A5100394877- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Pancreatic function and diabetes
- Nanoparticle-Based Drug Delivery
- Pharmacological Effects of Natural Compounds
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Antibiotic Resistance in Bacteria
- Extracellular vesicles in disease
- Diabetes and associated disorders
- Nanocomposite Films for Food Packaging
- Drug-Induced Hepatotoxicity and Protection
- Immunotherapy and Immune Responses
- Metabolism, Diabetes, and Cancer
- Traditional Chinese Medicine Analysis
- Hydrogels: synthesis, properties, applications
- PI3K/AKT/mTOR signaling in cancer
- Cancer Research and Treatments
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- MicroRNA in disease regulation
- Plant-based Medicinal Research
- Metabolomics and Mass Spectrometry Studies
- Antibiotics Pharmacokinetics and Efficacy
- RNA modifications and cancer
Nanjing University of Chinese Medicine
2017-2025
Tulane University
2013-2025
Xi'an University of Technology
2019-2025
University of Electronic Science and Technology of China
2022-2025
Nanchang University
2025
Shanghai University of Traditional Chinese Medicine
2020-2024
Shanghai Traditional Chinese Medicine Hospital
2024
Changhai Hospital
2024
Second Military Medical University
2023-2024
Beijing Luhe Hospital Affiliated to Capital Medical University
2023-2024
Abstract Hydrogels with adhesive properties have potential for numerous biomedical applications. Here, the design of a novel, intrinsically hydrogel and its use in developing internal therapeutic bandages is reported. The involves incorporation “triple hydrogen bonding clusters” (THBCs) as side groups into matrix. THBC through unique “load sharing” effect an increase bond density results strong adhesions to range surfaces, including glass, plastic, wood, poly(tetrafluoroethylene) (PTFE),...
Transplantation of stem cell-derived β (SC-β) cells represents a promising therapy for type 1 diabetes (T1D). However, the delivery, maintenance, and retrieval these remain challenge. Here, we report design safe functional device composed highly porous, durable nanofibrous skin an immunoprotective hydrogel core. The consists electrospun medical-grade thermoplastic silicone-polycarbonate-urethane is soft but tough (~15 megapascal at rupture strain >2). Tuning nanofiber size to less than ~500...
Two Escherichia coli clones (sequence type 648 [ST648] and ST156) that coproduce NDM-5 MCR-1 were detected from a single fowl in China. The blaNDM-5 gene was found on the two indistinguishable IncX3 plasmids different E. isolates, whereas mcr-1 located IncHI2 IncI2 plasmids, respectively, suggesting have spread avian intestinal flora. Also, strains harbor blaTEM-1, blaCTX-M-55, fosA3, aac(6')-Ib multiresistant (especially epidemic clone ST648) might raise potential threat to human health via...
Protein drugs with intracellular targets like Granzyme B (GrB) have demonstrated great proliferative inhibition activity in cancer cells. Their clinical translation, however, relies on the development of safe, efficient, and selective protein-delivery vehicles. Here, we report that epidermal growth factor receptor (EGFR) CD44 dual-targeted multifunctional hyaluronic acid nanogels (EGFR/CD44-NGs) boost protein delivery to ovarian breast cancers vitro vivo. EGFR/CD44-NGs obtained via...
Aberrant protein glycosylation is known to be associated with the development of cancers. The aberrant glycans are produced by combined actions changed enzymes, substrates and transporters in synthesis pathways cancer cells. To identify enzymes aggressive prostate (PCa), we analyzed difference expression glycosyltransferase genes between non-aggressive PCa. Three candidate encoding glycosyltransferases that were elevated PCa subsequently selected. three candidates was then further evaluated...
Breast cancer develops from local tissue but is characterized by a distinct metastatic pattern involving regional lymph nodes and distant organs, which the primary cause of high mortality in breast patients. Herein, optimal docking nanoparticles (NPs) composed laurate-functionalized Pt(IV) prodrug (Pt(lau)), human serum albumin (HSA), lecithin were predicted computational modeling, prepared nanoprecipitation, validated fluorescence spectroscopy. As macrophages have been reported to be...
Protein therapeutics offer a most effective treatment for many human diseases, including diabetes, cardiovascular and malignant tumors. Unlike chemotherapeutics that often cause notorious side effects, protein drugs possess high specificity reduced systemic toxicity. Notably, clinically used are mostly limited to those have extracellular effects. intracellular targets do represent large family of biologics not been introduced into the clinic, because absence translatable delivery vehicles....
N-linked glycoprotein is a highly interesting class of proteins for clinical and biological research. The large-scale characterization glycoproteins accomplished by mass spectrometry-based glycoproteomics has provided valuable insights into the interdependence structure protein function. However, these studies focused mainly on analysis specific sample type, lack integration glycoproteomic data from different tissues, body fluids or cell types. In this study, we collected human...
In situ tumor vaccination is preliminarily pursued to strengthen antitumor immune response. Immunogenic cell death spontaneously releases abundant antigens and adjuvants for activation of dendritic cells, providing a paragon opportunity establishing efficient in vaccination. Herein, Phy@PLGdH nanosheets are constructed by integrating physcion (Phy, an inhibitor the pentose phosphate pathway (PPP)) with layered gadolinium hydroxide (PLGdH) boost radiation-therapy (RT)-induced immunogenic...
Metabolic reprogramming of the tumor microenvironment (TME) and poor immunogenicity are two challenges that cancer immunotherapies have to overcome for improved clinical benefits. Among various immunosuppressive metabolites keep anti-tumor immunity in check, tryptophan catabolite kynurenine (Kyn) is an attractive target blockade given its role mediating immunosuppression through multiple pathways. Here, we present a local chemo-immunometabolic therapy injection supramolecular hydrogel...
Maternal separation in early life has a detrimental effect on the physiological and biochemical functions of brains offspring can lead to anxiety- depression-like behaviors later life. Resveratrol possesses variety pharmacological properties, including anti-inflammatory, anxiolytic, anti-depressive effects. In rodents, resveratrol attenuate induced by chronic unpredictable mild stress, estrogen deficiency, lipopolysaccharide. However, whether administration during adolescence counteract...
Clinically, activated EGFR mutation associated chemo-drugs resistance has severely threaten NSCLC patients. Nanoparticle based small interfering RNA (siRNA) therapy representing another promising alternative by silencing specific gene while still suffered from charge toxicity, strong immunogenicity and poor targetability. Herein, we reported a novel EGFR-mutant relying on edible cation-free kiwi-derived extracellular vesicles (KEVs), which showed sevenfold enhancement of safe dosage compared...
Background: Anti-Calcitonin gene-related peptide monoclonal antibodies (anti-CGRP mAbs) have shown significant efficacy in preventing migraine. However, there been limited reports of adverse events (AEs) after marketing, particularly for eptinezumab launched 2020. The study aimed to mine and analyze the AE signals with four anti-CGRP mAbs from United States Food Drug Administration (FDA) Adverse Event Reporting System (FAERS) database gain insights into safety profile these medications...
Glucokinase is a key regulator of glucose homeostasis, and small molecule allosteric activators this enzyme represent promising opportunity for the treatment type 2 diabetes. Systemically acting glucokinase (liver pancreas) have been reported to be efficacious but in many cases present hypoglycaemia risk due activation at low levels pancreas, leading inappropriately excessive insulin secretion. It was therefore postulated that liver selective activator may offer effective glycemic control...
The efficient intracellular drug delivery is an important challenge due to the slow endocytosis and inefficient release of traditional vehicles such as symmetrical polymer vesicles, which have same coronas on both sides membrane. Presented in this paper a noncytotoxic poly(ethylene oxide)-block-poly(caprolactone)-block-poly(acrylic acid) (PEO113-b-PCL132-b-PAA15) triblock copolymer vesicle with asymmetrical structure. biocompatible exterior PEO are designed for stealthy delivery;...
Inflammatory bowel disease (IBD) such as Crohn's and ulcerative colitis is a chronic autoimmune affecting nearly five million people worldwide. Among all drug delivery system, oral administration the most preferable route for colon-specific targeting treatment of IBD. Herein, an amphiphilic curcumin polymer (PCur) composed hydrophilic poly(ethylene glycol) (PEG) hydrophobic (Cur) linked by disulfide bond was synthesized characterized. The sufficient solubility, nano-scaled size close to...