Yongyue Wei
A5081352122- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- COVID-19 epidemiological studies
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related gene regulation
- Heavy Metal Exposure and Toxicity
- Respiratory Support and Mechanisms
- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- SARS-CoV-2 and COVID-19 Research
- Sepsis Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Bioinformatics and Genomic Networks
- COVID-19 Clinical Research Studies
- Lung Cancer Diagnosis and Treatment
- Statistical Methods in Clinical Trials
- Peptidase Inhibition and Analysis
Nanjing Medical University
2016-2025
State Key Laboratory of Reproductive Medicine
2018-2025
Center for Global Health
2018-2025
Peking University
2022-2025
ShanghaiTech University
2025
Union Hospital
2025
Fujian Medical University
2024-2025
He University
2025
Hubei University
2025
Shanghai Maritime University
2025
Ovarian cancer (OV) is the most lethal gynecological in women. We aim to develop a generalized, individualized immune prognostic signature that can stratify and predict overall survival for ovarian cancer.
Background A noninvasive coronary CT angiography (CCTA)–based radiomics technique may facilitate the identification of vulnerable plaques and patients at risk for future adverse events. Purpose To assess whether a CCTA-based radiomic signature (RS) defined with intravascular US was associated increased major cardiac events (MACE). Materials Methods In retrospective study, an RS developed validated using as reference standard. The development data set included first undergoing CCTA then...
Ligands of the endothelial-enriched tunica interna endothelial cell kinase 2 (Tie2) are markedly imbalanced in severe infections associated with vascular leakage, yet regulation receptor itself has been understudied this context. Here, we show that TIE2 gene expression may constitute a novel barrier control mechanism diverse infections. Tie2 declined rapidly wide-ranging models leak-associated infections, including anthrax, influenza, malaria, and sepsis. Forced suppression sufficed to...
The prediction of grain protein function is essential for the advancement food science. Traditional experimental methods are associated with high costs and significant time requirements. Computational recognized their efficiency reduced demands. A new multimodal deep learning method, MMSNet, proposed in this study, data four types grains (japonica, indica, maize, wheat) analyzed. This method fuses structure information predicted by AlphaFold2 combines a multiscale one-dimensional...
The high relapse and mortality rate of small-cell lung cancer (SCLC) fuels the need for epidemiologic study to aid in its prevention.We included 24 studies from ILCCO collaboration. Random-effects panel logistic regression cubic spline were used estimate effects smoking behaviors on SCLC risk explore their non-linearity. Further, we explored whether was mediated through COPD.Significant dose-response relationships observed all quantitative variables. Smoking pack-years associated with a...
Background Early detection of the Acute Respiratory Distress Syndrome (ARDS) has potential to improvethe prognosis critically ill patients admitted intensive care unit (ICU). However, no reliable biomarkers are currently available for accurate early ARDS in with predisposing conditions. Objectives This study examined risk factors and development mortality two prospective cohort studies. Methods We clinical a 178 Beijing, China who were ICU at high ARDS. Identified then replicated second...
In mammals, regenerative therapy after myocardial infarction is hampered by the limited capacity of adult heart, whereas a transient maintained in neonatal heart. Systemic phosphorylation signaling analysis on ischemic myocardium might be helpful to identify key pathways involved heart regeneration. Our aim was define kinase-substrate network and regeneration insult.Quantitative phosphoproteomics profiling performed infarct border zone myocardium, revealed 11 kinases with enriched substrates...
Metabolism of nicotine by cytochrome P450 2A6 (CYP2A6) is a suspected determinant smoking dose and, consequently, lung cancer risk. We conducted genome-wide association study (GWAS) CYP2A6 activity, as measured the urinary ratio trans-3'-hydroxycotinine and its glucuronide conjugate over cotinine (total 3HCOT/COT), among 2,239 smokers in Multiethnic Cohort (MEC) study. identified 248 variants associated with activity (P < 5 × 10
Background: Cardiac hypertrophy is an important prepathology of, and will ultimately lead to, heart failure. However, the mechanisms underlying pathological cardiac remain largely unknown. This study aims to elucidate effects of HINT1 (histidine triad nucleotide–binding protein 1) in Methods: was downregulated human hypertrophic samples compared with nonhypertrophic by mass spectrometry analysis. Hint1 knockout mice were challenged transverse aortic constriction surgery. Cardiac-specific...
World Health Organization (WHO) group 1 pulmonary arterial hypertension (PAH) is a progressive, debilitating disease. Previous observational studies have demonstrated that artery denervation (PADN) reduces pressures in PAH. However, the safety and effectiveness of PADN not been established randomized trial. The aim this study was to determine treatment effects patients with Patients WHO PAH taking PAH-specific drugs for at least 30 days were enrolled multicenter, sham-controlled,...
Differential equations-based epidemic compartmental models and deep neural networks-based artificial intelligence (AI) are powerful tools for analyzing fighting the transmission of COVID-19. However, capability is limited by challenges parameter estimation, while AI fail to discover evolutionary pattern COVID-19 lack explainability. This paper aims provide a novel method (called Epi-DNNs) integrating networks (DNNs) model complex dynamics In proposed Epi-DNNs method, network designed express...
Tobacco smoke is the major environmental risk factor underlying lung carcinogenesis. However, approximately one-tenth smokers develop cancer in their lifetime indicating there significant individual variation susceptibility to cancer. And, reasons for this are largely unknown. In particular, genetic variants discovered genome-wide association studies (GWAS) account only a small fraction of phenotypic variations cancer, and gene-environment interactions thought explain missing disease...
DNA methylation has started a recent revolution in genomics biology by identifying key biomarkers for multiple cancers, including oral squamous cell carcinoma (OSCC), the most common head and neck carcinoma. A multi-stage screening strategy was used to identify DNA-methylation-based signatures OSCC prognosis. We The Cancer Genome Atlas (TCGA) data as training set which were validated two independent datasets from Gene Expression Omnibus (GEO). correlation between corresponding gene...
MicroRNAs (miRNAs) can play important roles in inflammation and infection, which are common manifestations of acute respiratory distress syndrome (ARDS). We assessed if whole blood miRNAs were potential diagnostic biomarkers for human ARDS.This nested case-control study (N = 530) examined a cohort ARDS patients critically ill at-risk controls. Whole miRNA profiles logistic regression analyses identified correlated with ARDS. Stratification analysis also selected markers their role sepsis...