A5022387921- Oral and Maxillofacial Pathology
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- Virus-based gene therapy research
- Facial Trauma and Fracture Management
- Bone Tumor Diagnosis and Treatments
- Bone and Dental Protein Studies
- Fibroblast Growth Factor Research
- Peptidase Inhibition and Analysis
- Phytochemicals and Antioxidant Activities
- Advanced MRI Techniques and Applications
- Soft tissue tumor case studies
- MRI in cancer diagnosis
- Tea Polyphenols and Effects
- Craniofacial Disorders and Treatments
- Acute Kidney Injury Research
- Wnt/β-catenin signaling in development and cancer
- Tumors and Oncological Cases
- CAR-T cell therapy research
- Plant Gene Expression Analysis
- Genetic Associations and Epidemiology
- Hippo pathway signaling and YAP/TAZ
- Sulfur Compounds in Biology
- Neuroinflammation and Neurodegeneration Mechanisms
- Connective Tissue Growth Factor Research
Wenzhou Medical University
2017-2024
Capital Institute of Pediatrics
2024
Dongyang People's Hospital
2024
Wuhan University
2023
He Eye Hospital
2023
Gansu Provincial Hospital
2023
Cotton Research Institute
2022
Chinese Academy of Agricultural Sciences
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2022
Peking Union Medical College Hospital
2017-2022
Combination therapeutic regimen is becoming a primary direction for current cancer immunotherapy to broad the antitumor response. Functional nanomaterials offer great potential steady codelivery of various drugs, especially small molecules, peptides, and nucleic acids, thereby realizing controllable drug release, increase bioavailability, reduction adverse effects. Herein, peptide assembling nanoparticle that can sequentially respond dual stimuli in tumor extracellular matrix was designed...
Alveolar cleft is the most common congenital bone defect. Autologous iliac crest graft (ICBG) widely adopted procedure for alveolar repair, but condition associated with door-site morbidities. For first time, this study used marrow mononuclear cells (BMMNCs) combined beta-tricalcium phosphate (β-TCP) granules to repair The effectiveness of technique was compared autologous ICBG after 12 months follow-up. formation volume quantitatively evaluated by three-dimensional computed tomography and...
Wnt1-inducible signaling protein 1 (WISP1) is a matricellular and downstream target of Wnt/β-catenin signaling. This study sought to determine the role WISP1 in glucose metabolism chemoresistance laryngeal squamous cell carcinoma. expression was silenced or upregulated Hep-2 cells by transfection siRNA AdWISP1 vector. Ectopic regulated uptake lactate production cells. Subsequently, transporter (GLUT1) significantly modulated WISP1. Furthermore, increased survival rates, diminished death...
Indoleamine 2,3-dioxygenase-1 (IDO1) plays an important role in tumor immune escape. However, unsatisfactory clinical efficacies of selective IDO1 inhibitors have impeded their further development, suggesting that they do not exert sufficient antitumor effects by selectively inhibiting IDO1. IDO2, isoenzyme IDO1, is overexpressed some human tumors, and emerging evidence suggests concomitant inhibition IDO1/2 may synergistic cancer treatment, revealing a promising immunotherapeutic strategy....
Human jaw bone marrow mesenchymal stem cells (h-JBMMSCs) are multipotent progenitor with osteogenic differentiation potential. The relationship between adiponectin (APN) and the metabolism of h-JBMMSCs has not been fully elucidated, underlying mechanism remains unclear. aim study was to investigate effect APN on h-JBMMSC metabolism. were obtained from primary culture human bones treated or without (1 µg/mL). Osteogenesis-related gene expression evaluated by real-time polymerase chain...
Objective: To determine the relationships between dopamine D2 receptor gene polymorphisms and risk of schizophrenia using meta-analysis. Method: The PubMed, Embase, China National Knowledge Infrastructure databases were searched to identify relevant literature published up February 2016. allele contrast model was used. STATA software used for statistical analysis, with odds ratios (ORs) 95% confidence intervals (CIs) calculated evaluate associations schizophrenia. Meta-regression publication...
Abstract Background Polyethyleneimine (PEI), which can interact with negatively charged DNA through electrostatic interaction to form nanocomplexes, has been widely attempted use as a gene delivery system. However, PEI some defects that are not fit for keeping on expression. Therefore, modifications against properties have done improve their application value in delivery. In this study, three modified derivatives, including poly(ε-caprolactone)-pluronic-poly(ε-caprolactone) grafted...
Purpose To investigate the effect of mitochondria‐targeted antioxidant MitoQ in reducing severity renal ischemia‐reperfusion injury (IRI) rats using T 2 ‐weighted imaging and dynamic contrast‐enhanced MRI (DCE‐MRI). Methods Ischemia‐reperfusion was induced by temporarily clamping left artery. Rats were pretreated with or saline. The examination performed before after IRI (days 2, 5, 7, 14). standardized signal intensity outer stripe medulla (OSOM) measured. unilateral clearance rate k cl...
The present study was aimed to elucidate the flavor formation mechanism of Changqing tea. High-performance liquid chromatography (HPLC) analysis showed that total catechins tea 65-160 mg/g, with 16-34 mg/g non-galloyated and 49-126 galloylated catechins. Tea polyphenols free amino acids account for 286-312 35-89 respectively. Transcriptome during different seasons revealed 316, 130 12 DEGs in comparisons spring vs. autumn, summer, summer Compared spring, genes involved flavonoid biosynthesis...
Pea-tea intercropping is an excellent cultivation method that can improve tea quality. However, the underlying mechanism still unclear. The present study was aimed at elucidating of effect pea-tea on quality through a high-throughput method. Transcriptome and metabolome analyses were conducted to identify changes in gene expression metabolites intercropping, respectively. In addition, amino acids catechins detected using LC-MS quantified absolutely. results showed total polyphenols decreased...
Abstract Background Congenital disorders of glycosylation (CDG) are a type inborn error metabolism (IEM) resulting from defects in glycan synthesis or failed attachment glycans to proteins lipids. One rare CDG is caused by homozygous compound heterozygous loss‐of‐function variants mannosidase alpha class 2B member 2 ( MAN2B2 ). To date, only two cases ‐CDG have been reported worldwide. Methods Trio whole‐exome sequencing (Trio‐WES) was conducted screen for candidate variants. N‐glycan...
Background: To develop a nomogram incorporating indicator of muscle waste to prognosticate long-term mortality in liver cirrhosis (LC), and identify the prognostic impact psoas index (PMI). Methods: A total 251 LC patients who underwent computed tomography were included this study. Multiple Cox regression was performed, sex-specific models PMI developed. The utility proposed evaluated by Harrell's concordance (C-index), calibration curve decision analysis. X-tile used determine optimal...
Diffusion weighted imaging (DWI), with the applying of intravoxel incoherent motion model, has showed promising results in obtaining additional information about microperfusion and tubular flow associated morphologic changes chronic kidney diseases. The study aims to evaluate potential T2-weighted signal intensity (SI) DWI mono- bi-exponential models reflect serial on cisplatin (CP) induced rat renal fibrosis models.Magnetic resonance exams were performed prior 2 nd day, 4 th 6 8 week, 3 rd...
Background Fibrous dysplasia (FD) is a tumor-like growth that consists of replacement the medullary bone with fibrous tissue, causing expansion and weakening areas involved. The most commonly affected bones are facial bones, number cosmetic functional problems. Methods From December 2008 to July 2012, 10 patients craniomaxillofacial were treated by conservative resection local recontouring. followed up yearly, an average 3 years; longest follow-up period was 5 years. Results All received...
The significance of melanoma differentiation-associated gene-7/interleukin-24 (MDA-7/IL-24) expression in head and neck squamous cell carcinoma (HNSCC) remains unclear. This study was designed to investigate evaluate the clinical MDA-7/IL-24 HNSCC by detecting immunostaining 131 specimens. function investigated real-time polymerase chain reaction (PCR) Western blot Ad5.mda-7-infected lines. Our results showed that mainly expressed cytoplasm cells. high patients presented with a favorable...
Regulatory and effector T cells possess immunological cytotoxicity for tumor in the microenvironment during progression are primary suppressors inhuman cancer therapy. Interleukin‑2 (IL‑2) is an anticancer cytokine, which triggers human innate adaptive immunity by stimulating cell propagation lymphocyte infiltration into sites. IL‑2 has been used successfully Recombinant adenovirus expressing (rAd‑IL‑2) injection a gene therapy agent that may improve prognosis of hepatocellular carcinoma...
Periodontal diseases are infections of the structures that surround and support teeth; they characterized by local inflammation alveolar bone loss. Most treatments focus on only one aspect, inhibiting inflammation, or promoting osteoblasts. We set out to develop a new method would intervene in two aspects simultaneously. Adiponectin (APN), secreted adipocytes, inhibits inflammatory response promotes osteogenesis. However, its role human periodontal ligament cells (hPDLCs) is unclear....
Liver transplantation has become the treatment of choice for patients with end-stage acute or chronic hepatic disease. Bile duct complications are common events after liver transplantation. The aim this study was to evaluate blood supply human bile and identify underlying mechanisms transplantation.The branches from gastroduodenal artery extrahepatic system were re-evaluated through selective angiography 600 patients. In addition, 33 cadavers injected latex casting material into artery, then...