Hans Bitter
A5003934063- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Viral-associated cancers and disorders
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Chronic Lymphocytic Leukemia Research
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Asthma and respiratory diseases
- Cell Image Analysis Techniques
- Single-cell and spatial transcriptomics
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Virus-based gene therapy research
- PARP inhibition in cancer therapy
- Immune Cell Function and Interaction
- Biosimilars and Bioanalytical Methods
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Cancer-related Molecular Pathways
Sørlandet Sykehus
2023
Bluebird Bio (United States)
2020-2021
Novartis (United States)
2013-2021
Novartis (Switzerland)
2017
Novartis Institutes for BioMedical Research
2017
La Roche College
2011-2016
Novartis (China)
2016
Sarah Cannon
2015
Université Libre de Bruxelles
2015
Novartis Foundation
2015
To explore the genetic landscape of tumors from patients enrolled on BOLERO-2 trial to identify potential correlations between alterations and efficacy everolimus treatment. The has previously demonstrated that addition exemestane prolonged progression-free survival by more than twofold in with hormone receptor-positive, human epidermal growth factor receptor 2-negative, advanced breast cancer treated nonsteroidal aromatase inhibitors.Next-generation sequencing was used analyze status...
The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms related idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several candidate compounds suggesting that it may be limited value. As an attempt improve the predictive nature this model, integrative bioinformatic approaches were compare molecular alterations in lungs bleomycin-treated mice and patients with IPF. Using gene set enrichment analysis we show first time genes...
Gene therapy with LentiGlobin for sickle cell disease (bb1111, lovotibeglogene autotemcel) consists of autologous transplantation a patient's hematopoietic stem cells transduced the BB305 lentiviral vector that encodes βA-T87Q-globin gene. Acute myeloid leukemia developed in woman approximately 5.5 years after she had received as part initial cohort (Group A) HGB-206 study. An analysis peripheral-blood samples revealed blast contained insertion site. The results an investigation causality...
Blood consists of different cell populations with distinct functions and correspondingly, gene expression profiles. In this study, global miRNA profiling was performed across a panel nine human immune subsets (neutrophils, eosinophils, monocytes, B cells, NK CD4 T CD8 mDCs pDCs) to identify cell-type specific miRNAs. mRNA on the same samples determine if miRNAs certain types down-regulated levels their target genes. Six (miR-143; neutrophil specific, miR-125; cells miR-500; monocyte pDC...
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated cancer characterized by a poor prognosis and high level of lymphocyte infiltrate. Genetic hallmarks NPC are not completely known but include deletion the p16 (CDKN2A) locus mutations in NF-κB pathway components, with relatively low total mutational load. To better understand genetic landscape, integrated genomic analysis was performed using large clinical cohort treatment-naïve tumor specimens. This generally concordant...
Rationale: Emphysema in chronic obstructive pulmonary disease (COPD) can be characterized by high-resolution chest computed tomography (HRCT); however, the repeated use of HRCT is limited because concerns regarding radiation exposure and cost.Objectives: To evaluate biomarkers associated with emphysema COPD-related clinical characteristics, to assess relationships soluble receptor for advanced glycation endproducts (sRAGE), a candidate systemic biomarker identified this study,...
The identification and validation of biomarkers to support the assessment novel therapeutics for COPD continues be an important area research. aim current study was identify systemic protein correlated with measures severity, as well specific signatures associated comorbidities such metabolic syndrome. 142 analytes were measured in serum 140 patients stable COPD, 15 smokers without 30 non-smoking controls. Seven (sRAGE, EN-RAGE, NGAL, Fibrinogen, MPO, TGF-α HB-EGF) showed significant...
The Eastern woodchuck ( Marmota monax ) is naturally infected with hepatitis virus (WHV), a hepadnavirus closely related to the human B (HBV). used as an animal model for studying chronic (CHB) and HBV-associated hepatocellular carcinoma (HCC) in humans, but lack of sequence information has hitherto precluded functional genomics analysis. To address this major limitation model, we report here sequencing, assembly, annotation transcriptome, together generation custom microarrays. Using new...
To gain insight into the molecular regulation of human heart development, a detailed comparison mRNA and miRNA transcriptomes across differentiating human-induced pluripotent stem cell (hiPSC)-derived cardiomyocytes biopsies from fetal, adult, hypertensive hearts was performed. Gene ontology analysis expression levels hiPSCs revealed 3 distinct groups genes: specific, transitional cardiac specification, mature cardiomyocyte specific. Hierarchical clustering data that transcriptome hiPSC...
Biomarkers for patient selection are essential the successful and rapid development of emerging targeted anti-cancer therapeutics. In this study, we report discovery a novel strategy p53–HDM2 inhibitor NVP-CGM097, currently under evaluation in clinical trials. By intersecting high-throughput cell line sensitivity data with genomic data, have identified gene expression signature consisting 13 up-regulated genes that predicts to NVP-CGM097 both lines patient-derived tumor xenograft models....
Smoking and COPD are associated with decreased mucociliary clearance, healthy smokers have shorter cilia in the large airway than nonsmokers. We hypothesized that changes length consistent throughout airway, we further smokers. Because intraflagellar transport (IFT) is process by which of normal produced maintained, alterations IFT lead to short model organisms, also smoking induces expression IFT-related genes epithelium COPD. To assess these hypotheses, was obtained via bronchoscopic...
Even after quitting smoking, the risk of development chronic obstructive pulmonary disease (COPD) and lung cancer remains significantly higher compared to healthy nonsmokers. Based on knowledge that COPD most cancers start in small airway epithelium (SAE), we hypothesized smoking modulates miRNA expression SAE linked pathogenesis smoking-induced disease, some these changes persist cessation. was collected from 10th 12th order bronchi using fiberoptic bronchoscopy. Affymetrix 2.0 arrays were...
Abstract In order to identify biological processes relevant for cell death and survival in the brain following stroke, postischemic transcriptome was studied by a large‐scale cDNA array analysis of three peri‐infarct regions at eight time points during first 24 h reperfusion middle cerebral artery occlusion rat. K ‐means cluster revealed two distinct biphasic gene expression patterns that contained 44 genes (including 18 immediate early genes), involved signaling plasticity (i.e. MAP2K7 ,...
ViralZone (http://viralzone.expasy.org) is a knowledge repository that allows users to learn about viruses including their virion structure, replication cycle and host–virus interactions. The information divided into viral fact sheets describe shape, molecular biology epidemiology for each genus, with links the corresponding annotated proteomes of UniProtKB. Each genus page contains detailed illustrations, text PubMed references. This new update provides linked view through 133 ontology...
<h3>Introduction</h3> Increasing evidence links COPD pathogenesis with pulmonary capillary apoptosis. We previously demonstrated that plasma levels of circulating microparticles released from endothelial cells (EMPs) due to apoptosis are elevated in smokers normal spirometry but low diffusion capacity, is, early lung destruction. hypothesised persists the development and assessed its reversibility healthy following smoking cessation. <h3>Methods</h3> Pulmonary function high-resolution CT...