A5100395350- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Cholesterol and Lipid Metabolism
- RNA modifications and cancer
- GABA and Rice Research
- Cannabis and Cannabinoid Research
- MicroRNA in disease regulation
- Polyamine Metabolism and Applications
- Lipoproteins and Cardiovascular Health
- Ferroptosis and cancer prognosis
- Pain Mechanisms and Treatments
- Circular RNAs in diseases
- Plant-based Medicinal Research
- RNA Research and Splicing
- Prostate Cancer Treatment and Research
- Neuropeptides and Animal Physiology
- Hippo pathway signaling and YAP/TAZ
- Microtubule and mitosis dynamics
- Phytochemicals and Antioxidant Activities
- Receptor Mechanisms and Signaling
- Ubiquitin and proteasome pathways
- Berberine and alkaloids research
- Sarcoma Diagnosis and Treatment
- Fatty Acid Research and Health
- Hops Chemistry and Applications
Institute of Indigenous Peoples' Health
2023-2024
Beijing Proteome Research Center
2021-2024
Jining First People's Hospital
2024
Shandong First Medical University
2024
Jinan University
2024
Shanghai Tenth People's Hospital
2024
Tongji University
2024
Burnaby Hospital
2024
Beijing Fengtai Hospital
2024
Tianjin Medical University
2021-2023
Salidroside (Sal) is an active ingredient that isolated from Rhodiola rosea, which has been reported to have anti-inflammatory activities and a renal protective effect. However, the role of Sal on fibrosis not yet elucidated. Here, purpose current study test effects against interstitial (RIF), explore underlying mechanisms using both in vivo vitro models. In this study, we establish unilateral ureteric obstruction (UUO) or folic acid (FA)-induced mice transforming growth factor...
Background and Aims: Liver HCC is the second leading cause of cancer-related deaths worldwide. The heterogeneity this malignancy driven by a wide range genetic alterations, to lack effective therapeutic options. In study, we conducted systematic multi-omics characterization uncover its metabolic reprogramming signature. Approach Results: Through comprehensive analysis incorporating transcriptomic, metabolomic, lipidomic investigations, identified significant changes in pathways related...
Development of intelligent nanoplatforms that can simultaneously target multiple factors associated with tumor growth and metastasis remains an extreme challenge. Here, dendritic nanodevice incorporating both copper sulfide nanoparticles (CuS NPs) 5,6-dimethylxanthenone-4-acetic acid (DMXAA, a vascular disrupting agent) within the dendrimer internal cavities surface modified targeting agent LyP-1 peptide is reported. The resulting generation 5 (G5) dendrimer-based nanodevice, known as...
This study aimed to evaluate the blood concentrations of quercetin in healthy participants after administration different formulations single- and multiple-dose phases. Ten adults (males, 5; females, age 37 ± 11 years) participated a diet-controlled, crossover pilot study. Participants received three doses (250 mg, 500 or 1000 mg) aglycone orally. In single-dose study, (AUC0-24 Cmax) standard were compared with those LipoMicel®-a food-grade delivery form quercetin. formulated observed over...
Long noncoding RNAs (LncRNAs) are very important in the way that docetaxel resistance (DR) happens prostate cancer (PCa) patients. ImmuneScore and StromalScore were calculated using PCa-related expression data from TCGA ESTIMATE algorithm. We finally found DEGs related to immune system stroma of patients by making profiles StromalScore. The CancerSubtypes algorithm identified prognosis-related PCa subtypes, GSVA assessed their pathway activity. A UniCox regression analysis was used identify...
The Hippo signaling pathway plays an essential role in organ size control and tumorigenesis. Loss of signal hyper-activation the downstream oncogenic YAP are commonly observed various types cancers. We previously identified STRN3-containing PP2A phosphatase as a negative regulator MST1/2 kinases (i.e., Hippo) gastric cancer (GC), opening possibility selectively targeting PP2Aa-STRN3-MST1/2 axis to recover against cancer. Here, we further discovered 1) disulfiram (DSF), FDA-approved drug,...
// Xiangquan Mi 1, 2 , Chunming Wang 1 Chao Sun 3 Xu Chen Xiang Huo Yiming Zhang Gang Li Bo Jun 4 Jianxin Xie Zhenhua Ji School of Life Sciences, Lanzhou University, Lanzhou, Gansu 730000, P.R. China Center for Mitochondrial and Healthy Aging, College Yantai Yantai, Shandong 264005, Institute Modern Physics, Chinese Academy Shihezi University Medicine, Shihezi, Xinjiang 832000, Correspondence to: Li, email: lijimelissafang@yahoo.com Keywords: xanthohumol, paraptosis, p38-MAPK, cytoplasmic...
The management of castration-resistant prostate cancer (CRPC) is challenging, attributable to a lack efficacious therapies. Chemotherapy one the most important treatments for CRPC. Doxorubicin has been extensively used in many different tumors and often combined with other drugs enhance effects reduce toxicity. Costunolide natural sesquiterpene lactone anti-cancer properties. In this study, we first demonstrated that combination costunolide doxorubicin induced apoptosis significantly more...
Although cholesterol metabolism is a common pathway for the development of antitumor drugs, there are no specific targets and drugs clinical use. Here, based on our previous study sterol O-acyltransferase 1 (SOAT1) in hepatocelluar carcinoma, we sought to screen an effective targeted drug precise treatment carcinoma and, from perspective metabolism, clarify relationship between regulation tumorigenesis development.In this study, developed virtual screening integrated affinity technology...
Trapping of methylglyoxal (MGO), an important precursor advanced glycation end products (AGEs), is considered effective therapy for alleviating AGE-induced chronic metabolic diseases. In this paper, taxifolin (Tax) was first found to effectively trap MGO by forming mono- and di-MGO adducts under in vitro conditions. addition, the mechanism trapping Tax also studied vivo. demonstrated efficiently endogenous via formation mono-MGO urine fecal samples C57BL/6J mice after oral administration...
Berberine is a plant-origin quaternary isoquinoline alkaloid with vast array of biological activities, including antioxidant and blood-glucose- blood-lipid-lowering effects. However, its therapeutic potential largely limited by poor oral bioavailability. The aim this study was to investigate the in vitro solubility Caco-2 cell permeability followed pharmacokinetic profiling healthy volunteers new food-grade berberine delivery system (i.e., LipoMicel®). X-ray diffractometry (XRD), solubility,...
The high rate of postoperative recurrence contributes to the poor outcome in hepatocellular carcinoma (HCC), and effective strategies for managing are currently lacking. Based on seven pairs tumors non-tumor adjacent tissues (NATs) proteomic datasets across five cancer types, this study systematically investigates stratified therapeutic value NATs tumor recurrence. exhibited stable irreplaceable independent prognostic capabilities recurrence, complementing clinical indicators...
Background: Long noncoding RNA (lncRNA) GATA6-AS regulates the growth of endothelial cells, indicating its involvement in human diseases. The present study aimed to investigate roles glioma. Results: was significantly upregulated levels plasma positively and correlated with expression glioma tissues. TUG1 downregulated inversely GATA6-AS. overexpression led downregulation, whereas failed affect promoted cell proliferation inhibited apoptosis, attenuated effects overexpression. Conclusions:...
Therapy options for prostate cancer (PCa) typically are centered on docetaxel-based chemotherapy but limited by the effects of multi-drug resistance. Recent advances have illustrated a role contactin-1 (CNTN-1) in tumor chemoresistance, while function and mechanism CNTN-1 resistance docetaxel not yet been elucidated.Docetaxel (Dox)-resistant PCa cell lines PC3 (PC3-DR) DU145 (DU145-DR) were established, short hairpin RNA (shRNA) constructs targeting generated to analyze effect knockdown...
Hepatocellular carcinoma (HCC) accounts for over 80% of cases among liver cancer, with high incidence and poor prognosis. Thus, it is valuable clinical significance discovery potential biomarkers drug targets HCC. In this study, based on the proteomic profiling data paired early-stage HCC samples, we found that RNF149 was strikingly upregulated in tumor tissues correlated prognosis patients, which further validated by IHC staining experiments an independent cohort. Consistently,...
Research on the implications of ferroptosis in tumors has increased rapidly last decades. There are evidences that is involved several aspects cancer biology, including tumor progression, metastasis, immunomodulation, and therapeutic response. Nonetheless, interaction between ferroptosis-related lncRNAs (FRLs) osteosarcoma immune microenvironment poorly understood. In this study, a risk model composed FRLs was developed using univariate LASSO Cox regression analyses. On basis model, FRL...
This study evaluated the differences in metabolite profile of three n-3 FA fish oil formulations 12 healthy participants: (1) standard softgels (STD) providing 600 mg FA; (2) enteric-coated (ENT) (3) a new micellar formulation (LMF) 374 FA. The pharmacokinetics (PKs), such as area under plot plasma concentration (AUC), and peak blood (C
Ginger (Zingiber officinale Rosc.) is an important spice crop valued for its flavored and medical properties. It susceptible to soil-borne diseases, which can cause considerable economic loss growers. In vitro culture feasible the propagation of disease-free ginger plants, but has several disadvantages when producing seed rhizomes that be commercially used, such as long cultivation cycles (usually 2–3 years) occurrence somaclonal variation. this study, dynamic changes in morphological...
Background Osteosarcoma is the most common primary malignant bone tumor. The existing treatment regimens remained essentially unchanged over past 30 years; hence prognosis has plateaued at a poor level. Precise and personalized therapy yet to be exploited. Methods One discovery cohort (n=98) two validation cohorts (n=53 & n=48) were collected from public data sources. We performed non-negative matrix factorization (NMF) method on stratify osteosarcoma. Survival analysis...
Cadmium (Cd), a heavy metal, is used in wide range of applications, such as plastics, electroplating process, electronics, and so forth. Due to its bioaccumulation ability, Cd can contaminate soil, water, air food. To determine the effect exposure on necroptosis pig spleen mechanistic investigation, we constructed model pigs by feeding them food containing 20 mg/kg Cd. In this study, analyzed effects through HE staining, Quantitative real-time PCR (qRT-PCR), Western blot (WB), principal...