A5081007779- Physics of Superconductivity and Magnetism
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Superconducting Materials and Applications
- Climate variability and models
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cardiac Imaging and Diagnostics
- Vascular Procedures and Complications
- Peripheral Artery Disease Management
- Meteorological Phenomena and Simulations
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Magnetic properties of thin films
- Liver Disease and Transplantation
- ECG Monitoring and Analysis
- Magnetic Properties and Applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Tropical and Extratropical Cyclones Research
- Ion channel regulation and function
- Kruppel-like factors research
- Venous Thromboembolism Diagnosis and Management
- HER2/EGFR in Cancer Research
Shonan Kamakura General Hospital
2016-2025
Tokyo Women's Medical University
2006-2025
Tokyo Women's Medical University Yachiyo Medical Center
2021-2024
Tsuchiura Kyodo General Hospital
2024
Peptidream (Japan)
2023
International University of Health and Welfare
2016-2023
Sanno Medical Center
2016-2022
Daiichi-Sankyo (Japan)
2019-2022
Daiichi Sankyo (United States)
2022
Shibaura Institute of Technology
2004-2021
Unlike Y123 which forms only a stoichiometric compound, the light rare earth elements (LREs: La, Nd, Sm, Eu, Gd) form solid solution . The presence of such caused depression in superconducting transition temperatures , particularly for La123, Nd123 and Sm123 when they are melt processed air. Recently, we have found that these LRE123 superconductors can greatly be enhanced reduced oxygen atmosphere. Furthermore, values were larger than good quality superconductor high magnetic fields at 77 K....
Using digital IR data obtained by SMS I satellite, the large-scale behavior of convective activity was investigated over tropical Atlantic within GATE area. Spectral analysis has revealed existence two remarkable periodicities which show good association with atmospheric field, namely, a 4-5 day mode and diurnal mode. The area enhanced convection associated moves westward from Africa through Atlantic. Its mean phase speed turned out to be about 7° day-1 wavelength 30° in longitude. vertical...
Abstract The identification of JAK2/MPL mutations in patients with myeloproliferative neoplasms (MPN) has led to the clinical development JAK kinase inhibitors, including ruxolitinib. Ruxolitinib reduces splenomegaly and systemic symptoms myelofibrosis improves overall survival; however, mechanism by which inhibitors achieve efficacy not been delineated. Patients MPN present increased levels circulating proinflammatory cytokines, are mitigated inhibitor therapy. We sought elucidate...
The authors report flux pinning behavior of melt processed YBaCuO containing Y2BaCuO5(211) inclusions. Although the size 211 inclusions is relatively large compared to coherence length, they can work as centers. present mechanism for due normal precipitates. While creep observed in thin films exhibiting high Jc values, rate very small having a magnitude lower which understandable by considering that potential precipitates much larger than centers and thereby motion less affected thermal activation.
Catalytic water oxidation to generate oxygen was achieved using all-inorganic mononuclear ruthenium complexes bearing Keggin-type lacunary heteropolytungstate, [Ru(III)(H(2)O)SiW(11)O(39)](5-) (1) and [Ru(III)(H(2)O)GeW(11)O(39)](5-) (2), as catalysts with (NH(4))(2)[Ce(IV)(NO(3))(6)] (CAN) a one-electron oxidant in water. The atoms of evolved come from confirmed by isotope-labeled experiments. Cyclic voltammetric measurements 1 2 at various pH's indicate that both exhibit three redox...
Using the infrared (IR) irradiance data observed by GMS-1 geostationary satellite, it was tried to quantitize deep convective activity in a manner which is physically more interpretable than conventional areal average. This partly accomplished defining intensity index of clouds within 1° longitude-latitude square mesh takes horizontal variation temperature and vertical distribution atmospheric into account.Diurnal investigated using abovementioned for period during northern hemispheric...
Enzymatic inhibitors of Janus kinase 2 (JAK2) are in clinical development for the treatment myeloproliferative neoplasms (MPNs), B cell acute lymphoblastic leukemia (B-ALL) with rearrangements cytokine receptor subunit receptor–like factor (CRLF2), and other tumors constitutive JAK2 signaling. In this study, we identify G935R, Y931C, E864K mutations within domain that confer resistance across a panel JAK inhibitors, whether present cis V617F (observed MPNs) or R683G B-ALL). do not reduce...
Water oxidation by cerium(IV) ammonium nitrate, CAN, with [IrIII(Cp*)(4,4′-R2-2,2′-bipyridine)(H2O)]2+ (R = OH, OMe, Me or COOH) to evolve oxygen has been investigated together the possible of ligands CAN. The apparent catalytic reactivity is highly dependent on substituent R and highest was obtained when OH. turnover frequency (TOF) catalyticwater CAN [IrIII(Cp*){4,4′-(OH)2-2,2′-bipyridine}(H2O)]2+, which acts as a precatalyst, gradually increased during reaction reach value among Ir...
Although clinically tested JAK inhibitors reduce splenomegaly and systemic symptoms, molecular responses are not observed in most myeloproliferative neoplasm (MPN) patients. We previously demonstrated that MPN cells become persistent to type I bind the active conformation of JAK2. investigated whether CHZ868, a II inhibitor, would demonstrate activity inhibitor cells, murine models, patient samples. JAK2 MPL mutant cell lines were sensitive including cells. CHZ868 showed significant models...
Temporal fluctuations appearing in the summer monsoon over India are investigated by using data of 1962. By method spectrum analysis, it is revealed that two major periodicities exist, at least, temporal fluctuation monsoon. One oscillation around 5 days period and other 15 pericd.The appears mainly range from north Bay Bengal through trough region northern India. The structure disturbance which causes this periodicity examined cross analysis. results show a westward-moving one its...
Abstract Purpose: HER3 is a compelling target for cancer treatment; however, no HER3-targeted therapy currently clinically available. Here, we produced U3-1402, an anti-HER3 antibody–drug conjugate with topoisomerase I inhibitor exatecan derivative (DXd), and systematically investigated its targeted drug delivery potential antitumor activity in preclinical models. Experimental Design: In vitro pharmacologic activities the mechanisms of action U3-1402 were assessed several human cell lines....
In mouse models of lung metastasis, before the appearance significant metastases, localized changes in vascular permeability have been observed, which appear to set stage for tumour growth. However, it is unclear whether this also true human patients. Here, we show that MD-2, a coreceptor Toll-like receptor 4 has key role innate immune response, triggers formation regions hyperpermeability mice by upregulating C-C chemokine type 2 (CCR2) expression. The CCR2-CCL2 system induces abundant...
The pan-phosphoinositide 3-kinase (PI3K) inhibitor BKM120 was found, at high concentrations, to cause cell death in various cellular systems, irrespective of their level PI3K addiction. Transcriptional and biochemical profiling studies were used identify the origin these unexpected apparently PI3K-independent effects. At 5- 10-fold, concentration needed half-maximally inhibit signaling. treatment caused changes expression mitotic genes induction a robust G(2)-M arrest. Tubulin polymerization...
Hepatocellular carcinoma (HCC) is the most common primary malignancy of liver and it third leading cause cancer-related deaths worldwide. Recently, aberrant signaling through FGF19/FGFR4 axis has been implicated in HCC. Here, we describe development FGF401, a highly potent selective, first class, reversible-covalent small-molecule inhibitor kinase activity FGFR4. FGF401 exquisitely selective for FGFR4 versus other FGFR paralogues FGFR1, FGFR2, FGFR3, all kinases kinome. excellent drug-like...
Abstract Trophoblast cell surface antigen 2 (TROP2) is highly expressed on various epithelial tumors and correlates with poor prognosis. We developed the novel TROP2-directed antibody–drug conjugate (ADC), datopotamab deruxtecan (Dato-DXd, DS-1062a), a potent DNA topoisomerase I inhibitor (DXd), evaluated its antitumor activity safety profiles in preclinical models. The pharmacologic mechanism of action Dato-DXd were investigated several human cancer lines xenograft mouse models including...
Angiogenesis and lymphangiogenesis are complex phenomena that involve the interplay of several growth factors receptors. Recently, we have demonstrated in Keratin-14 (K14) promoter-driven Vegf-A transgenic (Tg) mice, not only angiogenesis but also is stimulated. However, mechanism by which VEGFR1 involved remains unclear.To examine how important tyrosine kinase (TK) K14 Tg crossed mice with VEGFR1-TK-deficient to generate double mutant Vegfr1 tk(-/-) mice. exhibit a remarkable decrease...
Biomarkers for patient selection are essential the successful and rapid development of emerging targeted anti-cancer therapeutics. In this study, we report discovery a novel strategy p53–HDM2 inhibitor NVP-CGM097, currently under evaluation in clinical trials. By intersecting high-throughput cell line sensitivity data with genomic data, have identified gene expression signature consisting 13 up-regulated genes that predicts to NVP-CGM097 both lines patient-derived tumor xenograft models....