A5069961447- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Electric and Hybrid Vehicle Technologies
- Fuel Cells and Related Materials
- Acupuncture Treatment Research Studies
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Mesenchymal stem cell research
- DNA Repair Mechanisms
- Healthcare and Venom Research
- Cancer Treatment and Pharmacology
- Metastasis and carcinoma case studies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Breast Cancer Treatment Studies
- Traditional Chinese Medicine Studies
- Breast Implant and Reconstruction
- Advanced Battery Technologies Research
- Diverticular Disease and Complications
- Lipid Membrane Structure and Behavior
- Tracheal and airway disorders
- Intraperitoneal and Appendiceal Malignancies
- Gastrointestinal Tumor Research and Treatment
- Cancer, Lipids, and Metabolism
Saitama Medical University
2010-2024
Noguchi Hospital
2000-2024
Dokkyo Medical University
2014-2023
Sendai City Hospital
2023
Nipro (Japan)
2017-2022
Kanagawa Institute of Technology
2011-2021
Osaka City University
2021
Dokkyo University
2012-2020
Hyogo University
2006-2019
Konan University
2019
Human umbilical cord blood (CB) is a potential source for mesenchymal stem cells (MSC) capable of forming specific tissues, example, bone, cartilage, or muscle. However, difficulty isolating MSC from CB (CB-MSC) has impeded their clinical application. Using more than 450 units donated to two public banks, we found that successful cell recovery fits hyper-exponential function time since birth with very high fidelity. Additionally, significant improvement in the isolation CB-MSC was achieved...
Catalytic water oxidation to generate oxygen was achieved using all-inorganic mononuclear ruthenium complexes bearing Keggin-type lacunary heteropolytungstate, [Ru(III)(H(2)O)SiW(11)O(39)](5-) (1) and [Ru(III)(H(2)O)GeW(11)O(39)](5-) (2), as catalysts with (NH(4))(2)[Ce(IV)(NO(3))(6)] (CAN) a one-electron oxidant in water. The atoms of evolved come from confirmed by isotope-labeled experiments. Cyclic voltammetric measurements 1 2 at various pH's indicate that both exhibit three redox...
MicroRNA-7 (miR-7) has been reported to be a tumor suppressor in all malignancies including colorectal cancer (CRC). However, its significance for CRC clinical outcomes not yet explored. The potential miR-7 act as by coordinately regulating the epidermal growth factor receptor (EGFR) signaling pathway at several levels was examined. We investigated inhibitory effect of CRC, with particular focus on relationship between and EGFR pathway. Quantitative reverse transcription–PCR used evaluate...
Protegrin-1 (PG-1) is a broad-spectrum β-sheet antimicrobial peptide found in porcine leukocytes. The mechanism of action and the orientation PG-1 lipid bilayers are here investigated using 2H, 31P, 13C, 15N solid-state NMR spectroscopy. 2H spectra mechanically aligned chain-perdeuterated 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) indicate that at high concentrations destroys orientational order lamellar bilayer. conformation headgroups unoriented region significantly...
The aim of this work was to study the metabolic fate 4-hydroxy-trans-2-nonenal (HNE) in human plasma, which represents main vascular site reactive carbonyl species (RCS) formation and where pro-atherogenic target proteins are formed. When HNE spiked it rapidly disappeared (within 40 s) no phase I metabolites were detected, suggesting that is due an adduction mechanism. consumption then monitored two plasma fractions: low molecular weight protein fractions (<10 kDa; LMWF) high (>10 HMWF)....
Modeling job: Protonation of a closed seven-coordinate side-on heme peroxide can switch its spin state from high- to low-spin and convert the η2 binding fashion into monodentate configuration afford corresponding hydroperoxide (see scheme). The end-on ferric hydroperoxo–heme species bear covalently appended axial imidazole ligand are easily prepared.
Iodine deficiency in pregnant and lactating women results serious damage to their fetuses, newborns, weaning infants. The effect of dietary iodine intake on maternal infantile thyroid function has not been well studied iodine-sufficient areas, there are few data appropriate gestational age-specific reference ranges for urinary excretion during pregnancy lactation.The aim the study was characterize change Japanese assess effects status mother infant.A total 934 722 newborn infants were...
Background Breast cancer surgery has become less and mutilating, however a mastectomy is required in the case of multicentric, large tumors or recurrences after conservative treatment. The removal nipple areola complex during dramatically increases feeling mutilation. To reduce this negative psychological impact, cancers located outside central area breast, we propose new type nipple-sparing associated with intraoperative electron beam radiotherapy (ELIOT) delivered on region areola....
We demonstrate the generation of symmetrical supercontinuum over 40 nm in 1.55 m region (1540 - 1580 nm) by injecting 1562 nm, 2.2 ps, GHz optical pulses into a 200 m-long, dispersion-flattened polarization-maintaining photonic crystal fiber. The chromatic dispersion and slope fiber at are -0.23 ps/km/nm 0.01 ps/km/nm2, respectively. This is first report band
To verify the relationship between oxidative stress and DNA methylation in young brain, dichlorodiphenyltrichloroethane (DDT) was administered by gavage to male rats at doses of 0, 0.006, 0.06, 0.6, 6, 60 mg/kg/day for a period 4 weeks. The most conspicuous decrease lipid peroxidation level observed 0.06 group compared with controls. Microarray analysis brain samples from control groups revealed that expression 40 genes changed hypothalamus, whereas mRNA unaltered hippocampus. This result...
Introduction: Mesenchymal stromal cells (MSCs) are activated upon inflammation and/or tissue damage and migrate to suppress repair tissues. Migration is the first important step for MSCs become functional; however, migration potency of umbilical cord-derived (UC-MSCs) remains poorly understood. Thus, we aimed assess UC-MSCs in comparison with those bone marrow-derived (BM-MSCs) adipose tissue-derived (AD-MSCs) investigate influence chemotactic factors on these cells. Methods: We compared...
To identify germline E-cadherin mutations responsible for the predisposition to diffuse gastric cancer (DGC) among Japanese, we screened 17 patients with familial aggregation of by sequencing analysis. All were diagnosed DGC and had at least 1 sibling cancer. Two novel gene variants detected. One was detected in patient only associated an amino acid substitution (Val/Met) codon 832 region essential binding beta-catenin. The M832 variant not proband but also 2 other family....
Adenine paired with 8-hydroxyguanine (oh8G), a major component of oxidative DNA damage, is excised by MYH base excision repair protein in human cells. Since activity on an A:G mismatch has also been reported, we compared the His6-tagged proteins, expressed Spodoptera frugiperda Sf21 cells, A:oh8G and mismatches cleavage assay gel mobility shift assay. We ability type 1 mitochondrial 2 nuclear protein, as well polymorphic 1-Q324 2-Q310 proteins 1-H324 2-H310 proteinsby complementation...
Human serum albumin (HSA), the most abundant protein in plasma, has a very unique function, catalyzing conversion of prostaglandin J2 (PGJ2), dehydration product PGD2, to yield Δ12-PGJ2. These PGD2 metabolites are actively transported into cells and accumulated nuclei, where they act as potent inducers cell growth inhibition differentiation, exhibit their own spectrum biological effects. The facts that (i) arachidonic acid bind human (HSA) metabolism these molecules is altered result...
Histologic investigation and analysis of 370 polyps, removed via colonoscope, demonstrated a malignancy rate adenomas about 20 per cent. Even small under 1 cm in diameter were found to have higher malignant potential than previously appreciated. The was with increasing size, females had much males. It is obvious that colonoscopic polypectomy valuable detecting treating early carcinomas the colon.
Copper(II) complexes 1a and 1b, supported by tridentate ligand bpa [bis(2-pyridylmethyl)amine] tetradentate tpa [tris(2-pyridylmethyl)amine], respectively, react with cumene hydroperoxide (CmOOH) in the presence of triethylamine CH3CN to provide corresponding copper(II) cumylperoxo 2a 2b, formation which has been confirmed resonance Raman ESI-MS analyses using 18O-labeled CmOOH. UV-vis ESR spectra as well DFT calculations indicate that a 5-coordinate square-pyramidal structure involving...
Thyroid hormones play crucial roles in the development and functional maintenance of central nervous system. Despite extensive studies neural function thyroid hormones, little is known about effects hypothyroidism on behavioural traits mechanisms underlying such effects. In present study, we report an investigation congenitally hypothyroid mutant rdw rats, revealing a novel The rats were subjected to analyses as rotarod test, open field test circadian activity measurement. To determine cause...