A5067826877- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Sarcoidosis and Beryllium Toxicity Research
- Asthma and respiratory diseases
- Medical Imaging and Pathology Studies
- Congenital Diaphragmatic Hernia Studies
- Inhalation and Respiratory Drug Delivery
- Immune Cell Function and Interaction
- Respiratory and Cough-Related Research
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Pediatric health and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mast cells and histamine
- Peptidase Inhibition and Analysis
- Tuberculosis Research and Epidemiology
- Pulmonary Hypertension Research and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pneumonia and Respiratory Infections
- Drug-Induced Adverse Reactions
- Monoclonal and Polyclonal Antibodies Research
- Antibiotics Pharmacokinetics and Efficacy
- Mycobacterium research and diagnosis
- Lung Cancer Research Studies
- Inflammasome and immune disorders
Aichi Medical University
2015-2025
Gifu Prefectural Tajimi Hospital
2022
Aichi Medical University Hospital
2019-2020
First Affiliated Hospital of Xi'an Jiaotong University
2019
Rakuwakai Otowa Hospital
2019
St Mary's Hospital
2012
St. Mary's Hospital
2012
Imperial College London
2012
Niigata University
2012
Cincinnati Children's Hospital Medical Center
2012
Section:ChooseTop of pageAbstract <<METHODSRESULTSDISCUSSIONAPPENDIXReferencesCITING ARTICLES
Inhaled granulocyte/macrophage-colony stimulating factor (GM-CSF) is a promising therapy for pulmonary alveolar proteinosis (PAP) but has not been adequately studied.To evaluate safety and efficacy of inhaled GM-CSF in patients with unremitting or progressive PAP.We conducted national, multicenter, self-controlled, phase II trial at nine centers throughout Japan. Patients who had lung biopsy cytology findings diagnostic PAP, an elevated serum antibody level, Pa(O(2)) less than 75 mm Hg...
Pulmonary alveolar proteinosis is a disease characterized by abnormal accumulation of surfactant in the alveoli. Most cases are autoimmune and associated with an autoantibody against granulocyte–macrophage colony-stimulating factor (GM-CSF) that prevents clearing pulmonary macrophages. An open-label, phase 2 study showed some therapeutic efficacy inhaled recombinant human GM-CSF patients severe proteinosis; however, mild-to-moderate remains unclear.
Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease characterized by progressive surfactant accumulation and hypoxemia. It caused disruption of granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling, which macrophages require to clear surfactant. Recently, inhaled GM-CSF was shown improve the partial pressure arterial oxygen in patients with aPAP. In double-blind, placebo-controlled, three-group trial, we randomly assigned aPAP receive recombinant molgramostim...
The CC chemokine regulated upon activation, normal T-cell expressed and secreted (RANTES) attracts eosinophils, basophils, T cells during inflammation immune response, indicating a possible role for this in asthma. Both the -403A -28G alleles of RANTES promoter region exhibit significantly enhanced activity reporter constructs vitro. We therefore investigated genetic influence these on development asthma using case-control analysis Japanese population (298 patients with 311 control...
Although no report has demonstrated the efficacy of corticosteroid therapy for autoimmune pulmonary alveolar proteinosis (aPAP), we sometimes encounter patients who have received this various reasons. However, as corticosteroids can suppress macrophage function, might worsen disease severity and increase risk infections. For retrospective cohort study, sent a screening form to 165 institutions asking information on aPAP treated with corticosteroids. Of resulting 45 screened, 31 were enrolled...
Abstract Pulmonary alveolar proteinosis (PAP) is a devastating lung disease caused by abnormal surfactant homeostasis, with prevalence of 6–7 cases per million population worldwide. While mutations causing hereditary PAP have been reported, the genetic basis contributing to autoimmune (aPAP) has not thoroughly investigated. Here, we conducted genome-wide association study aPAP in 198 patients and 395 control participants Japanese ancestry. The common variant, rs138024423 at 6p21,...
A number of chemokines are produced by alveolar cells in the course inflammatory reactions sarcoidosis. C-C chemokine receptor 2 (CCR2) is a prominent for monocyte chemoattractant protein (MCP) group chemokines. transition causing valine to isoleucine substitution transmembrane domain I CCR2 gene (CCR2-64I) that has protective effect against progression human immunodeficiency virus-1 (HIV-1) disease been described. To elucidate role this polymorphism sarcoidosis, we investigated distribution...
BACKGROUND: Genetic control of serum angiotensin I converting enzyme (SACE) levels has been suggested. A study was undertaken to elucidate the role this polymorphism in sarcoidosis. METHODS: Three hundred and forty one unrelated healthy controls 103 consecutive patients with sarcoidosis participated study. SACE an insertion/deletion (I/D) intron 16 ACE gene were studied each subject new reference intervals for activity genotype determined. The difference allele frequencies between analysed...
Summary Background IL‐18 has been shown to exert anti‐allergic or allergy‐promoting activities, but the existence of genetic polymorphisms in coding regions gene not demonstrated. Objective The aim this study was investigate whether polymorphism is present and, if so, further analyse association between and asthma a case–control study. Methods We screened for by using PCRsingle‐stranded conformation direct sequencing PCR products, followed analysis asthma. Results identified one (105A/C)...
Summary Atopy as defined in terms of IgE responsiveness was reported to be controlled by a single gene British families, and this concept further supported significant linkage between atopy restriction fragment length polymorphism (RFLP) detected DNA probe specific chromosome 11q13. To confirm observation Japanese population, segregation analyses were done four large families. Although patterns agreement with the pattern autosomal dominant inheritance, there no locus Alterations definitions...
Angiotensin-converting enzyme (ACE) genotypes may reflect prognosis in sarcoidosis. They were determined 59 Finnish sarcoidosis patients and 70 healthy control subjects. The of the was after follow-up for 1, 2, 3, 5 >5 yrs classified as good (normal chest radiograph lung function, no signs extrapulmonary disease activity within 2 from diagnosis), intermediate (neither nor poor) or poor (persisting unstable pulmonary infiltrates, vital capacity diffusing carbon monoxide <50% predicted and/or...
Susceptibility to asthma and other atopic diseases is known be associated with elevated total IgE levels. Several investigators have linked the interleukin‐4 (IL‐4) gene nearby markers located on chromosome 5q A single nucleotide polymorphism in IL‐4 promoter region (C+33T) has recently been identified. As part of an effort identify genetic variants contributing susceptibility serum levels, association analysis a newly identified levels was conducted. The study conducted using 240 Japanese...
To evaluate the mechanism by which cigarette smoking suppresses pulmonary immune responses, we determined capacity of alveolar macrophages (AM) to produce interleukin 1 (IL-1) in 32 normal subjects and 40 patients with sarcoidosis. The amount IL-1 released from LPS-stimulated AM smokers was significantly decreased compared that nonsmokers both sarcoid groups. addition indomethacin cultures 18 22 sarcoidosis yielded similar results, thus excluding possibility this difference resulted a...
Computed tomography (CT)-guided lung biopsy is commonly used to make a histological diagnosis for pulmonary lesions. Its most common complication pneumothorax. While it thought that CT-guided should be avoided in patients with emphysema, however, there no scientific report documenting the relationship occurrence of pneumothorax and severity emphysema.To investigate between emphysema frequency pneumothorax, we retrospectively reviewed all who received biopsy. Severity evaluated by Goddard...
Activation of airway smooth muscle (ASM) cells plays a central role in the pathophysiology asthma. Because ASM is an important therapeutic target asthma, it beneficial to develop bioengineered models available for assessing physiological and biophysical properties cells. In condition vivo, are surrounded by extracellular matrix (ECM) exposed mechanical stresses such as cyclic stretch. We utilized 3-D culture model human embedded type-I collagen gel. further examined effects stretch, which...
BACKGROUND--Beta 2 adrenergic dysfunction may be one of the underlying mechanisms responsible for atopy and bronchial asthma. The gene encoding human beta receptor (beta 2ADR) has recently been isolated sequenced. In addition, a two allele polymorphism this identified in white people. A study was carried out to determine whether is functionally important any relation airways responsiveness, atopy, or METHODS--The subjects studied were 58 family members four patients with atopic Restriction...
Genetic factors are important in defining total serum IgE levels. Linkage analyses have localized a gene or genes that influence atopic phenotype at chromosome 11q13. Variants of the FCER1B been identified, which associated with an increased risk developing atopy and bronchial asthma. Given uncertain functional consequences low frequencies these coding variants FCER1B, we screened for new mutations using 24 subjects A common − 109C/T polymorphism promoter region was although no variant found...