A5100448446- Medicinal Plants and Bioactive Compounds
- stochastic dynamics and bifurcation
- Optimism, Hope, and Well-being
- Spectroscopy and Quantum Chemical Studies
- Natural Compounds in Disease Treatment
- Pharmacological Effects of Natural Compounds
- Asymmetric Synthesis and Catalysis
- Natural product bioactivities and synthesis
- Eicosanoids and Hypertension Pharmacology
- Peroxisome Proliferator-Activated Receptors
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Chemical Synthesis and Analysis
- Biomarkers in Disease Mechanisms
- Receptor Mechanisms and Signaling
- Autophagy in Disease and Therapy
- Traditional Chinese Medicine Analysis
- Nicotinic Acetylcholine Receptors Study
- Oxidative Organic Chemistry Reactions
- Gene Regulatory Network Analysis
- Rheumatoid Arthritis Research and Therapies
- Ginseng Biological Effects and Applications
- Synthetic Organic Chemistry Methods
China Pharmaceutical University
2015-2022
Salidroside (Sal) is an active ingredient that isolated from Rhodiola rosea, which has been reported to have anti-inflammatory activities and a renal protective effect. However, the role of Sal on fibrosis not yet elucidated. Here, purpose current study test effects against interstitial (RIF), explore underlying mechanisms using both in vivo vitro models. In this study, we establish unilateral ureteric obstruction (UUO) or folic acid (FA)-induced mice transforming growth factor...
Parkinson's disease (PD) is a common age-related neurodegenerative movement disorder, which mainly due to the loss of dopaminergic neurons. Pyroptosis new programmed cell death characterized by NLR Family Pyrin Domain Containing 3 (NLRP3)-dependent, IL-1β, IL-18 and Gasdermin D. Salidroside (Sal) has been reported have neuro-protective effect. However, roles pyroptosis Sal on anti-pyroptosis in PD not elucidated. In this study, we tested underlying mechanisms effects Sal. We established...
β-Functionalization of indolin-2-one-derived aliphatic acids has been applied in formal [3 + 2] annualtions for catalyst-free and divergent synthesis two series structurally interesting 3,3'-spirooxindole γ-butyrolactones that may be attractive potential drug discovery. These findings also pave the way further diversity-oriented spirooxindoles starting from or their derivatives.
Oligo-basic amino acids have been extensively studied in molecular biology and pharmacology, but the inhibitory activity on nicotinic acetylcholine receptors (nAChRs) was unknown. In this study, of 8 oligopeptides, including both basic acidic acids, evaluated 9 nAChR subtypes by a two-electrode voltage clamp (TEVC). Among them, oligo-lysine K9, K12, d-K9, d-K9F, oligo-arginine R9 showed nanomolar various nAChRs, especially for α7 α9α10 nAChRs. d-K9 containing N-Fmoc protecting group (d-K9F)...
Abstract As a potential tool for amplifying weak chromatographic peaks, the stochastic resonance algorithm was developed based upon counterintuitive physical phenomenon. Therefore, essential step, parameter optimization, perplexing and difficult analysts. In order to avoid optimizing system parameters on case‐by‐case basis, an improved proposed by introducing constant or direct current signal into be measured as external force. The peak can amplified detected new using same set of...
Sepsis, a systemic inflammatory response syndrome (SIRS) caused by infection, is major public health concern with limited therapeutic options. Infection disturbs the homeostasis of host, resulting in excessive inflammation and immune suppression. This has prompted clinical use immunomodulators to balance host as an alternative strategy. Here, we report that Thymopentin (TP5), synthetic immunomodulator pentapeptide (Arg-Lys-Asp-Val-Tyr) excellent safety profile clinic, protects mice against...