A5033450333- RNA modifications and cancer
- Axon Guidance and Neuronal Signaling
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Viral gastroenteritis research and epidemiology
- Cancer Genomics and Diagnostics
- Animal Virus Infections Studies
- Muscle Physiology and Disorders
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Phagocytosis and Immune Regulation
- Nanoparticle-Based Drug Delivery
- RNA Research and Splicing
- Fibroblast Growth Factor Research
- Neurobiology and Insect Physiology Research
- Thyroid Cancer Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
- Cellular Mechanics and Interactions
- Developmental Biology and Gene Regulation
- Nerve injury and regeneration
- Cervical Cancer and HPV Research
The University of Texas MD Anderson Cancer Center
2020-2024
Nanjing Medical University
2024
University of California, Davis
2023
UC Davis Comprehensive Cancer Center
2023
Chinese PLA General Hospital
2022
Northeast Forestry University
2022
University Health Network
2018-2021
Princess Margaret Cancer Centre
2017-2021
Tianjin Medical University Cancer Institute and Hospital
2013-2021
National Center for Nanoscience and Technology
2014-2021
During pancreatic tumor development, stellate cells (PSCs) proliferate exuberantly to secrete extracellular matrix (ECM) in the stroma, which presents major barriers for drug delivery and penetration tissue. Thus, down-regulating ECM levels via regulation of PSCs may allow enhanced therapeutic drugs thereby enhancing their efficacy. To regulate PSCs, a metalloproteinase-2 (MMP-2) responsive peptide-hybrid liposome (MRPL) was constructed coassembly tailor-designed MMP-2 amphiphilic peptide...
Background: The aim of this study was to describe the oncologic outcomes patients with BRAFV600E-mutated anaplastic thyroid cancer (ATC) who had neoadjuvant BRAF-directed therapy subsequent surgery. For context, we also reviewed received after surgery, and those did not have surgery therapy. Methods: This a single-center retrospective cohort conducted at tertiary care center in Texas from 2017 2021. Fifty-seven consecutive ATC least 1 month were included. Primary overall survival (OS)...
Abstract Background MicroRNAs (miRNAs) are a large class of tiny non-coding RNAs (~22-24 nt) that regulate diverse biological processes at the posttranscriptional level by controlling mRNA stability or translation. As molecular switch, canonical Wnt/β-catenin signaling pathway should be suppressed during adipogenesis; However, activation this leads to inhibition lipid depots formation. The aim our studies was identify miRNAs might involved in adipogenesis modulating WNT pathway. Here we...
Understanding the dynamics of muscle transcriptome during development and between breeds differing in growth is necessary to uncover complex mechanism underlying development. Herein, we present first transcriptome-wide longissimus dorsi research concerning Lantang (LT, obese) Landrace (LR, lean) pig 10 time-points from 35 days-post-coitus (dpc) 180 days-post-natum (dpn) using Solexa/Illumina's Genome Analyzer. The data demonstrated that myogenesis was almost completed before 77 dpc, but...
Because of the early onset local invasion and distant metastasis, pancreatic ductal adenocarcinoma (PDAC) is most lethal human malignant tumor, with a 5-year survival rate less than 5%. In this study, we investigated role fascin, prometastasis actin-bundling protein, in PDAC progression, invasion, molecular mechanisms underlying fascin overexpression PDAC. Our data showed that expression levels were higher cancer tissues normal tissues, correlated differentiation prognosis. Fascin promoted...
Fibrotic stroma, a critical character of pancreatic tumor microenvironment, provides barrier against the penetration and efficacy various antitumor drugs. Therefore, new strategies are urgently needed to alleviate fibrotic mass increase drug perfusion within cancer tissue. In our current work, we developed β-cyclodextrin (β-CD) modified matrix metalloproteinase-2 (MMP-2) responsive liposome, integrating antifibrosis chemotherapeutic drugs for regulation stellate cells (PSCs), key source...
Porcine reproductive and respiratory syndrome (PRRS) has been one of the most economically important diseases affecting swine industry worldwide causes great economic losses each year. PRRS virus (PRRSV) replicates mainly in porcine alveolar macrophages (PAMs) dendritic cells (DCs) develops persistent infections, antibody-dependent enhancement (ADE), interstitial pneumonia immunosuppression. But molecular mechanisms PRRSV infection still are poorly understood. Here we report on first...
The FOLFIRINOX regimen, a combination of three chemotherapy agents (5‐fluorouracil, irinotecan, oxaliplatin) and folinic acid (a vitamin B derivatives reducing the side effect 5‐fluorouracil), has proved to be effective in treatment pancreatic cancer, is more efficacious than long‐term reference standard, gemcitabine. However, associated with high‐grade toxicity, which markedly limits its clinical application. Encapsulation drugs nanocarriers that selectively target cancer cells promises an...
Tumor-associated macrophages (TAM) play pivotal roles in cancer initiation and progression. Monocytes, the precursors of TAMs, normally undergo spontaneous apoptosis within 2 days, but can subsist inflammatory tumor microenvironment for continuous survival generation sufficient TAMs. The mechanisms underlying tumor-driving monocyte remain obscure. Here we report that cell-derived exosomes were crucial mediators niche. Analysis survival-promoting molecules monocytes revealed activated Ras...
Neutrophil extracellular traps (NETs) promote cancer metastasis in preclinical models following massive exogenous inflammatory stimuli. It remains unknown whether hosts under physiologic conditions experience NETosis and consequent metastasis. Here we show that plasma redox imbalance caused by albumin oxidation promotes inflammation-independent NETosis. Albumin is the major source of free thiol maintains balance. Oxidation albumin-derived sufficient to trigger via accumulation reactive...
PURPOSE Anaplastic thyroid carcinoma (ATC) uniformly present with aggressive disease, but the mutational landscape of tumors varies. We aimed to determine whether tumor mutations affect survival outcomes in ATC. MATERIALS AND METHODS Patients who underwent mutation sequencing using targeted gene panels between 2005 and 2019 at a tertiary referral center were included. Associations status assessed Cox proportional hazards models. RESULTS A total 202 patients included, where 122 died ATC...
There was a large scale outbreak of the highly pathogenic porcine reproductive and respiratory syndrome (PRRS) in China Vietnam during 2006 2007 that resulted unusually high morbidity mortality among pigs all ages. The mechanisms underlying molecular pathogenesis virulent PRRS virus (H-PRRSV) remains unknown. Therefore, relationship between pulmonary gene expression profiles after H-PRRSV infection pathology were analyzed this study using high-throughput deep sequencing...
The aim of study was to discuss the correlation and regulatory mechanism HIF-1 miR-191 expression in pancreatic tumor. association between clinicopathologic characteristics prognosis cancer further explored. After hypoxic cultured for 6 12 h, qRT-PCR Western blot were practiced analyze MIA PaCa-2 Aspac1 cells. We regulated via plasmid siRNA transfection observe alteration expression. ChIP sequencing identified binding sites miR-191. Dual luciferase assays verify sites. Immunohistochemical...
Hypoxia-inducible factor-1α (HIF-1α) is a highly important transcription factor involved in cell metabolism. HIF-1α promotes glycolysis and inhibits of mitochondrial respiration pancreatic ductal adenocarcinoma (PDAC). In response to tumor hypoxia, cyclophilin A (CypA) over-expressed various cancer types, associated with apoptosis, invasion, metastasis, chemoresistance PDAC. this study, we showed that both CypA expression were significantly lymph node metastasis stage. The was correlated...
Stem cell factor (SCF) and hypoxia-inducible factor-1α (HIF-1α) both have important functions in pancreatic ductal adenocarcinoma (PDAC). This study aims to analyze the expression clinicopathological significance of SCF HIF-1α PDAC specimens explore molecular mechanism at cells vitro vivo. We showed that was significantly correlated with via Western blot, PCR, chromatin immunoprecipitation (ChIP) assay, luciferase assay analysis. The level also lymph node metastasis pathological tumor (pTNM)...
Hypoxia is an indicative feature of human neuroblastoma solid tumor. Bioimaging hypoxic cells will be beneficial for tracing and locating the tumor in vivo. In this work, we developed a cell imaging probe based on mechanism transglutaminase 2 (TG2)-catalyzed polymerization fluorescence molecule-labeled peptide monomers intracellular self-assembly polymerized elastin-like polypeptides (ELPs) specifically cells. The key influencing parameters, namely thermosensitivity, molecular weight, upper...