A5073955580- Dental materials and restorations
- Hedgehog Signaling Pathway Studies
- Endodontics and Root Canal Treatments
- Bone Metabolism and Diseases
- Oral and Maxillofacial Pathology
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
- Dental Radiography and Imaging
- Oral microbiology and periodontitis research
- Bone health and treatments
- Epigenetics and DNA Methylation
- Oral and gingival health research
- Bone and Dental Protein Studies
- TGF-β signaling in diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Biomarkers in Disease Mechanisms
- Dental Implant Techniques and Outcomes
- Bone and Joint Diseases
- Lymphatic System and Diseases
- Dental Anxiety and Anesthesia Techniques
- Tumors and Oncological Cases
- Bioactive Compounds and Antitumor Agents
- Plant Virus Research Studies
- Osteoarthritis Treatment and Mechanisms
- Laser Applications in Dentistry and Medicine
Peking University
2011-2023
National Clinical Research Center for Digestive Diseases
2020-2023
King University
2023
Stomatology Hospital
2015-2022
Central Region Agricultural Research Center
2011
Human jaw bone marrow mesenchymal stem cells (h-JBMMSCs) are multipotent progenitor with osteogenic differentiation potential. The relationship between adiponectin (APN) and the metabolism of h-JBMMSCs has not been fully elucidated, underlying mechanism remains unclear. aim study was to investigate effect APN on h-JBMMSC metabolism. were obtained from primary culture human bones treated or without (1 µg/mL). Osteogenesis-related gene expression evaluated by real-time polymerase chain...
Adiponectin (APN) is known to promote the osteogenic differentiation of human jaw bone marrow mesenchymal stem cells (h-JBMMSCs). However, underlying mechanism has not been fully elucidated. Previously, we showed that APN could h-JBMMSC osteogenesis via APPL1-p38 by up-regulating osteogenesis-related genes. Here, aimed determine whether chemotaxis through CXCL1/CXCL8. The CCK-8, wound healing and transwell assays were used evaluate proliferation, migration h-JBMMSCs with or without...
Abstract Objective To explore the role of CD10 in cisplatin resistance oral squamous cell carcinoma (OSCC) and its association with Hedgehog (Hh) signaling pathway cancer stem cells (CSCs). Methods The correlation between viability expression was analyzed different OSCC lines after treatment. Genes related to chemotherapy resistance, epithelial–mesenchymal transition were detected by quantitative real‐time PCR (qPCR) high low cells. Mouse xenograft model venous metastasis used potential...
The significance of melanoma differentiation-associated gene-7/interleukin-24 (MDA-7/IL-24) expression in head and neck squamous cell carcinoma (HNSCC) remains unclear. This study was designed to investigate evaluate the clinical MDA-7/IL-24 HNSCC by detecting immunostaining 131 specimens. function investigated real-time polymerase chain reaction (PCR) Western blot Ad5.mda-7-infected lines. Our results showed that mainly expressed cytoplasm cells. high patients presented with a favorable...
Abstract Background Cancer stem cells (CSCs) drive tumor initiation and progression participate in chemoresistance. We recently discovered that oral squamous cell carcinoma (OSCC) highly express CD10 (CD10H cells) present cancer (CSC)-associated characteristics, which, turn, affect the growth, epithelial-mesenchymal transition (EMT), resistance to cisplatin. In this study, we further investigated mechanism vitro vivo . hypothesized IL8 might regulate migration, invasion, cisplatin of...
A plastic and biodegradable bone substitute consists of poly (L-lactic-co-glycolic) acid 30 wt % β-tricalcium phosphate has been previously fabricated, but its osteogenic capability required further improvement. We investigated the use globular adiponectin (gAPN) as an anabolic agent for tissue-engineered using this scaffold. qualitative analysis regeneration process was carried out μCT histological 12 weeks after implantation. CBCT (Cone Beam Computed Tomography) superimposition used to...
Objective: Refractory infection is an important factor affecting the progression of medication-related osteonecrosis jaw (MRONJ) from clinical stage I to II/III. The aim this study was explore distribution bacteria and their association with inflammatory pathway II/III MRONJ.Materials Methods: Nine specimens fresh inflammation tissue, located next necrotic bone or sequestrum, were collected MRONJ patients. normal oral mucosa healthy 16S rRNA gene sequencing method used determine...
Oral squamous cell carcinoma (OSCC) is an aggressive tumor that usually invades the maxilla or mandible. The extent and pattern of mandibular bone invasion caused by OSCC are most important factors determining treatment plan patients' prognosis. Yet, process not fully understood. following study explores molecular mechanism regulates focusing on morphogenetic protein receptor 1α (BMPR1α) Sonic hedgehog (SHH) signals. We found BMPR1α was positively correlated to defect patients....
Periodontal diseases are infections of the structures that surround and support teeth; they characterized by local inflammation alveolar bone loss. Most treatments focus on only one aspect, inhibiting inflammation, or promoting osteoblasts. We set out to develop a new method would intervene in two aspects simultaneously. Adiponectin (APN), secreted adipocytes, inhibits inflammatory response promotes osteogenesis. However, its role human periodontal ligament cells (hPDLCs) is unclear....
An occlusal veneer is an ultrathin restoration method and a minimally invasive approach that can preserve more dental tissue provide better aesthetic outcomes, thus increasing patient satisfaction.
There are numerous clinical cases indicating that long-term use of bevacizumab may increase the invasiveness tumors. However, to date, little is known about underlying molecular mechanisms. Therefore, purpose our study was investigate effects in four cancer cells lines (WSU-HN6, CAL27, Tca83, and HeLa). It found promote migration invasion WSU-HN6 Tca83 cases, while exerting inhibitory CAL27 HeLa cells. The signal transducer activator transcription (STAT) 3 inhibitors niclosamide S3I-201...
Abstract Background To evaluate the treatment outcomes of cracked tooth restored using occlusal veneer. Methods Thirty-seven with normal pulp or reversible pulpitis were analyzed, and their demographic clinical data medical history collected. Patients followed-up to examine thermal/biting sensitivity features. Results The maxillary first molar was most prevalent (N = 17, 46%), patients could accurately locate offending teeth 32, 83.5%). crack lines (CL) divided into 5 types depending on...
Sessions C412infected by highly pathogenic H5N1 type and H7N7 avian influenza.There is a clear need for new anti-influenza drugs to combat such viruses, especially as resistance the current Tamiflu Relenza already widespread.The RNA polymerase attractive target since it plays variety of essential roles in viral life-cycle more conserved than other proteins.We concentrated our research efforts on structural studies complex order assist structure-based drug design.Influenza virus RNAdependent...