A5101803651- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- RNA Research and Splicing
- Plant nutrient uptake and metabolism
- Head and Neck Cancer Studies
- Plant-Microbe Interactions and Immunity
- Gastric Cancer Management and Outcomes
- Intraperitoneal and Appendiceal Malignancies
- Cancer survivorship and care
- Ferroptosis and cancer prognosis
- Gastrointestinal Tumor Research and Treatment
- Genetics and Plant Breeding
- Epigenetics and DNA Methylation
- Pediatric health and respiratory diseases
- Cytomegalovirus and herpesvirus research
- Legume Nitrogen Fixing Symbiosis
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Animal Virus Infections Studies
- Turfgrass Adaptation and Management
- Viral Infections and Immunology Research
- RNA Interference and Gene Delivery
Chengdu Third People's Hospital
2025
Kunming Medical University
2025
Yan'an Hospital Affiliated To Kunming Medical University
2025
Hunan University of Science and Technology
2024
First Affiliated Hospital of Guangzhou Medical University
2023
State Key Laboratory of Respiratory Disease
2023
Guangzhou Medical University
2023
Renmin Hospital of Wuhan University
2019-2020
Wuhan University
2019-2020
Xian Center for Disease Control and Prevention
2019
The MADS-box genes encode transcription factors with key roles in plant growth and development. A comprehensive analysis of the gene family bread wheat (Triticum aestivum) has not yet been conducted, our understanding their stress is rather limited. Here, we report identification characterization wheat. total 180 classified as 32 Mα, 5 Mγ, Mδ, 138 MIKC types were identified. Evolutionary orthologs among T. urartu, Aegilops tauschii well homeologous sequences three sub-genomes revealed that...
Immune checkpoint inhibitors (ICIs) show optimal treatment effects on recurrent or metastatic nasopharyngeal carcinoma(R/M NPC). Nonetheless, whether sites impact ICIs efficacy remains unclear. We performed a secondary analysis of R/M NPC patients treated with KL-A167, programmed cell death-ligand 1(PD-L1) inhibitor, based multicenter, single-arm, phase II study from China between 2019 and 2021 years, which represents the first most comprehensive effectiveness PD-L1 inhibitor in who have...
The pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear due to the complexity its etiology. emerging field epitranscriptome has shown significant promise in advancing understanding and developing new therapeutic approaches. Recent research demonstrated that N4-acetylcytosine (ac4C), an RNA modification within epitranscriptome, is implicated progression various diseases. However, role ac4C MASLD unexplored. Herein, we performed acRIP-ac4c-seq...
New SARS-CoV-2 variants continue to prevail worldwide, and effective vaccines are needed prevent an epidemic. mRNA gradually being applied the prevention control of infectious diseases with significant safety effectiveness. The spike (S) protein is main target vaccine design, but impact signal peptide (SP), transmembrane region (TM), cytoplasmic tail (CT) on remains unclear. In this study, we constructed three forms related S protein: full-length, deletion TM CT, simultaneous SP, compared...
In patients with gastric cancer (GC), peritoneal metastasis is an indication of the end stage and often indicates a poor outcome. The diagnosis metastasis, especially occult (OPM), remains challenge for surgeons. This study was designed to explore relationship between OPM clinicopathological characteristics preoperative hematological parameters in GC develop nomogram predict probability before surgery.A total 672 from our center were included, including 583 OPM-negative 89 OPM-positive...
Background The global cancer burden is substantial and spiraling. Although rehabilitation specialists could offer assistance, oncologic still underutilized not a routine part of clinical oncology guidelines worldwide. Global investigations disease prevalence years lived with disability (YLDs) for tracheal, bronchus, lung (TBL) are valuable facilitating practice improvement health resource management. objective this study to report the estimates needs TBL cancers from 1990 2019 provide...
Plant domestication via various agricultural practices, e.g., variety selection and fertilizer application, leaded to a narrowed plant genetic diversity in modern cultivars also altered soil ancestral microbiota. It's largely unknown about the effect of changes background and/or fertility on root-associated microbial community assembly. Here, differences bacterial compositions compartments cultivated wild tomato accessions were investigated by 16S rRNA gene sequencing under phosphorus (P)...
Colorectal cancer (CRC) is one of the most common carcinomas with high morbidity and mortality worldwide. However, underlying molecular mechanisms CRC are unclear. The aim present study was to establish role that overexpression LBX2 serves in investigate associated biological pathways. difference expression levels between tissues adjacent normal colorectal assessed using Oncomine database Tumor Immune Estimation Resource. its prognostic significance were analyzed a t‑test χ2 test data from...
<abstract><p>Long non-coding RNA (lncRNA) is considered to be a crucial regulator involved in various human biological processes, including the regulation of tumor immune checkpoint proteins. It has great potential as both cancer biomolecular biomarker and therapeutic target. Nevertheless, conventional experimental techniques are resource-intensive laborious, making it essential develop an accurate efficient computational method facilitate discovery links between lncRNAs...
Objective To analyze the relationship between tumor deposits(TD) and clinicopathological features of locally advanced gastric cancer(LAGC) patients. Methods The characteristics 300 LAGC patients undergoing radical gastrectomy in Renmin Hospital Wuhan University from Jan 2014 to Jul 2017 were collected. The prognosis TD status analyzed retrospectively. Results TD positive 65(21.7%) patients. Univariate analysis showed that depth invasion, lymph node metastasis, pTNM stage, size,...
The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has millions of cases infections, leading to a global health emergency. SARS-CoV-2 spike (S) protein plays the most important role in viral infection, and S1 subunit its receptor-binding domain (RBD) are widely considered attractive vaccine targets. RBD is highly immunogenic linear epitopes for development therapy, but on have rarely been reported. In this study, 151 mouse...
Objective To compare the effect of octreotide combined with omeprazole and alone in treament upper gastrointestinal bleeding.Methods Clinical data 101 patients gastrointesinal bleeding were retrospectively analyzed.According to treatment,the divided into observation group(56 cases) control group(45 cases).The group given omeprazole,and omeprazol alone.Then results two groups analyzed.Results The total effective rate was 91.07％,and higher than that group(73.33％) (x2 =5.61,P ＜0.05) ;The...
Objective To analyze the epidemiological characteristics and etiologic agent of herpangina in Xi’an 2016. Methods Herpangina data random stool samples were collected from two sentinel hospitals. The statistically analyzed with Excel SPSS 18.0 detected enteroviruses genotyped using real-time PCR RT-snPCR. Results Totally 421 cases reported male-to-female ratio was 1.54∶1, age ranged 3 month to 13 years, 90.50% under three years age. Herpangina showed semiannual peaks April...