A5014244832- Respiratory Support and Mechanisms
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Nanoparticle-Based Drug Delivery
- Cardiac, Anesthesia and Surgical Outcomes
- Airway Management and Intubation Techniques
- Immune Response and Inflammation
- Drug Solubulity and Delivery Systems
- Lipid Membrane Structure and Behavior
- Thyroid Cancer Diagnosis and Treatment
- Anesthesia and Sedative Agents
- Neonatal Respiratory Health Research
- Parathyroid Disorders and Treatments
- Thermal Regulation in Medicine
- Cancer, Stress, Anesthesia, and Immune Response
- Advanced biosensing and bioanalysis techniques
- Tracheal and airway disorders
- Anesthesia and Neurotoxicity Research
- Thyroid and Parathyroid Surgery
- Nosocomial Infections in ICU
- Spinal Cord Injury Research
- Spinal Hematomas and Complications
- Neurosurgical Procedures and Complications
Peking University
2016-2025
Ningxia Medical University
2021-2025
Peking University Third Hospital
2016-2025
Jiangnan University
2025
Jiangxi Provincial Children's Hospital
2025
Southwest University
2024
The University of Sydney
2024
Zhejiang Cancer Hospital
2023-2024
Chinese University of Hong Kong, Shenzhen
2024
Chinese Academy of Sciences
2023-2024
Nanoparticles (NPs) have demonstrated great potential for the oral delivery of protein drugs that very limited bioavailability. Orally administered NPs could be absorbed by epithelial tissue only if they successfully permeate through mucus covers epithelium. However, efficient absorption and permeation require different surface properties a nanocarrier. We herein report self-assembled insulin facilitating both these two processes. The possess nanocomplex core composed cell penetrating...
Objectives: To evaluate the efficacy and safety of short-term low-dose intravenous haloperidol for delirium prevention in critically ill elderly patients after noncardiac surgery. Design: Prospective, randomized, double-blind, placebo-controlled trial two centers. Setting: Intensive care units large tertiary teaching hospitals. Patients: Four hundred fifty-seven 65 yrs or older who were admitted to intensive unit Intervention: Haloperidol (0.5 mg bolus injection followed by continuous...
Oral delivery of protein drugs based on nanoparticulate system requires permeation the nanoparticles through mucus layer and subsequent absorption via epithelial cells. However, overcoming these two barriers very different or even contradictory surface properties nanocarriers, which greatly limits oral bioavailability macromolecular drugs. Here we report a simple zwitterions-based nanoparticle (NP) platform, showed great potency in simultaneously both epithelium barriers. The dense...
Epidemiological studies demonstrate an association between asthma and mental health disorders, although little is known about the shared genetics causality of this association. Thus, we aimed to investigate causal link disorders. We conducted a large-scale genome-wide cross-trait study genetic overlap from UK Biobank eight disorders Psychiatric Genomics Consortium: attention deficit hyperactivity disorder (ADHD), anxiety (ANX), autism spectrum disorder, bipolar eating major depressive (MDD),...
Noninvasive positive pressure ventilation is beneficial for patients with acute respiratory failure. However, its possible benefit lung injury (200 mm Hg < PaO(2)/FIO(2) ≤300 Hg) remains unclear. Our aim was to assess the safety and efficacy of noninvasive compare this high-concentration oxygen therapy.A multicentered randomized controlled trial.Ten multipurpose intensive care units.Forty who fulfilled criteria were included in study.Patients randomly allocated receive either (noninvasive...
Abstract Effective delivery of therapeutic proteins is a formidable challenge. Herein, using unique polymer family with wide‐ranging set cationic and hydrophobic features, we developed novel nanoparticle (NP) platform capable installing protein ligands on the particle surface simultaneously carrying inside by self‐assembly procedure. The loaded (e.g., insulin) within NPs exhibited sustained tunable release, while surface‐coated transferrin) were demonstrated to alter NP cellular behaviors....
The nucleus is the final target of many first‐line chemotherapeutics, but need to overcome multiple physiological barriers imposes conflicting requirements for size and charge on systemically administered drug delivery systems. Here, an N ‐(2‐hydroxypropyl) methacrylamide (HPMA) polymer‐based nanovehicle (PNV) that self‐assembles from anionic HPMA copolymers with charge‐reversal ability cationic intracellularly detachable subgroups (IDS) described. IDS, bearing anticancer nuclear‐homing...
Modifying nanoparticles with targeting peptides which can specifically bind to intestinal epithelium was recently suggested as a strategy further enhance their ability for the oral delivery of macromolecular drugs. However, few studies were focused on comprehensive understanding uptake and transport processes well underlying molecular signaling pathways mediated by ligand modification. In present study, mechanisms cellular tight junction opening associated trimethyl chitosan based (M-NPs)...
Abstract Accumulating evidence suggests that long non‐coding RNA s (lnc s) are playing critical roles in neurogenesis, yet the underlying molecular mechanisms remain largely elusive. Neurite outgrowth is an early step neuronal differentiation and regeneration. Using vitro of neuroblastoma‐derived Neuro‐2a (N2a) cell as a model, we performed expression profiling to identify lnc putatively relevant for neurite outgrowth. We identified Metastasis‐associated lung adenocarcinoma transcript 1...
Although nanoparticles (NPs) have been used for many drug delivery applications, oral absorption of NPs has remained a big challenge. biotherapeutics to penetrate both the diffusion barrier mucus and epithelium. This creates an obstacle developing effective NP platform because overcoming these two barriers requires different or even contradictory surface properties. Inspired by features some viruses, this study reports development unique sub‐50 nm polymeric that possesses large amount...
Abstract Photobiomodulation, by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses cells tissues, has been considered as a possible therapeutic strategy for Alzheimer’s disease (AD), while its specific mechanisms have remained elusive. Here, we demonstrate that cognitive memory impairment an AD mouse model can be ameliorated 1070-nm via reducing cerebral β-amyloid (Aβ) burden, hallmark of AD. The glial cells, including microglia astrocytes,...
This study aimed to investigate the effects of body mass index (BMI) on infertility in women childbearing age.We performed a cross-sectional using data from 3624 participants National Health and Nutrition Examination Survey (NHANES). We used BMI fertility status survey as independent dependent variables, respectively. evaluated their relationship smoothed curve fitting multivariate logistic regression analysis well generalized additive model (GAM) determine effect BMI.Logistic linked after...
Sufficient mucosal permeability is the bottleneck problem in developing an efficient intestinal delivery system of insulin. Cell-penetrating peptide-based nanocomplexes for enhanced permeation insulin were developed this study. Penetratin, a cell-penetrating peptide was site-specifically modified with bis-β-cyclodextrin group. Insulin-loaded prepared by self-assembly using penetratin or its derivative (P-bis-CD). A stronger intermolecular interaction and higher complex stability observed...
Background Early detection of the Acute Respiratory Distress Syndrome (ARDS) has potential to improvethe prognosis critically ill patients admitted intensive care unit (ICU). However, no reliable biomarkers are currently available for accurate early ARDS in with predisposing conditions. Objectives This study examined risk factors and development mortality two prospective cohort studies. Methods We clinical a 178 Beijing, China who were ICU at high ARDS. Identified then replicated second...
Abstract Targeting the specific metabolic phenotypes of colorectal cancer stem cells (CRCSCs) is an innovative therapeutic strategy for (CRC) patients with poor prognosis and relapse. However, context-dependent traits CRCSCs remain poorly elucidated. Here we report that adenylate kinase hCINAP overexpressed in CRC tissues. Depletion inhibits invasion, self-renewal, tumorigenesis chemoresistance a loss mesenchymal signature. Mechanistically, binds to C-terminal domain LDHA, key regulator...