A5100738930- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Genetic Syndromes and Imprinting
- RNA modifications and cancer
- TGF-β signaling in diseases
- Genomics and Chromatin Dynamics
- Histone Deacetylase Inhibitors Research
- Prenatal Screening and Diagnostics
- Plant Molecular Biology Research
- Congenital heart defects research
- Protein Degradation and Inhibitors
- Plant Reproductive Biology
- Cancer-related molecular mechanisms research
- Pluripotent Stem Cells Research
- Estrogen and related hormone effects
- Renal and related cancers
- Photosynthetic Processes and Mechanisms
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Bone Metabolism and Diseases
- Genetics and Neurodevelopmental Disorders
- Pulmonary Hypertension Research and Treatments
- Neuroendocrine Tumor Research Advances
- Metastasis and carcinoma case studies
- Peroxisome Proliferator-Activated Receptors
Second Affiliated Hospital of Zhengzhou University
2015-2025
Hunan City University
2025
Salk Institute for Biological Studies
2025
Meizhou City People's Hospital
2020-2024
Novartis (China)
2011-2024
Anhui Normal University
2013-2023
Shandong Agricultural University
2013-2023
Henan Provincial People's Hospital
2023
Zhengzhou University
2022
Fujian Medical University
2020
Genomic imprinting is regulated by differential methylation of the paternal and maternal genome. However, it remains unknown how parental established during gametogenesis. In this study, we demonstrate that Dnmt3L, a protein sharing homology with DNA methyltransferases, Dnmt3a Dnmt3b, but lacking enzymatic activity, essential for establishment imprints appropriate expression maternally imprinted genes. We also show Dnmt3L interacts Dnmt3b co-localizes these enzymes in nuclei transfected...
The activin receptor-like kinase 1 (ALK1) is a type I receptor for transforming growth factor-β (TGF-β) family proteins. Expression of ALK1 in blood vessels and mutations the gene human II hereditary hemorrhagic telangiectasia patients suggest that may have an important role during vascular development. To define function development, we inactivated mice by targeting. homozygous embryos die at midgestation, exhibiting severe abnormalities characterized excessive fusion capillary plexes into...
DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b cooperatively regulate cytosine methylation in CpG dinucleotides mammalian genomes, providing an epigenetic basis for gene silencing maintenance of genome integrity. Proper is required the normal growth various somatic cell types, indicating its essential role basic cellular function cells. Previous studies using Dnmt1 −/– or ES cells, however, have shown that undifferentiated embryonic stem (ES) cells can tolerate hypomethylation their...
Ezh2 (Enhancer of zeste homolog 2) protein is the enzymatic component Polycomb repressive complex 2 (PRC2), which represses gene expression by methylating lysine 27 histone H3 (H3K27) and regulates cell proliferation differentiation during embryonic development. Recently, hot-spot mutations were identified in diffused large B-cell lymphomas follicular lymphomas. To investigate if tumor growth dependent on activity Ezh2, we developed a potent selective small molecule inhibitor, EI1, inhibits...
Myostatin is a secreted protein that normally functions as negative regulator of muscle growth. Agents capable blocking the myostatin signaling pathway could have important applications for treating human degenerative diseases well enhancing livestock production. Here we describe potent inhibitor, soluble form activin type IIB receptor (ACVR2B), which can cause dramatic increases in mass (up to 60% 2 weeks) when injected into wild-type mice. Furthermore, show effect attenuated but not...
Parental origin-specific DNA methylation regulates the monoallelic expression of mammalian imprinted genes. The marks or imprints are established in parental germline and maintained throughout embryonic development. However, it is unclear how through extensive demethylation cleavage-stage preimplantation embryos. Previous reports suggested that methyltransferase(s) other than Dnmt1 involved maintenance during cleavage. Here we demonstrate, by using conditional knockout mice, known...
Signal transducer and activator of transcription 3 (STAT3) is a key transcriptional mediator for many cytokines essential normal embryonic development. We have generated unique strain mice with tissue-specific disruption STAT3 in bone marrow cells during hematopoiesis. This specific deletion causes death these within 4–6 weeks after birth Crohn's disease-like pathogenesis both the small large intestine, including segmental inflammatory cell infiltration, ulceration, bowel wall thickening,...
Dot1 is an evolutionarily conserved histone methyltransferase specific for lysine 79 of H3 (H3K79). In Saccharomyces cerevisiae, Dot1-mediated H3K79 methylation associated with telomere silencing, meiotic checkpoint control, and DNA damage response. The biological function in mammals, however, remains poorly understood. Using gene targeting, we generated mice deficient Dot1L, the murine homologue. Dot1L-deficient embryos show multiple developmental abnormalities, including growth impairment,...
Cyclin-dependent kinase 5 (Cdk5) plays a pivotal role in brain development and neuronal migration. Cdk5 is abundant postmitotic, terminally differentiated neurons. The ability of to phosphorylate substrates dependent on activation by its neuronal-specific activators p35 p39. There exist striking differences the phenotypic severity Cdk5-deficient mice p35-deficient mice. Cdk5-null mutants show more severe disruption lamination cerebral cortex, hippocampus, cerebellum. In addition, display...