A5100445886- Gut microbiota and health
- Neurogenetic and Muscular Disorders Research
- Genomics and Rare Diseases
- Diet and metabolism studies
- Genomics and Phylogenetic Studies
- RNA modifications and cancer
- Congenital limb and hand anomalies
- Genetics and Neurodevelopmental Disorders
- Genomic variations and chromosomal abnormalities
- Genetic Associations and Epidemiology
- Connective tissue disorders research
- Tryptophan and brain disorders
- Cancer-related molecular mechanisms research
- Clostridium difficile and Clostridium perfringens research
- Plant-Microbe Interactions and Immunity
- Genetic Syndromes and Imprinting
- Heavy metals in environment
- SARS-CoV-2 and COVID-19 Research
- Inflammasome and immune disorders
- Plant biochemistry and biosynthesis
- Amyotrophic Lateral Sclerosis Research
- Genomics and Chromatin Dynamics
- Connexins and lens biology
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
Harbin Medical University
2017-2025
Second Affiliated Hospital of Harbin Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2010-2025
Chongqing Medical University
2012-2025
Inner Mongolia University for Nationalities
2025
First Affiliated Hospital of Anhui Medical University
2000-2025
Anhui Medical University
2009-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023-2025
Shanghai University of Traditional Chinese Medicine
2013-2025
Mutations causing a rare skin disease reveal signaling pathway that is drug target for Alzheimer’s disease.
Ebola virus infection can cause severe hemorrhagic fever with a high mortality in humans. The outbreaks of viruses 2014 represented the most serious epidemics history and greatly threatened public health worldwide. development additional effective anti-Ebola therapeutic agents is therefore quite urgent. In this study, via throughput screening Food Drug Administration-approved drugs, we identified that teicoplanin, glycopeptide antibiotic, potently prevents entry envelope pseudotyped into...
A rod-shaped, Gram-stain-positive, obligately anaerobic, xylan-degrading bacterium, SK-Y3T, was isolated from oily-sludge of Shengli oilfield, China. Optimum growth occurred at 50 °C, pH 7.5 and without addition NaCl. The predominant cellular fatty acids strain SK-Y3T were iso-C15 : 0, anteiso-C15 0 iso-C17 the main polar lipids glycolipids (GL), (L), phosphatidylglycerol (PG) diphosphatidylglycerol (DPG); no respiratory quinones detected. genomic DNA G+C content 37.2 mol%. Phylogenetic...
Abstract gutMDisorder (http://bio-annotation.cn/gutMDisorder), a manually curated database, aims at providing comprehensive resource of dysbiosis the gut microbiota in disorders and interventions. Alterations composition microbial community play crucial roles development chronic disorders. And beneficial effects drugs, foods other intervention measures on could be microbially mediated. The current version documents 2263 associations between 579 microbes 123 or 77 Human, 930 273 33 151 Mouse....
Abstract gutMGene (http://bio-annotation.cn/gutmgene), a manually curated database, aims at providing comprehensive resource of target genes gut microbes and microbial metabolites in humans mice. Metagenomic sequencing fecal samples has identified 3.3 × 106 non-redundant from up to 1500 different species. One the contributions microbiota host biology is circulating pool bacterially derived small-molecule metabolites. It been estimated that 10% found mammalian blood are microbiota, where they...
Interindividual variability in pain perception and analgesic response is a major problem perioperative practice. Adult studies suggest management influenced by patient's race. The objective of this study to evaluate the influence race on treatment children.Prospective observational evaluating effect analgesia opioid related adverse effects after tonsillectomy African American Caucasian children. A sample 194 healthy children between 6 15 years age were included. Race was self-identified...
Parkinson's disease (PD) is a common age-related neurodegenerative movement disorder, which mainly due to the loss of dopaminergic neurons. Pyroptosis new programmed cell death characterized by NLR Family Pyrin Domain Containing 3 (NLRP3)-dependent, IL-1β, IL-18 and Gasdermin D. Salidroside (Sal) has been reported have neuro-protective effect. However, roles pyroptosis Sal on anti-pyroptosis in PD not elucidated. In this study, we tested underlying mechanisms effects Sal. We established...
This research aimed to determine the prevalence of workplace violence (WPV) against healthcare workers, explore frequency distribution in different occupational groups, and which occupation suffers from WPV most frequently. Furthermore, current study compare risk factors affecting types Chinese hospitals. A cross-sectional design was utilized. total 1899 workers Heilongjiang, a province Northeastern China, completed questionnaire. Of respondents, 83.3% reported exposure violence, 68.9%...
Chlorogenic acid (CGA) is one of the most abundant polyphenols in human diet and suggested to be a potential antiatherosclerotic agent due its proposed hypolipidemic, anti-inflammatory antioxidative properties. The aim this study was evaluate effect CGA on atherosclerosis development ApoE−/− mice mechanism. were fed cholesterol-rich without (control) or with (200 400 mg/kg) atorvastatin (4 for 12 weeks. During plasma lipid inflammatory parameters determined. Treatment (400 reduced...
Antibody-decorated liposomes can facilitate the precise delivery of chemotherapeutic drugs to lung by targeting a recognition factor present on surface tumor cells. Carbonic anhydrase IX (CA IX) is an enzyme expressed cancer cells with restricted expression in normal lungs. Here, we explored utility anti-carbonic antibody, conjugated triptolide (TPL)-loaded IX-TPL-Lips), promote therapeutic effects for via pulmonary administration. It was found that CA IX-TPL-Lips significantly improved...
The ligands of mitochondrial translocator protein (TSPO) have been widely used as diagnostic biomarkers for glioma. However, the true biological actions TSPO in vivo and its role glioma tumorigenesis remain elusive.
Abstract Gut microbiota plays a significant role in maintaining host health, and conversely, disorders potentially lead to dysbiosis, an imbalance the composition of gut microbial community. Intervention approaches, such as medications, diets, several others, also alter either beneficial or harmful direction. In 2020, gutMDisorder was developed facilitate researchers investigation dysbiosis microbes occurs various well with therapeutic interventions. The database has been updated this year,...
Amorphophallus albus is an herbaceous, cormous, perennial plant used as a food source and traditional medicine in Asia.In this study, we assembled annotated the complete mitochondrial genome (mitogenome) of A. albus. Then analyzed repeated elements plastid sequences (MTPTs), predicted RNA editing sites protein-coding genes (PCGs). Lastly, inferred phylogenetic relationships other angiosperms based on PCGs, designed two molecular markers DNA.The mitogenome consists 19 circular chromosomes....