A5006122700- Enzyme Structure and Function
- Bacteriophages and microbial interactions
- Protein Structure and Dynamics
- Plant Virus Research Studies
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ion channel regulation and function
- Biochemical and Molecular Research
- Photosynthetic Processes and Mechanisms
- RNA and protein synthesis mechanisms
- Viral gastroenteritis research and epidemiology
- Diabetes Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Enzyme Production and Characterization
- Glycosylation and Glycoproteins Research
- COVID-19 Clinical Research Studies
- Advanced X-ray Imaging Techniques
- RNA modifications and cancer
- Glutathione Transferases and Polymorphisms
- Microtubule and mitosis dynamics
- Amino Acid Enzymes and Metabolism
- Respiratory Support and Mechanisms
- Pancreatic function and diabetes
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
Kobe City Medical Center General Hospital
2015-2025
Nagoya University
2002-2025
Osaka University
2015-2024
Kanazawa Medical University
2013-2024
Kyoto University
2005-2024
Protein Research Foundation
2014-2023
National Synchrotron Radiation Research Center
2023
Kure Kyosai Hospital
2016-2023
Tohoku University
2023
Tsinghua University
2023
The Protein Data Bank (PDB) is the single global archive of experimentally determined three-dimensional (3D) structure data biological macromolecules. Since 2003, PDB has been managed by Worldwide (wwPDB; wwpdb.org), an international consortium that collaboratively oversees deposition, validation, biocuration, and open access dissemination 3D macromolecular data. Core Archive houses atomic coordinates more than 144 000 structural models proteins, DNA/RNA, their complexes with metals small...
Pre-MicroRNA Export Machinery Micro (mi) RNAs play a role in the regulation of many biological processes. Long transcripts are initially processed nucleus to yield pre-miRNAs that translocated through nuclear pore complex and further mature miRNAs cytoplasm. Okada et al. (p. 1275 ; see Perspective by Stewart ) describe crystal structure pre-miRNA complexed with exportin Exp5 small GTPase RanGTP. The shows RanGTP protect miRNA from degradation nucleases, as well facilitate transport RNA...
Favipiravir is an oral broad-spectrum inhibitor of viral RNA-dependent RNA polymerase that approved for treatment influenza in Japan. We conducted a prospective, randomized, open-label, multicenter trial favipiravir the COVID-19 at 25 hospitals across Eligible patients were adolescents and adults admitted with who asymptomatic or mildly ill had Eastern Cooperative Oncology Group (ECOG) performance status 0 1. Patients randomly assigned 1:1 ratio to early late therapy (in latter case, same...
The OprM lipoprotein of Pseudomonas aeruginosa is a member the MexAB-OprM xenobiotic-antibiotic transporter subunits that assumed to serve as drug discharge duct across outer membrane. channel structure must differ from porin-type open pore because protein facilitates exit antibiotics but not entry. For better understanding structure-function linkage this important pump subunit, we studied x-ray crystallographic at 2.56-Å resolution. overall exhibited trimeric assembly monomer consisted...
The sterol regulatory element–binding protein 2 (SREBP-2), a nuclear transcription factor that is essential for cholesterol metabolism, enters the nucleus through direct interaction of its helix-loop-helix leucine zipper domain with importin-β. We show crystal structure importin-β complexed active form SREBP-2. Importin-β uses characteristic long helices like pair chopsticks to interact an SREBP-2 dimer. changes conformation reveal pseudo-twofold symmetry on surface so it can accommodate...
Among proglucagon-derived peptides, the truncated form of glucagon-like peptide-1, GLP-1(7-36)amide (tGLP-1), is known as most likely physiological humoral incretin. To examine whether there exists any relationship between tGLP-1 levels in portal vein and activities hepatic pancreatic vagal system, changes impulse discharge rate afferent vagus efferent upon intraportal injection were measured situ rats anesthetized with urethan chloralose. First, a 1-min bolus at periphysiological dose 0.2...
Methylation of cytosine in DNA plays a crucial role development through inheritable gene silencing. The methyltransferase Dnmt1 is responsible for the propagation methylation patterns to next generation via its preferential hemimethylated CpG sites genome; however, how maintains not fully understood. Here we report crystal structure large fragment (291–1620) mouse and complexes with cofactor S -adenosyl-L-methionine product -adenosyl-L-homocystein. Notably, absence DNA, N-terminal domain...
The Protein Data Bank Japan (PDBj, http://pdbj.org) is a member of the worldwide (wwPDB) and accepts processes deposited data experimentally determined macromolecular structures. While maintaining archive in collaboration with other wwPDB partners, PDBj also provides wide range services tools for analyzing structures functions proteins, which are summarized this article. To enhance interoperability PDB data, we have recently developed PDB/RDF, Resource Description Framework (RDF) format,...
Pulmonary alveolar proteinosis is a disease characterized by abnormal accumulation of surfactant in the alveoli. Most cases are autoimmune and associated with an autoantibody against granulocyte–macrophage colony-stimulating factor (GM-CSF) that prevents clearing pulmonary macrophages. An open-label, phase 2 study showed some therapeutic efficacy inhaled recombinant human GM-CSF patients severe proteinosis; however, mild-to-moderate remains unclear.