A5056492087- Multiple Myeloma Research and Treatments
- Drug Transport and Resistance Mechanisms
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Cancer therapeutics and mechanisms
- HIV/AIDS drug development and treatment
- Pharmacological Effects and Toxicity Studies
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Hematopoietic Stem Cell Transplantation
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
Moffitt Cancer Center
2012-2025
Clinical Insights
2024
AdventHealth Tampa
2020
Duke University
2014
American Cancer Society
2014
East Tennessee State University
2014
University of South Florida
1998-2012
Molecular Oncology (United States)
2011-2012
University of Wisconsin–Milwaukee
2006
United States Military Academy
2006
PURPOSE Recipients of allogeneic bone marrow transplants (BMTs) who have relapsed may attain complete remissions when treated with transfusions leukocytes obtained from the original donor. We performed a retrospective study to characterize better this new treatment modality. PATIENTS AND METHODS surveyed 25 North American BMT programs regarding their use donor leukocyte infusions (DLI). Detailed forms were used gather data BMT, relapse, DLI, response complications and long-term follow-up...
The B-cell neoplasms, multiple myeloma and non-Hodgkin's lymphoma, frequently become drug resistant, despite initial responses to chemotherapeutic drugs. Tumor cells from eight patients with clinically drug-refractory disease were evaluated by immuno-histochemical staining for monoclonal immunoglobulin (Ig) expression, nuclear proliferation antigen, P-glycoprotein (P-gly) other cellular antigens. P-gly was detected on tumor six of drug-resistant disease. Of the P-gly-positive tumors, five...
P-glycoprotein is a transmembrane protein thought to function as an efflux pump detoxify cells. It associated with multidrug resistance in laboratory systems and has recently been found human tumors vitro clinical drug resistance. We used immunohistochemical method employing two monoclonal antibodies, JSB-1 C-219, detect expression of lymphoma patients. One 42 newly diagnosed untreated patients (2%) seven 11 previously treated drug-resistant (64%) had detectable levels (P less than .001)....
PURPOSE To determine the toxicities and maximum-tolerated dose of cyclosporine (CsA) administered with daunorubicin as a modulator multidrug resistance (MDR) in acute leukemia, to evaluate response treatment its relationship mdr1 gene expression. PATIENTS AND METHODS Patients poor-risk myeloid leukemia (AML) received sequential cytarabine (3 g/m2/d intravenously [i.v.]) days 1 5, (45 mg/m2/d) plus CsA 72-hour continuous infusion (CI) 6 through 8 phase I/II trial. A loading over 2 hours...
Vaults are 13-MDa ribonucleoprotein particles composed largely of a 104-kDa protein, termed major vault protein or MVP, and small RNA, vRNA. While MVP levels have been found to increase up 15-fold in non-P-glycoprotein multidrug-resistant cell lines, the not investigated. As both function mechanism drug resistance cells unknown, we decided determine whether synthesis was coupled MDR. By cloning human gene for vRNA careful quantitation MDR cells, find that is considerable excess MVP....
To compare failure-free survival (FFS) and overall (OS) for patients with metastatic breast cancer treated the gonadotropin-releasing hormone (GN-RH) agonist, goserelin versus surgical ovariectomy.Between August 1, 1987 July 15, 1995 138 (136 eligible) premenopausal estrogen receptor (ER)- and/or progesterone (PgR)-positive were entered by Southwest Oncology Group (SWOG), North Central Cancer Treatment (NCCTG), Eastern Cooperative (ECOG). Prior chemotherapy or therapy disease was not...
Prior studies have shown that the p-glycoprotein is ac cell membrane efflux pump quantitavely increased in expression multidrug-resistant tumor lines. In this study, fresh tissues from patients with multiple myeloma, malignant lymphoma, or metastatic breast cancer were studied immunohistochemically for P-glycoprotein and vitro sensitivity to doxourbicin. Twenty-six who either previously untreated relapse after chemotherapy had specimens submitted could be evaluated both assays. The testing...
The allure of the emerging genomic technologies in cancer is their ability to generate new biomarkers that predict how individual patients will respond various treatments. However, productive implementation into patient care require fundamental changes we consider approvals for indications and track responses. Here briefly describe ongoing efforts identify validate biomarkers, discuss technological hurdles lie ahead, then focus on more pressing political cultural issues that, if left...
Journal Article Systemic Toxic Effects Associated With High-Dose Verapamil Infusion and Chemotherapy Administration Get access Gregory D. Pennock, Pennock Search for other works by this author on: Oxford Academic PubMed Google Scholar William S. Dalton, Dalton * *Correspondence to : MD, PhD, Department of Internal Medicine, University Arizona Cancer Center, College 1515 N Campbell, Tucson, AZ 85724 R. Roeske, Roeske Christopher P. Appleton, Appleton Kurt Mosley, Mosley Patricia Plezia,...
Background. Multiple myeloma is considered to be a drug responsive disease; however, there no cure for this disease and virtually all patients will develop resistance. One form of resistance that has been documented the multidrug phenotype or MDR. Methods. A randomized trial combination vincristine, doxorubicin, dexamethasone (VAD) VAD plus oral verapamil (VAD/v) in refractory multiple was performed by South-western Oncology Group. Verapamil used as chemosensitizing agent attempt overcome...