A5053229206- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Peripheral Artery Disease Management
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Blood Pressure and Hypertension Studies
- Infective Endocarditis Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Treatment of Major Depression
- Crop Yield and Soil Fertility
- Rice Cultivation and Yield Improvement
- Tryptophan and brain disorders
- Advanced MRI Techniques and Applications
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
Tokyo Women's Medical University
2016-2025
Taisho Pharmaceutical (Japan)
1999-2024
Tokyo Women's Medical University Hospital
2017-2024
Fukushima Medical University
2024
Kyushu University
2024
The University of Tokyo
2024
Tokyo Medical University
2023
Chiba Prefectural Institute of Public Health
2007-2022
Sakai Chemical Industry (Japan)
2018-2022
National Hospital Organization
2018
Sodium glucose cotransporter 2 (SGLT2) inhibitors have been reported to lower the serum uric acid (SUA) level. To elucidate mechanism responsible for this reduction, SUA and urinary excretion rate of (UE(UA)) were analysed after oral administration luseogliflozin, a SGLT2 inhibitor, healthy subjects. After dosing, decreased, negative correlation was observed between level UE(UA), suggesting that decreased as result increase in UE(UA). The UE(UA) correlated with an D-glucose excretion, but...
Should early surgery be conducted for asymptomatic patients with severe AR an LVEF ≥50% and LVESD index >25 mm/m 2 ?Early may considered .2 C CQ 3 operation very AS preserved LVEF?If the transvalvular peak velocity is ≥5.0 m/s, mean pressure gradient ≥60 mmHg, or AVA ≤0.6 cm , recommended at low surgical risk. B 4Should concomitant tricuspid valve repair mild TR annular dilation (>40 mm 21 in diameter)?Concomitant diameter). 5Can direct oral anticoaglants (DOACs) used AF after bioprosthetic...
The rapid-acting and long-lasting antidepressant effects of (<i>R,S</i>)-ketamine have recently gained much attention. Although (<i>S</i>)-ketamine has been studied as an active isomer, recent evidence suggests that (<i>R</i>)-ketamine exhibits longer-lasting than in rodents. However, the potential not fully addressed. In present study, we compared with those animal models depression, including a model is refractory to current medications. Both exhibited at 30 minutes well 24 hours after...
Abstract Background and Aims The association between periprocedural change in tricuspid regurgitation (TR) outcomes patients undergoing mitral transcatheter edge-to-edge repair (M-TEER) is unclear. This study aimed to examine the prognostic value of TR before after M-TEER. Methods Patients OCEAN-Mitral registry were divided into four groups according baseline post-procedure echocardiographic assessments: no TR/no (no TR), TR/significant (new-onset significant (normalized (residual TR) (all...
To elucidate the effects of intensive LDL-C lowering treatment with a standard dose statin and ezetimibe in patients dyslipidaemia high risk coronary events, targeting less than 70 mg/dL (1.8 mmol/L), compared lipid monotherapy 100 (2.6 mmol/L).The HIJ-PROPER study is prospective, randomized, open-label trial to assess whether standard-dose pitavastatin plus reduces cardiovascular events more acute syndrome (ACS) dyslipidaemia. Patients were randomized (target < [1.8 mmol/L]; ezetimibe) or...
Abstract Aims Loop diuretics are first‐line medications for congestive heart failure (CHF); however, they associated with serious adverse effects, including decreased renal function, and sympathetic nervous renin–angiotensin system activation. We tested whether tolvaptan, a vasopressin V2‐receptor antagonist, could reduce unfavourable furosemide‐induced effects during CHF treatment. Methods results Sixty patients emergently hospitalized owing to CHF‐induced dyspnea were randomly assigned...
Background Limited data are available about clinical outcomes and residual mitral regurgitation (MR) after transcatheter edge-to-edge repair in the large Asian-Pacific cohort. Methods Results From Optimized Catheter Valvular Intervention (OCEAN-Mitral) registry, a total of 2150 patients (primary cause 34.6%) undergoing were analyzed classified into 3 groups according to MR severity at discharge: 0+/1+, 2+, 3+/4+. The mortality heart failure hospitalization rates 1 year 12.3% 15.0%,...
Renal impairment is associated with poor clinical outcomes in patients cardiovascular diseases. Some studies have revealed the impact of renal on who underwent mitral valve transcatheter edge-to-edge repair (M-TEER). However, limited data are available regarding baseline after M-TEER Asian-Pacific heart failure and severe regurgitation. This study sought to examine effect using a large-scale nationwide registry Japan. A total 2,150 enrolled OCEAN-Mitral (Optimized Catheter Valvular...
We report a robust display technology for the screening of disulfide-rich peptides, based on cDNA–protein fusions, by developing novel and versatile puromycin-linker DNA. This linker comprises four major portions: 'ligation site' T4 RNA ligase, 'biotin solid-phase handling, 'reverse transcription primer efficient rapid conversion from an unstable mRNA–protein fusion (mRNA display) to stable mRNA/cDNA–protein (cDNA whose cDNA is covalently linked its encoded protein 'restriction enzyme...
Although clonal hematopoiesis of indeterminate potential (CHIP) is an adverse prognostic factor for atherosclerotic disease, its impact on nonischemic dilated cardiomyopathy (DCM) elusive. The authors performed whole-exome sequencing and deep target among 198 patients with DCM detected germline mutations in cardiomyopathy-related genes somatic CHIP driver genes. Twenty-five were 22 DCM. Ninety-two had pathogenic mutations. Multivariable analysis revealed that was independent risk left...
Abstract 1. Rice (flooded), wheat, maize, soybean, potato, and sugarbeet were grown in fields with without nitrogen application, various traits of the root system quantitatively measured at growth stage when had fully developed.2. The total length whole per unit field area ranged from 21 (potato) to 86 (wheat) km-m−2. surface was only 22 m2-m−2 potato about 90 rice, maize. volume range 1.8 13 (maize) liters -m−2. mean diameter 0.56 mm maize 0.33-0.39 other crops. These values generally...
Background The balance between ischemic and bleeding events their association with platelet reactivity in patients receiving antiplatelet therapy after percutaneous coronary intervention ( PCI ), which differs among regions, is not fully evaluated for East Asians. We examined ischemic/bleeding Japanese undergoing determined associations high/low clinical outcomes. Methods Results PENDULUM (Platelet Reactivity Patients Drug Eluting Stent Balancing Risk of Bleeding Ischemic Event) a...
Transcatheter edge-to-edge repair (TEER) is a less invasive treatment for patients with mitral regurgitation (MR). Limited safety and efficacy data of TEER MitraClip, including the fourth-generation (G4) system, in large cohort, are available.This study aimed to summarize initial experience system MR from registry Japan.The OCEAN (Optimized CathEter vAlvular iNtervention)-Mitral Registry an ongoing, prospective, investigator-initiated, multicenter, observational primary secondary undergoing...
The long-term prognosis of diabetic patients with acute myocardial infarction (AMI) treated by revascularization is uncertain, and the optimal pharmacotherapy for such cases has not been fully evaluated.To elucidate prognostic factors in AMI, a prospective, cohort study involving 3021 consecutive AMI was conducted. All discharged alive from hospital were followed to monitor their every year. primary endpoint all-cause mortality, secondary occurrence major cardiovascular events. To effect...
Background The prognostic impact of optical coherence tomography-diagnosed culprit lesion morphology in acute coronary syndrome (ACS) has not been systematically examined real-world settings. Methods and Results This investigator-initiated, prospective, multicenter, observational study was conducted at 22 Japanese hospitals to identify the prevalence underlying ACS causes (plaque rupture [PR], plaque erosion [PE], calcified nodules [CN]) their on clinical outcomes. Patients with diagnosed...
High bleeding risk (HBR) and acute coronary syndrome (ACS) subtypes are critical in determining cardiovascular event after percutaneous intervention (PCI).