatments and Outcomes
- Spine and Intervertebral Disc Pathology
- Cancer Cells and Metastasis
- Neuroendocrine Tumor Research Advances
- Kruppel-like factors research
- Genetic factors in colorectal cancer
- Cancer Research and Treatments
- Frailty in Older Adults
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Stoma care and complications
- Medical Imaging and Analysis
- Tissue Engineering and Regenerative Medicine
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
The University of Tokyo
2013-2025
Technical Data Analysis (United States)
2023
Association of Research Libraries
2023
Intellectual Ventures (United States)
2023
University of Tokyo Hospital
2023
Tokuyama (Japan)
2018-2022
Shimane University
2021
Doai Memorial Hospital
2020
Japan Organization of Occupational Health and Safety
2020
Mochida Pharmaceutical (Japan)
2019
Zinc finger E-box binding protein 1 (ZEB1) and ZEB2 induce epithelial-mesenchymal transition (EMT) enhance cancer progression. However, the global view of transcriptional regulation by ZEB1 is yet to be elucidated. Here, we identified a ZEB1-regulated inflammatory phenotype in breast cells using chromatin immunoprecipitation sequencing RNA sequencing, followed gene set enrichment analysis (GSEA) ZEB1-bound genes. Knockdown and/or resulted downregulation genes encoding cytokines related poor...
To identify proteins that could be molecular targets for diagnosis and treatment of hepatitis C virus-related hepatocellular carcinoma (HCV-related HCC), we used a proteomic approach to analyze protein expression in samples human liver. Twenty-six pairs tumorous corresponding nontumorous liver from patients with HCV-related HCC six normal were analyzed by two-dimensional gel electrophoresis liquid chromatography-tandem mass spectrometry. One the numerous spots showed stronger intensity than...
Abstract Poor prognoses for colorectal cancer patients with metastatic lesions have driven demand the development of novel targeted therapies. Here, we demonstrate that expression bone morphogenetic protein 4 (BMP-4) is universally upregulated in human cells and tissues, resulting activated BMP signaling. Inhibition endogenous signaling by type I receptor inhibitor LDN-193189 elevated phosphatase DUSP5 cells, inducing apoptosis via dephosphorylation Erk MAPK. Administering to mice diminished...
Abstract Hepatocellular carcinoma (HCC) is a major cause of death in Japan. It has been suggested that hepatitis C virus (HCV) plays an important role hepatocarcinogenesis, because high incidence among the patients. To understand mechanism hepatocarcinogenesis after HCV infection, we performed comparative study on protein profiles between tumorous and nontumorous specimens from patients infected with by means two‐dimensional electrophoresis. Eleven spots were decreased HCC tissues over 50%...
There are limited reports regarding early predictors of objective response (OR) in patients with hepatocellular carcinoma (HCC) treated lenvatinib. This retrospective study including 70 aimed to investigate the efficacy hepatic biochemical markers. Changes tumor marker (alpha-fetoprotein (AFP)/des-gamma-carboxy prothrombin (DCP)) levels and albumin-bilirubin (ALBI) score between baseline value that estimated one month after treatment were evaluated. We identified several OR, changes levels....
140 Background: Surgical removal of metastasized paraaortic lymph nodes (PALNs) can prolong the survival certain patients with colorectal cancer (CRC). However, role postoperative chemotherapy in such remains unknown. Methods: This multi-center retrospective study examined97 PALN metastasis from CRC who underwent surgical resection at 36 centers Japan between 2010 and 2015. Based on adjuvant (AC) after lymphadenectomy, were classified into Non-AC AC groups (27 70 patients, respectively)....
Abstract After endoscopic resection of T1 colorectal cancer (CRC) with a high risk lymph node metastasis (LNM), additional surgery is required. However, the actual frequency LNM based on conventional factors less than 16%. There need for biomarkers to identify CRC carrying avoid unnecessary radical surgery. Based comparison serum miRNA between stage I/II and III from large-scale in silico dataset, we conducted validation analysis selected miRNAs using plasma samples LNM-positive LNM-negative...
Abstract Aim Preoperative chemoradiotherapy (CRT) is administered for locally advanced rectal cancer (LARC); however, its efficacy and toxicity vary among patients. This study aimed to elucidate the relationship between gut microbiota effectiveness adverse events of CRT. Methods prospective included 21 patients with LARC no history antibiotic or probiotic administration 6 months. Tumour mucosa, non‐tumour mucosa faecal samples were collected before after CRT, bacterial DNA was extracted....
Recurrent tumors in colorectal cancer may be removed along with adjacent blood vessels to achieve R0 resection. However, it remains unclear whether aggressively perform this procedure because cause serious intraoperative or postoperative complications. In Case 1, a 62-year-old man underwent radical surgery for rectosigmoid cancer. Three years later, computed tomography scans revealed disseminated nodule near the left external iliac vessels. We resected tumor and that were reconstructed by...
Summary: An ileal conduit is the most commonly used urinary diversion following radical cystectomy. Malignancy of rarely occurs, and Paget disease has not been reported in peristomal skin an conduit. Herein, we describe a case extramammary A 61-year-old male patient had undergone total pelvic exenteration along with ileostomy for colorectal cancer 30 years previously. The presented large ulcer around his right lower abdomen. lesion, including distal end conduit, was excised based on...
<title>Abstract</title> Purpose The role of prophylactic pelvic drains in rectal surgery remains controversial. A significant concern is the risk retrograde drain infection, a type surgical site infection occurring at insertion site. To address limited data on we conducted an analysis to evaluate its features. Methods This retrospective cohort study analyzed 852 consecutive cancer patients who underwent resection with bowel anastomosis and placement single referral hospital Japan between...
Solitary fibrous tumors (SFTs) rarely develop in the pelvis. When they do arise, are usually treated using surgery, although SFTs often very large by time of diagnosis, which makes surgical excision difficult. We report a case 63-year-old man who was referred to our hospital for treatment giant tumor Computed tomography (CT) revealed 30 × 25 19 cm sized hypervascular that almost completely filled pelvic cavity. The diagnosis SFT made CT-assisted needle biopsy. feeding arteries were embolized...
Abstract Background The diagnosis of colitis-associated cancer or dysplasia is important in the treatment ulcerative colitis. Immunohistochemistry p53 along with hematoxylin and eosin (H&E) staining conventionally used to accurately diagnose pathological conditions. However, evaluation immunohistochemistry all biopsied specimens expensive time-consuming for pathologists. In this study, we aimed develop an artificial intelligence program using a deep learning algorithm investigate predict...
Many reports suggest that hepatic steatosis leads to hepatocellular carcinoma (HCC), including hepatitis C virus or non-alcoholic steatohepatitis. Proteomic study of tumor tissues from HCC patients, focusing on apolipoprotein (apo) apoA1, apoB100 and apoE, was performed by immunoblotting. Although the significant changes apoA1 could not be shown statistically, immunoblotting showed increase in protein level apoE 88% patients without gene expression serum level. These results accumulation...
Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme that converts tryptophan to kynurenine. IDO1 expression found not only in tumor cells but also immune and associated with proliferation responses. inhibitors radiation may cooperatively suppress through the alterations Wnt/β-catenin pathway, cell cycle, response. We investigated antitumor effects of combination therapy inhibitor, 1-methyl (1-MT), on colorectal cancer.In vitro experiments were conducted using human murine colon cancer lines...
Purpose. To compare the sagittal alignment of lumbar spine after one-segment posterior interbody fusion (PLIF) using horizontal cylinder (HC) or open box (OB) type cage. Methods. 66 patients underwent instrumented PLIF with bone grafting for lower degenerative disease. HC-type cages were used in 33 men and 13 women aged 20 to 73 (mean, 47) years between September 2001 July 2004. OB-type a 3° lordotic angle 9 11 25 70 53) 2004 2006. Pre- post-operative lordosis intervertebral body angles...