A5005581063- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Cardiac pacing and defibrillation studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Lipoproteins and Cardiovascular Health
- Peripheral Artery Disease Management
- Climate Change and Health Impacts
- Aortic Thrombus and Embolism
- Coronary Artery Anomalies
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Arrest and Resuscitation
- Global Health Care Issues
- Cardiac Fibrosis and Remodeling
- Ion channel regulation and function
- Air Quality and Health Impacts
- Cardiac Ischemia and Reperfusion
- Optical Coherence Tomography Applications
Kawasaki Municipal Hospital
2022-2024
St. Marianna University School of Medicine
2018-2023
Massachusetts General Hospital
2015-2021
Hirosaki University
2011-2020
Harvard University
2016-2020
Hammersmith Hospital
2019
Imperial College London
2019
Institute of Cardiology
2017
Harbin Medical University
2016-2017
Second Affiliated Hospital of Harbin Medical University
2016-2017
Background Plaque erosion is responsible for 25% to 40% of patients with acute coronary syndromes ( ACS ). Recent studies suggest that anti‐thrombotic therapy without stenting may be an option this subset patients. Currently, however, invasive procedure required make a diagnosis plaque erosion. The aim study was identify clinical or laboratory predictors in enable additional procedures. Methods and Results Patients who underwent optical coherence tomography imaging were selected from 11...
Despite the significant decline in cardiovascular mortality women over past several decades, sex differences underlying pathology of acute coronary syndromes remain poorly understood. Previous postmortem studies have demonstrated plaque morphology with a higher prevalence erosion young and more rupture older after menopause, whereas men showed no increase age. However, vivo data are limited.This study included patients who presented syndrome underwent preintervention optical coherence...
Myocardial no reflow after percutaneous coronary intervention (PCI) is associated with poor outcome. Patients ST-segment elevation myocardial infarction (STEMI) caused by plaque rupture are at high risk for reflow. However, specific morphologic characteristics unknown in this population. The aim of study to identify the morphological culprit plaques patients STEMI using both optical coherence tomography (OCT) and intravascular ultrasound (IVUS).We enrolled 145 who underwent OCT IVUS within...
Background— Spotty superficial calcium deposits have been implicated in plaque vulnerability based on previous intravascular imaging studies. Biomechanical models suggest that microcalcifications between 5 and 65 µm diameter can intensify fibrous cap stress, promoting rupture. However, the 100- to 200-µm resolution of ultrasound limits its ability discriminate single from clusters smaller deposits, a optical coherence tomographic investigation evaluated calcifications within long segment...
It is still controversial whether intravenous administration of β-blocker in the very acute phase myocardial infarction (AMI) beneficial. Landiolol an ultra-short-acting that has less effect on blood pressure, but little known about its efficacy and safety for patients with AMI undergoing primary percutaneous coronary intervention (PCI).A consecutive 96 not manifesting cardiogenic shock were prospectively randomized to landiolol (n = 47) or a control group 49). Continuous (3...
There are few reports examining regional differences between rural prefectures and metropolitan areas in the management of acute myocardial infarction (AMI) Japan.Methods Results:In Rural AMI registry, a prospective, multi-prefectural registry 4 (Ishikawa, Aomori, Ehime Mie), total 1,695 consecutive patients were registered 2013. Among them, 1,313 who underwent primary percutaneous coronary intervention (PPCI) within 24 h onset enrolled this study (Rural group), compared with cohort data...
Layered plaques represent signs of previous plaque destabilization. A recent study showed that acute coronary syndrome (ACS) patients with layered culprit have more vulnerability at the lesion and systemic inflammation. We aimed to compare characteristics non-culprit between or without lesion. also evaluated plaques, irrespective phenotype.We studied ACS who had undergone pre-intervention optical coherence tomography (OCT) imaging. The number lesions was on angiogram morphological were by...
Background The prognostic impact of optical coherence tomography-diagnosed culprit lesion morphology in acute coronary syndrome (ACS) has not been systematically examined real-world settings. Methods and Results This investigator-initiated, prospective, multicenter, observational study was conducted at 22 Japanese hospitals to identify the prevalence underlying ACS causes (plaque rupture [PR], plaque erosion [PE], calcified nodules [CN]) their on clinical outcomes. Patients with diagnosed...
We sought to clarify the impacts of premature atrial contractions (PACs) and biochemical markers early after cryoballoon (CB) versus radiofrequency (RF) ablation for fibrillation (AF) on late recurrence AF (LRAF). The study population included 138 patients who underwent first-time paroxysmal with CB (n = 69) or RF 69). compared levels PAC burden Holter monitoring, myocardial-bound creatine kinase (CK-MB), troponin T (TnT), C-reactive protein (CRP) day ablation, we assessed incidence LRAF,...
Recent studies suggest that the presence of calcified nodules (CN) is associated with worse prognosis in patients acute coronary syndrome (ACS). We investigated clinical predictors optical coherence tomography (OCT)-defined CN ACS a prospective multicenter registry.
Background:Wearable cardioverter-defibrillators (WCD) have been available in Japan since April 2014, but their application is still limited.Methods and Results:We report 9 patients with a WCD applied between September 2014. All were at high risk of life-threatening ventricular arrhythmias. During use, 1 patient had sustained tachycardia successful shock delivery; 6 (67%) subsequently underwent implantable cardioverter-defibrillator (ICD) therapy, while 2 no requirement because reduced risk,...
Anomalous origin of the coronary artery (AOCA) with an inter-arterial course (IAC) between great vessels poses a risk for life-threatening cardiovascular event. We assessed, in registry-based study, clinical features, treatment strategies, and prognoses events ensuant to AOCA.Included were 65 AOCA patients (48 men/17 women, aged 41 ± 23 years) from 40 centres who had experienced sudden cardiac arrest (SCA) (n = 30), acute myocardial infarction (AMI) 5), angina 23), or syncope 7). The...
Abstract Weather conditions affect the incidence of acute myocardial infarction (AMI). However, little is known on association weather temperature and humidity with AMI hospitalizations in a super-aging society. This study sought to examine this association. We included 87,911 consecutive patients admitted Japanese acute-care hospitals between April 1, 2012 March 31, 2015. The primary outcome was number per day. Multilevel mixed-effects linear regression models were used estimate average...
Irregular protrusion identified by optical coherence tomography (OCT) immediately following stent implantation has been reported as an independent predictor for adverse cardiac events at one year. However, baseline characteristics the development of irregular are unknown. The aim study was to identify predictors implantation.A total 900 lesions in 786 patients who had post-stent OCT imaging were analysed. divided into two groups: those with (484 lesions, 456 patients) and without (416 330...
Background Seasonal variations in acute coronary syndromes (ACS) have been reported, with incidence and mortality peaking the winter. However, underlying pathophysiology for these remain speculative. Methods Results Patients ACS who underwent optical coherence tomography were recruited from 6 countries. The prevalence of 3 most common pathologies (plaque rupture, plaque erosion, calcified plaque) compared between 4 seasons. In 1113 patients (885 male; mean age, 65.8±11.6 years), rates 50%,...
Background The role of coronary calcification in cardiovascular events and plaque stabilization is still being debated, factors involved the progression are not fully understood. This study aimed to identify predictors for rapid calcification. Methods Results Patients with serial optical coherence tomography imaging at baseline 6 months were selected. Changes index studied. Calcification was defined as product mean arc length. Rapid an increase above median value. Among 187 patients who had...