A5101569378- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Graphene and Nanomaterials Applications
- Platelet Disorders and Treatments
- Peptidase Inhibition and Analysis
- Inflammatory Biomarkers in Disease Prognosis
- Immunotherapy and Immune Responses
- Supramolecular Self-Assembly in Materials
- Pancreatic and Hepatic Oncology Research
- Advanced Nanomaterials in Catalysis
- Protease and Inhibitor Mechanisms
- Lipid Membrane Structure and Behavior
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Cells and Metastasis
- Phagocytosis and Immune Regulation
- Synthesis of β-Lactam Compounds
- Immune cells in cancer
- MicroRNA in disease regulation
- Hernia repair and management
- Dendrimers and Hyperbranched Polymers
- Venous Thromboembolism Diagnosis and Management
University of Chinese Academy of Sciences
2017-2025
Wenzhou Medical University
2010-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2025
National Center for Nanoscience and Technology
2015-2023
Chinese Academy of Sciences
2017-2023
Sino-Danish Centre for Education and Research
2023
Huaibei Normal University
2023
Weatherford College
2023
Tianjin People's Hospital
2021
Photodynamic therapy (PDT) is a promising anticancer treatment and clinically approved for different types of tumors. However, current PDT suffers several obstacles, including its neutralization by excess glutathione (GSH) in the tumor tissue strongly proangiogenic response. In this work, biomimic, multifunctional nanoparticle-based agent, combining tumor-targeted photosensitizer with GSH scavenging antiangiogenesis therapy, developed. A porphyrinic Zr-metal-organic framework nanoparticle...
An effective tumor vaccine vector that can rapidly display neoantigens is urgently needed. Outer membrane vesicles (OMVs) strongly activate the innate immune system and are qualified as immunoadjuvants. Here, we describe a versatile OMV-based platform to elicit specific anti-tumor response via specifically presenting antigens onto OMV surface. We first on OMVs surface by fusing with ClyA protein, then simplify antigen process employing Plug-and-Display comprising tag/catcher protein pairs....
Pancreatic ductal adenocarcinoma is characterised by a dense desmoplastic stroma composed of stromal cells and extracellular matrix (ECM). This barrier severely impairs drug delivery penetration. Activated pancreatic stellate (PSCs) play key role in establishing this unique pathological obstacle, but also offer potential target for anti-tumour therapy. Here, we construct tumour microenvironment-responsive nanosystem, based on PEGylated polyethylenimine-coated gold nanoparticles, utilise it...
Combination therapeutic regimen is becoming a primary direction for current cancer immunotherapy to broad the antitumor response. Functional nanomaterials offer great potential steady codelivery of various drugs, especially small molecules, peptides, and nucleic acids, thereby realizing controllable drug release, increase bioavailability, reduction adverse effects. Herein, peptide assembling nanoparticle that can sequentially respond dual stimuli in tumor extracellular matrix was designed...
During pancreatic tumor development, stellate cells (PSCs) proliferate exuberantly to secrete extracellular matrix (ECM) in the stroma, which presents major barriers for drug delivery and penetration tissue. Thus, down-regulating ECM levels via regulation of PSCs may allow enhanced therapeutic drugs thereby enhancing their efficacy. To regulate PSCs, a metalloproteinase-2 (MMP-2) responsive peptide-hybrid liposome (MRPL) was constructed coassembly tailor-designed MMP-2 amphiphilic peptide...
Natural, extracellular membrane vesicles secreted by Gram-negative bacteria, outer (OMVs), contain numerous pathogen-associated molecular patterns which can activate systemic immune responses. Previous studies have shown that OMVs induce strong IFN-γ- and T cell-mediated anti-tumor effects in mice. However, IFN-γ is known to upregulate immunosuppressive factors the tumor microenvironment, especially checkpoint programmed death 1 ligand (PD-L1), may hamper cell function limit...
Biomimetic camouflage, i.e., using natural cell membranes for drug delivery, has demonstrated advantages over synthetic materials in both pharmacokinetics and biocompatibility, so represents a promising solution the development of safe nanomedicine. However, only limited efforts have been dedicated to engineering such camouflage endow it with optimized or additional properties, particular properties critical "smart" delivery system, as stimuli-responsive release. A pH-responsive biomimetic...
Excess iron deposition in the brain often causes oxidative stress-related damage and necrosis of dopaminergic neurons substantia nigra has been reported to be one major vulnerability factors Parkinson's disease (PD). Iron chelation therapy using deferoxamine (DFO) may inhibit this nigrostriatal degeneration prevent progress PD. However, DFO shows very short half-life vivo hardly penetrates blood barrier (BBB). Hence, it is great interest develop formulations for safe efficient intracerebral...
Rapid cut-off of blood supply in diseases involving thrombosis is a major cause morbidity and mortality worldwide. However, the current thrombolysis strategies offer limited results due to therapeutics' short half-lives, low targeting ability, unexpected bleeding complications. Inspired by innate roles platelets hemostasis pathological thrombus, platelet membrane-camouflaged polymeric nanoparticles (nanoplatelets) are developed for delivery thrombolytic drug, recombinant tissue plasminogen...
Overproduction of reactive oxygen species (ROS), a key characteristic inflammatory bowel disease (IBD), is responsible for dysregulation signal transduction, response, and DNA damage, which ultimately leads to progression deterioration. Thus, ROS scavenging has become promising strategy navigate IBD. Inspired by the targeting capability hyaluronic acid (HA) CD44-overexpressed cells together with redox regulation capacity diselenide compounds, we developed an oral nanoformulation, i.e.,...
Compared with traditional chemotherapeutics, vascular disruption agents (VDAs) have the advantages of rapidly blocking supply nutrients and starving tumors to death. Although VDAs are effective under certain scenarios, this treatment triggers angiogenesis in later stage therapy that frequently leads tumor recurrence failure. Additionally, nonspecific targeting considerable side effects also impede clinical applications VDAs. Here we develop a customized strategy combines VDA an...
Microbiota-based therapeutics offer innovative strategies to treat inflammatory bowel diseases (IBDs). However, the poor clinical outcome so far and limited flexibility of bacterial approach call for improvement. Inspired by health benefits probiotics in alleviating symptoms diseases, bioartificial are designed restore intestinal microenvironment colitis regulating redox balance, immune responses, gut microbiome. The probiotic comprises two components: an E. coli Nissle 1917-derived membrane...
An integrated cell-penetrating peptide-assembly-based nanomaterial is engineered as a dual-mode strategy for enhancing nanotherapeutic tumor targeting and penetration through recognition depletion of cancer-associated fibroblasts. The composed fibroblast-specific antibody overcoming tissue barrier cell-penetration peptide-mediated enhanced cellular uptake. As service to our authors readers, this journal provides supporting information supplied by the authors. Such materials are peer...
Prostate cancer is one of the most common malignant tumors in men, and inhibiting metastasis a key event but still major challenge prostate treatment. Cancer-associated fibroblasts (CAFs) play an important role tumor by shaping microenvironment. Herein, we constructed CAF-targeting siRNA delivery system loading fibroblast activation protein-α (FAP-α) antibody onto cell-penetrating peptide (CPP)-based nanoparticles, which specifically downregulated C–X–C motif chemokine ligand 12 (CXCL12)...
Multiple cell plasma membranes have been utilized for surface functionalization of synthetic nanomaterials and construction biomimetic drug delivery systems cancer treatment. The natural characters facile isolation original cells facilitate the biomedical applications in functionalizing nanocarriers. Human umbilical cord-derived mesenchymal stem (MSCs) identified to show tropism toward malignant lesions great advantages ease acquisition, low immunogenicity, high proliferative ability. Here,...
Fibrotic stroma, a critical character of pancreatic tumor microenvironment, provides barrier against the penetration and efficacy various antitumor drugs. Therefore, new strategies are urgently needed to alleviate fibrotic mass increase drug perfusion within cancer tissue. In our current work, we developed β-cyclodextrin (β-CD) modified matrix metalloproteinase-2 (MMP-2) responsive liposome, integrating antifibrosis chemotherapeutic drugs for regulation stellate cells (PSCs), key source...
Platinum (Pt)-based chemotherapy is a broadly used therapeutic regimen against various cancers. However, the insufficient cellular uptake, deactivation by thiol-containing species and nonspecific distribution of cisplatin (CDDP) result in its low chemosensitivity as well systemic side effects, which can largely constrain employment CDDP clinical treatment. To circumvent these problems, this study, polymeric nanoparticles were utilized to codeliver water-soluble derivative, poly(γ,l-glutamic...