A5031635511- Electric Power System Optimization
- Power Systems and Renewable Energy
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Power Systems and Technologies
- Smart Grid and Power Systems
- Energy Load and Power Forecasting
- Glycosylation and Glycoproteins Research
- Power System Reliability and Maintenance
- Integrated Energy Systems Optimization
- Optimal Power Flow Distribution
- Nanoparticle-Based Drug Delivery
- Smart Grid Energy Management
- Lipid Membrane Structure and Behavior
- Building Energy and Comfort Optimization
- Recycling and utilization of industrial and municipal waste in materials production
- Plant Pathogens and Fungal Diseases
- Phase Change Materials Research
- Extracellular vesicles in disease
- Lignin and Wood Chemistry
- Vibration and Dynamic Analysis
- Pancreatic function and diabetes
- Advanced Decision-Making Techniques
- Wind Energy Research and Development
- Recycled Aggregate Concrete Performance
Chengdu Third People's Hospital
2021-2025
Southwest Jiaotong University
2023-2025
China Electric Power Research Institute
2012-2024
National Institute of Clean and Low-Carbon Energy
2024
North China Electric Power University
2024
Sichuan University
2016-2023
Chengdu University
2017-2021
University of Science and Technology Beijing
2018-2019
China Electric Equipment Group (China)
2018
Research Institute of Wood Industry
2015-2018
Oral delivery of protein drugs based on nanoparticulate system requires permeation the nanoparticles through mucus layer and subsequent absorption via epithelial cells. However, overcoming these two barriers very different or even contradictory surface properties nanocarriers, which greatly limits oral bioavailability macromolecular drugs. Here we report a simple zwitterions-based nanoparticle (NP) platform, showed great potency in simultaneously both epithelium barriers. The dense...
Nanoparticles (NPs) for oral delivery of peptide/protein drugs are largely limited due to the coexistence intestinal mucus and epithelial barriers. Sequentially overcoming these two barriers is intractable a single nanovehicle requirements different or even contradictory surface properties NPs. To solve this dilemma, mucus-penetrating virus-inspired biomimetic NP with charge reversal ability (P-R8-Pho NPs) was developed by densely coating poly(lactic- co-glycolic acid) NPs cationic...
Although nanoparticles (NPs) have been demonstrated as promising tools for improving oral absorption of biotherapeutics, most them still very limited bioavailability. Lyso-endosomal degradation in epithelial cells is one the important but often-neglected physiological barriers, limiting transport cargoes across intestinal epithelium. We herein reported a solid lipid nanoparticle (SLN) platform with unique feature endosomal escape protein drug delivery. The SLNs consisted solid-lipid shell,...
Protein corona (PC) has been identified to impede the transportation of intravenously injected nanoparticles (NPs) from blood circulation their targeted sites. However, how intestinal PC (IPC) affects delivery orally administered NPs are still needed be elucidated. Here, we found that IPC exerted "positive effect" or "negative depending on different pathological conditions in gastrointestinal tract. We prepared polystyrene (PS) adsorbed with derived tract healthy, diabetic, and colitis rats...
Ligand-modified nanoparticles (NPs) are an effective tool to increase the endocytosis efficiency of drugs, but these functionalized NPs face drawback "easy uptake hard transcytosis" in oral delivery proteins and peptides. Adversely, resulting deficiency transcytosis has not attracted much attention. Herein, modified with low-density lipoprotein receptor (LDLR) ligand NH2-C6-[cMPRLRGC]c-NH2, i.e., peptide-22 (P22NPs) were fabricated investigate strategies related enhancement transcytosis. By...
In oral delivery of biomacromolecules, ligand-modified nanoparticles (NPs) have emerged as a promising tool to improve the epithelial uptake loaded protein/peptide. Unfortunately, stability and transport mechanisms biotherapeutics during intracellular transportation still remained unclear, leading poor transepithelial efficiency. Additionally, developing novel approaches simultaneously monitor payload bioactivity processes is veritably benefit for keeping their bioactivity. present study,...
The pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear due to the complexity its etiology. emerging field epitranscriptome has shown significant promise in advancing understanding and developing new therapeutic approaches. Recent research demonstrated that N4-acetylcytosine (ac4C), an RNA modification within epitranscriptome, is implicated progression various diseases. However, role ac4C MASLD unexplored. Herein, we performed acRIP-ac4c-seq...
Wind power is volatile and uncertain, which makes it difficult to establish an accurate prediction model. How quantitatively describe the distribution of wind output focus this paper. First, assumed that speed a random variable satisfies normal distribution. Secondly, based on nonlinear relationship between power, model established from viewpoint physical mechanism. The proposed successfully shows complex characteristics results show varies significantly with point forecast speed.
In hot climate, phase change material (PCM) can be incorporated into building envelopes to reduce heat gain through the and therefore its cooling demand. this study, energy performance of integrated with PCM has been explored using a popular dynamic simulation package, EnergyPlus, saving mechanism was investigated. The results reflected that could effectively help building's annual consumption by 20.9% for Guangzhou, China. addition, Guangzhou city, 27°C transition temperature, smaller...
Endowing the NPs with specific surface features of dendritic oligopeptides holds great potential for oral delivery peptide/protein drugs.
Intestinal epithelial cells are the primary biological barriers for orally administrated nano-formulations and delivered protein drugs.
Exosome-like nanoparticles (ELNs) have emerged as crucial mediators of intercellular communication, evaluated potential bioactive nutraceutical biomolecules. We hypothesized that oral ELNs some therapeutic effect on irritable bowel syndrome (IBS).
To construct solid lipid nanoparticle (SNPs) drug delivery system loaded with peptide and protein drugs by using mixedsolvents, to study the transcytosis mechanisms of SNPs across intestinal epithelial cells, improve endocytosis efficiency drugs.The formulation insulin-loaded water-in-oil-in-water nanoparticles (INS-SNPs) was prepared a methanol-chloroform mixed solvent. The optimized single factor screening method. INS-SNPs were then characterized in terms their morphology, stability...
In recent years, with the construction of UHV power grid and promotion smart grid, inter-regional energy transactions in China has achieved rapid development, market is becoming more active scale expanding further. With steady improvement supervision system, not only need to meet higher requirements cost control, but also specification operation. addition, considering factors such as mass access clean energy, saving emission reduction, formulation policy needs balance economic benefits,...
This paper investigates a probabilistic assessment method for calculating interregional available transfer capability (ATC) in renewable energy transactions based on randomness and correlation of energy. Firstly, the discrete joint probability model is established to consider wind power speed data multiple farms. Then nonsequential Monte Carlo implemented determine evaluation state numerous uncertainty factors such as load fluctuations, equipment availabilities. As ATC susceptible adjustment...
Rattan Cane Modified with Polyethylene Glycol