A5070968515- MicroRNA in disease regulation
- Circular RNAs in diseases
- Traditional Chinese Medicine Analysis
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Flavonoids in Medical Research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Liver Disease and Transplantation
- Inflammasome and immune disorders
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Immune Cell Function and Interaction
- Ginseng Biological Effects and Applications
- Phytochemical Studies and Bioactivities
- Natural product bioactivities and synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Phytochemistry and Biological Activities
- Mycobacterium research and diagnosis
- 14-3-3 protein interactions
- Cholesterol and Lipid Metabolism
- Neuroendocrine regulation and behavior
- Biological Activity of Diterpenoids and Biflavonoids
- HER2/EGFR in Cancer Research
- Biomarkers in Disease Mechanisms
Chengdu Medical College
2017-2025
Chengdu Women's and Children's Central Hospital
2017-2025
Maternal and Child Health Hospital of Sichuan Province
2020-2025
Sichuan University
2014-2023
Sichuan Cancer Hospital
2020-2021
University of Electronic Science and Technology of China
2021
Chengdu Third People's Hospital
2020
Cancer Hospital and Research Institute
2020
Abstract Cancer immunotherapy has rapidly transformed cancer treatment, yet resistance remains a significant hurdle, limiting its efficacy in many patients. Circular RNAs (circRNAs), novel class of non-coding RNAs, have emerged as pivotal regulators gene expression and cellular processes. Increasing evidence indicates their involvement modulating to immunotherapy. Notably, certain circRNAs function miRNA sponges or interact with proteins, influencing the immune-related genes, including...
Background: Toll-like receptor 4 (TLR4) is an essential sensor related to tumorigenesis, and overexpression of TLR4 in human tumors often correlates with poor prognosis. Atractylenolide‐I (AT-I), a novel TLR4-antagonizing agent, major bioactive component from Rhizoma Atractylodes Macrocephalae . Emerging evidence suggests that AT-I exerts anti-tumor effects on various cancers such as colorectal cancer, bladder cancer melanoma. Nevertheless, the mammary tumorigenesis remain unclear. Methods:...
Cancer therapeutic resistance remains a significant challenge in the pursuit of effective treatment strategies. Circular RNAs (circRNAs), class non-coding RNAs, have recently emerged as key regulators various biological processes, including cancer progression and drug resistance. This review highlights emerging role circRNAs-mediated autophagy resistance, cellular process that plays dual by promoting both cell survival death. Increasing evidence suggests circRNAs can modulate pathways,...
The pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear due to the complexity its etiology. emerging field epitranscriptome has shown significant promise in advancing understanding and developing new therapeutic approaches. Recent research demonstrated that N4-acetylcytosine (ac4C), an RNA modification within epitranscriptome, is implicated progression various diseases. However, role ac4C MASLD unexplored. Herein, we performed acRIP-ac4c-seq...
Collagen type I alpha 1 chain (COL1A1) is a key protein encoding fibrillar collagen, playing crucial role in the tumor microenvironment (TME) due to its complex functions and close association with invasiveness. This has made COL1A1 focal point cancer biology research. However, studies investigating relationship between expression levels clinical characteristics of ovarian (OC) remain limited. study integrated resources from publicly available online databases immunohistochemistry (IHC)...
BACKGROUND The aim of this study was to investigate the effects Atractylenolide-I (AT-I), a naturally occurring sesquiterpene lactone isolated from Atractylodes macrocephala Koidz, on human ovarian cancer cells. MATERIAL AND METHODS viability and anchorage-independent growth cells were evaluated using MTT colony formation assay, respectively. Cell cycle apoptosis detected with flow cytometry analysis. level cyclin B1 CDK1 measured qPCR ELISA expression Bax, cleaved caspase-9, caspase-3,...
Peroxiredoxins (Prxs) are proposed to function as damage-associated molecular patterns (DAMPs) and contribute post-ischemic neuroinflammation brain injury by activating Toll-like receptor (TLR) 4 at the acute subacute phases after ischemic stroke. However, there few studies concerning inflammatory profiles of six distinct subtypes Prxs (Prx1-Prx6). Our previous study demonstrated that protective effect ligustilide (LIG) against cerebral ischemia was associated with inhibition...
Combination treatment through simultaneous delivery of anticancer drugs and gene with nano-formulation has been demonstrated to be an elegant efficient approach for colorectal cancer therapy. Recently, sorafenib being studied in combination therapy (CRC) attracted attention researchers. On the basis our previous study, pigment epithelium-derived factor (PEDF) loaded nanoparticles showed good effect on CRC vitro vivo. Herein, we designed a (Sora), multi-kinase inhibitor PEDF, powerful...
The incidence of breast cancer is increasing annually, making it a major health threat for women. Chemoprevention using natural, dietary, or synthetic products has emerged as promising approach to address this growing burden. Atractylenolide-III (AT-III), sesquiterpenoid present in various medicinal herbs, demonstrated potential therapeutic effects against several diseases, including tumors, nonalcoholic fatty liver disease, and cerebral ischemic injury. However, its impact on...
Abstract Aims of this study This aims to investigate the potential Huangqin Tang (HQT), a traditional Chinese medicine formulation, in treatment breast cancer (BC) through comprehensive approach integrating network pharmacology, molecular docking, and experimental validation. Methods Chemical composition target information HQT were collected using Traditional Medicine Systems Pharmacology Database Analysis Platform (TCMSP). Disease-related genes obtained from GeneCards database. Network...
Radiotherapy plays a crucial role in the multimodal treatment of breast cancer. However, radioresistance poses significant challenge to its effectiveness, hindering successful cancer therapy. Emerging evidence indicates that Nrf2 and HIF-1[Formula: see text] are critical regulators cellular anti-oxidant responses their overexpression significantly promotes radioresistance. Wogonin (WG), primary component isolated from
// Ting Wang 1, 2, * , Fangyi Long 3, Xiqian Zhang 1 Yujie Yang Xuehua Jiang and Ling Department of Clinical Pharmacy Administration, Key Laboratory Drug Ministry Education, West China School Pharmacy, Sichuan University, Chengdu 610041, Sichuan, 2 Cancer Hospital & Institution, Center, Medicine, University Electronic Science Technology China, 3 Provincial for Women Children, Children's Medical College, These authors have contributed equally to this work Correspondence to: Wang, email:...
In this study, the viability and apoptosis of ovarian cancer cell line OVCAR-3 were assessed using MTT flow cytometry analysis. GFP-tagged LC3 plasmid transfection was utilized to demonstrate occurrence autophagy. The expression HIF-1α, Beclin1, β-actin determined with Western blot We found that hypoxia could inhibit cisplatin induced in cells enhance chemoresistance cisplatin. Furthermore, western used is related HIF-1α-induced All these findings suggest resistance associated