Elizabeth C. Townsend
A5103221584- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Histone Deacetylase Inhibitors Research
- CAR-T cell therapy research
- Cancer-related gene regulation
- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Virus-based gene therapy research
- Cancer Genomics and Diagnostics
- Pharmaceutical studies and practices
- PI3K/AKT/mTOR signaling in cancer
- Chronic Lymphocytic Leukemia Research
- Autophagy in Disease and Therapy
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Chronic Myeloid Leukemia Treatments
Dana-Farber Cancer Institute
2014-2016
Harvard University
2015
University of Michigan
2012-2014
Harvard University Press
2014
AMPK is a master regulator of cellular metabolism that exerts either oncogenic or tumor suppressor activity depending on context. Here, we report the specific agonist GSK621 selectively kills acute myeloid leukemia (AML) cells but spares normal hematopoietic progenitors. This differential sensitivity results from unique synthetic lethal interaction involving concurrent activation and mTORC1. Strikingly, lethality in primary AML cell lines abrogated by chemical genetic ablation mTORC1...
Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is frequently detected in acute myeloid leukemia (AML) patients and associated with a dismal long-term prognosis. FLT3 inhibitors provide short-term disease control, but relapse invariably occurs within months. Pim protein kinases are oncogenic FLT3-ITD targets expressed AML cells. We show that increased expression found samples from treated inhibitors. Ectopic Pim-2 induces resistance to inhibition both FLT3-ITD-induced...
Abstract Our goal is to identify oncogenic loci in regions of recurrent DNA copy number alterations cancer. Constitutional trisomy 21 (Down syndrome) carries a 20-fold increased risk B-ALL, and chr.21 gains are the most common acquired aneuploidy B-ALL. Interstitial amplification chr.21q22 region (iAMP21) also finding B-ALL poor prognosis. However, gene(s) on responsible for this association remain unclear. We studied Ts1Rhr mouse, which germline triplication 31 genes homologous human...
Abstract Translocation of the MLL1 gene, which encodes for histone methyltransferase, MLL1, is found in approximately 10% all cases acute leukemia and generally associated with poor patient outcomes. Recent research has pointed to an essential function wild-type copy these leukemias. In cells, abnormal upregulation MLL1-directed methylation subsequent overexpression gene targets step development progression leukemia. Efficient MLL1-catalyzed can only be achieved when associates complex WDR5,...