A5101906360- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Bone Tissue Engineering Materials
- Mesenchymal stem cell research
- Bone and Dental Protein Studies
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
- Neuroscience and Neural Engineering
- Cellular Mechanics and Interactions
- Pregnancy and preeclampsia studies
- Hippo pathway signaling and YAP/TAZ
- Periodontal Regeneration and Treatments
- MicroRNA in disease regulation
- Folate and B Vitamins Research
- Wnt/β-catenin signaling in development and cancer
- Anesthesia and Neurotoxicity Research
- Genomics, phytochemicals, and oxidative stress
- Circular RNAs in diseases
- Endoplasmic Reticulum Stress and Disease
- Cancer-related gene regulation
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Bone health and treatments
- Cardiac Ischemia and Reperfusion
- Connective tissue disorders research
Chengdu Medical College
2023-2025
Chongqing University of Technology
2025
Nantong Maternity and Child Health Hospital
2016-2024
University of California, Los Angeles
2015-2024
VA Greater Los Angeles Healthcare System
2015-2024
Nantong University
2016-2024
Chengdu Women's and Children's Central Hospital
2024
Creative Commons
2016-2023
China Medical University
2013-2023
First Hospital of China Medical University
2013-2023
Evidence is growing that biological membranes contain lipid microdomains or "rafts" may be involved in processes such as cellular signaling and protein trafficking. In this study, we have used atomic force microscopy to examine the behavior of rafts supported bilayers. We show bilayers composed equimolar dioleoylphosphatidylcholine sphingomyelin spontaneously form rafts, which are detectable raised features. A comparison extents protrusion monolayers indicates two leaflets bilayer coincide....
The origin of sinoatrial node (SAN) pacemaker activity in the heart is controversial. leading candidates are diastolic depolarization by "funny" current (If) through HCN4 channels (the "Membrane Clock" hypothesis), cardiac Na-Ca exchange (NCX1) response to intracellular Ca cycling "Calcium and a combination two ("Coupled Clock"). To address this controversy, we used Cre/loxP technology generate atrial-specific NCX1 KO mice. protein was undetectable atrial tissue, including SAN. Surface ECG...
Engineering the osteochondral junction requires fabrication of a microenvironment that supports both osteogenesis and chondrogenesis. Multiphasic scaffold strategies utilizing combination soluble factors extracellular matrix components are ideally suited for such applications. In this work, contribution an osteogenic nanoparticulate mineralized glycosaminoglycan (MC‐GAG) dually chondrogenic growth factor, BMP‐9, in differentiation primary human mesenchymal stem cells (hMSCs) is evaluated....
Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen.
Introduction: Osseous defects of the craniofacial skeleton occur frequently in congenital, posttraumatic, and postoncologic deformities. The field scaffold-based bone engineering emerged to address limitations using autologous for reconstruction such circumstances. In this work, authors evaluate 2 modifications three-dimensional collagen-glycosaminoglycan scaffolds an effort optimize structural integrity osteogenic induction. Methods: Human mesenchymal stem cells (hMSCs) were cultured media...
Ischemic preconditioning has been reported to protect against spinal cord ischemia-reperfusion (I-R) injury, but the underlying mechanisms are not fully understood. To investigate this, Japanese white rabbits underwent I-R (30 min aortic occlusion followed by reperfusion), ischemic (three cycles of 5 plus reperfusion) I-R, or sham surgery. At 4 and 24 h following reperfusion, neurological function was assessed using Tarlov scores, blood barrier permeability measured Evan’s Blue...
Abstract RNA silencing is a conserved mechanism in eukaryotic organisms to regulate gene expression. Argonaute (AGO), Dicer-like (DCL) and RNA-dependent polymerase (RDR) proteins are critical components of silencing, but how these families’ functions sugarcane were largely unknown. Most stress-resistance genes modern cultivars ( Saccharum spp.) originated from wild species , for example S. spontaneum . Here, we used genome-wide analysis phylogenetic approach identify four DCL 21 AGO 11 RDR...
Abstract The ability of the extracellular matrix (ECM) to instruct progenitor cell differentiation has generated excitement for development materials‐based regenerative solutions. Described a nanoparticulate mineralized collagen glycosaminoglycan (MC‐GAG) material capable inducing in vivo skull regeneration without exogenous growth factors or ex cell‐priming is described previously. Here, contribution titrating stiffness osteogenicity evaluated by comparing noncrosslinked (NX‐MC) and...
Collagen type I alpha 1 chain (COL1A1) is a key protein encoding fibrillar collagen, playing crucial role in the tumor microenvironment (TME) due to its complex functions and close association with invasiveness. This has made COL1A1 focal point cancer biology research. However, studies investigating relationship between expression levels clinical characteristics of ovarian (OC) remain limited. study integrated resources from publicly available online databases immunohistochemistry (IHC)...
The ability of the extracellular matrix (ECM) to direct cell fate has generated potential for developing a materials-only strategy tissue regeneration. Previously, we described nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) material that efficiently induced osteogenic differentiation human mesenchymal stem cells (hMSCs) and calvarial bone healing without exogenous growth factors or progenitor expansion. In this work, evaluated interactions between MC-GAG primary osteoclasts...
Caveolin-1, a structural protein of caveolae, is cleared unusually slowly from the Golgi apparatus during biosynthetic transport. Furthermore, several caveolin-1 mutant proteins accumulate in apparatus. We examined this behavior further study. accumulation probably resulted loss exit information, not exposure cryptic retention signals, because deletion mutants accumulated Alterations throughout caused accumulation. Thus, most acted indirectly, by affecting overall conformation, rather than...
Abstract The instructive capabilities of extracellular matrix components in progenitor cell differentiation have recently generated significant interest the development bioinspired materials for regenerative applications. Previously, a correlation was described between osteogenic nanoparticulate mineralized collagen glycosaminoglycan scaffolds (MC‐GAG) and an autogenous activation small mothers against decapentaplegic ( Smad1/5) canonical bone morphogenetic protein receptor (BMPR) pathway...
In cardiac-specific Na(+)-Ca(2+) exchanger (NCX) knockout (KO) mice, the ventricular action potential (AP) is shortened. The shortening of AP, as well a decrease L-type Ca(2+) current (I(Ca)), provides critical mechanism for maintenance homeostasis and contractility in absence NCX (Pott C, Philipson KD, Goldhaber JI. Excitation-contraction coupling mice: reduced transsarcolemmal flux. Circ Res 97: 1288-1295, 2005). To investigate that underlies accelerated AP repolarization, we recorded...
It remains challenging to determine the inflammatory activity in Crohn's disease (CD) for lack of specific laboratory markers. Recent studies suggest that serum omentin-1 is associated with response. We aimed assess potential as a marker CD patients.Serum concentrations were determined by enzyme-linked immunosorbent assay (ELISA) patients (n = 240), functional gastrointestinal disorders (FGDs, n 120), and healthy controls (HC, 60) evaluated correlation activity. Expression colonic tissues...