A5085954427- Immune Cell Function and Interaction
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Sinusitis and nasal conditions
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Ophthalmology and Eye Disorders
- Pharmacological Effects of Natural Compounds
- Immunotherapy and Immune Responses
- Inflammatory mediators and NSAID effects
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Phytochemical Studies and Bioactivities
- Hereditary Neurological Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer Immunotherapy and Biomarkers
- Head and Neck Surgical Oncology
- Genetic and Kidney Cyst Diseases
- Clinical Nutrition and Gastroenterology
- Ocular Diseases and Behçet’s Syndrome
- Head and Neck Anomalies
- Natural Products and Biological Research
- Phytochemistry and Bioactive Compounds
- Nasolacrimal Duct Obstruction Treatments
- IL-33, ST2, and ILC Pathways
First Affiliated Hospital of Dalian Medical University
2021-2025
Dalian Medical University
2021-2025
Chongqing University of Technology
2025
Sun Yat-sen University
2012-2024
The First Affiliated Hospital, Sun Yat-sen University
2017-2024
Nanjing General Hospital of Nanjing Military Command
2023
Anhui University of Traditional Chinese Medicine
2021-2022
Qingdao University of Science and Technology
2021
NYU Langone Health
2020
Kunming Medical University
2011-2019
Foxp3+ regulatory T (Treg) cells and M2 macrophages are associated with increased tumour progression. However, the interaction between Treg remains unclear.The expression of FoxP3 CD163 was detected by immunohistochemistry in 65 cases laryngeal squamous cell carcinoma (LSCC). In vitro, generation activated (aTreg) interactions their precursor were analysed flow cytometry ELISA. vivo, antitumour effects assessed combined targeting aTreg macrophages, intratumoural immunocytes cytometry.In LSCC...
Clinical features and basophil activation levels correlate with serum autoreactivity allergen sensitivity in patients chronic spontaneous urticaria (CSU).To explore the relationship of expression patterns plasma T-helper cell (Th) 1-, Th2-, Th17- Th22-related cytokines CSU.Twenty related were measured analysed 60 CSU, 15 acute urticaria, 10 atopic dermatitis (AD) healthy persons, respectively. Autologous skin testing (ASST) prick (SPT) performed to detect allergy sensitivity, The...
Group 2 innate lymphoid cells (ILC2s) are essential in initiating and driving allergic immune responses. However, there were inconsistent findings of the ILC2 levels rhinitis (AR) patients. This study investigated peripheral blood house dust mite (HDM)-sensitized AR patients their ability to secrete type cytokines. The ILC2s with phenotypic characteristics increased HDM-AR patients' symptom score IL-13 positively associated epithelial cytokine stimulation induced dramatic production IL-5...
MicroRNAs (miRNAs/miRs) in exosomes play crucial roles the onset, progression and metastasis of cancer by regulating stability target mRNAs or inhibiting translation. In present study, differentially expressed miRNAs were identified 27 breast patients 3 healthy controls using RNA sequencing. The microRNAs selected bioinformatic analysis. Subjects followed up for 2 years exosomal miRNA profiles compared between with without recurrence cancer. A total 30 complementary DNA libraries constructed...
Background The epidemiologic profiles of chronic urticaria (CU) vary considerably among regions, and few such data are available from China. Methods We performed a multicenter open questionnaire investigation about the clinical laboratory features CU, defined as recurrent wheals with/without angioedema lasting for ≥6 weeks, 3027 patients. Results Female preponderance was observed (female/male ratio, 1.46 : 1). mean age at diagnosis 34.7 ± 13.8 years, disease duration 18.5 46.1 months (range,...
<title>Abstract</title> <bold>OBJECTIVE: </bold>To investigate the effects of different lifestyle habits on occurrence types colorectal adenomas and their initial stages cancer. <bold>Methods: </bold>276 patients with tubular adenomas, 67 serrated 70 high-grade intraepithelial neoplasia, 194 patients(control group ) underwent colonoscopy were confirmed by pathology in First Affiliated Hospital Dalian Medical University during June 2023-December 2023. Lifestyle habits’ information was...
A new glutathione adduct (M4) was tentatively identified, likely as 2'-hydroxy-3'-(glutathione-S-yl)-monoclofenac, using liquid chromatography-tandem mass spectrometry analysis of incubations diclofenac with human liver microsomes. The same conjugate not detected in either rat or monkey Formation M4 mediated specifically by CYP2C9 microsomes, evidenced the following observations: 1) cDNA-expressed CYP2C9-catalyzing formation M4; 2) inhibition sulfaphenazole, a CYP2C9-selective inhibitor; and...
T regulatory cells (Tregs) contribute to the progression of head and neck squamous cell carcinoma (HNSCC) by suppressing antitumor immunity. However, little is known regarding functional heterogeneity Tregs in HNSCC patients.Using multicolor flow cytometry, frequency three Treg subsets, separated on basis CD45RA Foxp3, from peripheral circulation newly-presenting patients (19 oral cavity carcinoma, 20 hypopharyngeal 18 nasopharyngeal 19 oropharyngeal 36 laryngeal carcinoma) were assessed...
Asthma is a chronic disease involving inflamed airways, which were previously demonstrated, can be modulated by the mesenchymal stem cells derived from induced pluripotent (iPSC-MSCs). However, long-term effects of iPSC-MSCs in airways are still unidentified. This study investigated and potential mechanisms involved immunomodulatory mouse asthma model. Both human bone marrow (BM)-MSCs transplanted into ovalbumin-induced mice before sensitization phase or during challenge phase. Airway...
Background Oral administration of bacterial extracts (eg, Broncho-Vaxom (BV)) has been proposed to attenuate asthma through modulating Treg cells. However, the underlying mechanism not fully characterized. This study sought assess effects oral BV on GSK-3β expression and cells in ovalbumin (OVA)-induced asthmatic mice models. Method Asthmatic models were established with OVA challenge treated BV. Next, infiltration inflammatory including eosinophil neutrophils, mucous metaplasia, levels...
Background Chronic spontaneous urticaria (CSU) is a common skin disorder with etiology that not well understood. Methods In this study, we evaluated the prevalence of autologous serum test (ASST) and prick testing (SPT) to house dust mite (HDM) in 862 CSU cases China. Clinical features, courses treatment responses were also recorded. Results The positive ASST was 46.3%, patients aged 30–39 years had highest rate (52.1%). Positive SPT HDM seen 153 (17.7%) (34.2%) 20 or less. Patients higher...
Introduction: Gualou (Trichosanthes kirilowii Maxim)-Xiebai (Allium macrostemon Bunge) (GLXB) is a well-known herb pair against atherosclerosis (AS). However, the combination mechanisms of GLXB AS remain unclear. Objective: To compare difference in efficacy between and single herbs to explore terms compounds, targets, signaling pathways. Methods: The combined effects were evaluated mice. main compounds identified via quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS) UNIFI...
The underlying causes and factors contributing to the disease severity of chronic spontaneous urticaria (CSU) are unknown.Given important role basophils in pathogenesis that CD63 serves as a useful marker for basophil activation detecting, expression is reliable tool diagnosing allergy hypersensitivity reactions different allergens; objective this study was investigate whether level correlated with allergen sensitization, serum autoreactivity reactivity patients CSU.Basophil-enriched...
Abstract Background Allergen‐specific immunotherapy ( ASIT ) is the main treatment for inducing long‐term immunological and clinical tolerance in patients with IgE‐mediated allergic diseases. Recent open‐label controlled studies on efficacy of atopic dermatitis AD have provided promising results. However, data about possible relationship between improvement symptoms changes serum cytokines are limited. Methods Seventy‐nine moderate to severe sensitized house dust mite HDM were enrolled....
Background: The prevalence of allergic rhinitis (AR) has increased in recent decades. Accumulating evidence indicates that aberrant DNA demethylation modulated by enzymes ten-eleven translocation (TET) promotes an imbalanced immune response. Objective: This study aimed to explore TETs on the activation dendritic cells (DCs) AR. Methods: levels peripheral blood mononuclear (PBMCs), myeloid DCs (mDCs), and plasmacytoid (pDCs) from house dust mite (HDM)-sensitive AR patients healthy volunteers...
Abstract Background Both microbial antigens and allergens are important factors that can trigger atopic dermatitis ( AD ). Monocytes from patients with have been found to express increased sustained levels of high‐affinity IgE receptor (Fcε RI ) Toll‐like 2 TLR 2). We hypothesized putative interactions exist between Fcε on monocytes in the pathogenesis . Objective This study aimed understand whether activation by Pam3 CSK 4 would influence expression , mitogen‐activated protein kinase MAPK...
Tuberculous pleurisy is a kind of tuberculosis, it well known that Th1 lymphocytes play key role in the treatment tuberculosis infection. However, latest studies show Th17 lymphocyte may also an important There close relationship between Treg and Thl7 cells, changes number or function two kinds cells lead to diseases. The current researches on maily focus autoimmune diseases, however, reports about their are limited. In this study, we investigate th17 above cytokines pathogenesis pleurisy;...
Cilia loss and dysfunction is one of the typical pathological features chronic rhinosinusitis with nasal polyps (CRSwNP). Tryptophan-aspartic acid (W-D) repeat containing planar cell polarity effector (WDPCP) has been proven to be an essential element for ciliogenesis in human epithelium, but its role beating cilia remains unclear. In this study, we sought investigate WDPCP underlying mechanism behind polyp tissue. We demonstrated expression epithelium polyps. also investigated MAPK/ERK...
The diagnosis of liver damage induced by mushroom poisoning is still challenging. This study aims to screen the early biological indexes that could predict acute with damage. patients and admitted First Affiliated Hospital Dalian Medical University，China from July 2007 August 2017 were analyzed retrospectively. A total 66 enrolled in this study, 44 22 injury group failure group, respectively. Ten died, a mortality 45.5% group. Multivariable Cox regression showed blood ammonia (NH3) lactic...