A5058885400- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Asthma and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- Medical Imaging and Pathology Studies
- AI in cancer detection
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Pneumonia and Respiratory Infections
- Respiratory Support and Mechanisms
- Pleural and Pulmonary Diseases
- Neuroscience of respiration and sleep
- Pneumocystis jirovecii pneumonia detection and treatment
- Neonatal Respiratory Health Research
- Sarcoidosis and Beryllium Toxicity Research
- Metastasis and carcinoma case studies
- Nosocomial Infections in ICU
- COVID-19 diagnosis using AI
- Obstructive Sleep Apnea Research
Fujita Health University
2016-2025
Fujita Health University Hospital
2015-2024
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Respiratory Clinical Trials
2021-2022
Gunma University Hospital
2021
Kyoto University
2021
Kyocera (Japan)
2020-2021
Japan Broadcasting Corporation (Japan)
2021
Yole Développement (France)
2021
The pathological hallmark lesions in idiopathic pulmonary fibrosis are the fibroblastic foci, which fibroblasts thought to be involved tissue remodeling, matrix deposition, and cross-talk with alveolar epithelium. Recent evidence indicates that some may derived from bone marrow progenitors as well epithelial cells through epithelial-mesenchymal transition. To evaluate whether endothelial could represent an additional source for fibroblasts, bleomycin-induced lung was established...
Recent advances in bronchoscopy, such as transbronchial biopsy (TBB) using endobronchial ultrasonography with a guide sheath (EBUS-GS), have improved the diagnostic yield of small-sized peripheral lung lesions. In some cases, however, it is difficult to obtain adequate samples for pathological diagnosis. Adequate prediction accuracy TBB EBUS-GS important before deciding whether bronchoscopy should be performed.We retrospectively reviewed 149 consecutive patients who underwent lesions (≤30 mm...
Cytology is the first pathological examination performed in diagnosis of lung cancer. In our previous study, we introduced a deep convolutional neural network (DCNN) to automatically classify cytological images as with benign or malignant features and achieved an accuracy 81.0%. To further improve DCNN's performance, it necessary train using more images. However, difficult acquire cell which contain various use many manual operations microscope. Therefore, this aim classification DCNN actual...
Lung cancer is a leading cause of death worldwide, and its early detection usually performed with low-dose computed tomography. For lesions suspected abnormality by CT examination, cytological diagnosis lung cells collected biopsy first performed. However, atypical are the major challenge in malignant cell classification for cytotechnologists cytopathologists. In this study, we aimed to automatize from microscopic images using deep convolutional neural network (DCNN). Cytological specimens...
Lung cancer is a leading cause of death worldwide. Although computed tomography (CT) examinations are frequently used for lung diagnosis, it can be difficult to distinguish between benign and malignant pulmonary nodules on the basis CT images alone. Therefore, bronchoscopic biopsy may conducted if malignancy suspected following examinations. However, biopsies highly invasive, patients with undergo many unnecessary biopsies. To prevent this, an imaging diagnosis high classification accuracy...
Summary Purpose Anticancer agents are known to increase cancer-associated thrombosis (CAT) onset. CAT onset rate is reported be 1.92% in cisplatin-based therapy, 6.1% paclitaxel plus ramucirumab combination and 11.9% bevacizumab monotherapy. Because immune checkpoint inhibitors (ICIs) cause a sudden T cell number, an association between administration of these drugs incidence likely. However, the extent which ICI affects remains unclear. Further, risk factors for have not yet been...
Reverse transcription loop-mediated isothermal amplification (RT-LAMP) has been validated to diagnose several viral infections. However, its diagnostic accuracy in detecting SARS-CoV-2 real-life clinical settings remains unclear. This study aimed determine the sensitivity and specificity of RT-LAMP compared reverse transcription-quantitative polymerase chain reaction (RT-qPCR) over disease course COVID-19.
Aberrant immune responses to viral pathogens contribute pathogenesis, but our understanding of pathological caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019...
The initial assessment of the severity community-acquired pneumonia (CAP) is important for patient management. Japanese Respiratory Society (JRS) has proposed a 6-point scale (0-5) to assess clinical CAP. A-DROP scoring system assesses following parameters: (i) Age (male >or= 70 years, female 75 years); (ii) Dehydration (blood urea nitrogen (BUN) 210 mg/L); (iii) failure (SaO(2) <or= 90% or PaO(2) 60 mm Hg); (iv) Orientation disturbance (confusion); and (v) low blood Pressure (systolic...
Quercetin is a flavonoid with wide variety of cytoprotective and modulatory functions. Heme oxygenase-1 (HO-1) an inducible enzyme. Its reaction product, carbon monoxide (CO), confers cellular protection in number conditions diseases associated oxidative or inflammatory lung injury. Furthermore, quercetin was reported to be potent inducer HO-1 several cell types. We hypothesized that suppresses the production collagen fibroblasts via induction HO-1. Here, we showed transforming growth...
Abstract Background Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1) are used for the treatment of various cancer types. However, immune-related adverse events (irAEs) occur in patients treated with ICIs. Several small-scale studies have reported onset irAEs and therapeutic effects Here we report a large-scale retrospective study covering wide range cancers. We evaluated ICIs determined whether could be predicted. Methods This included anti-PD-1 antibodies...
Artificial intelligence (AI) applications in medical imaging continue facing the difficulty collecting and using large datasets. One method proposed for solving this problem is data augmentation fictitious images generated by generative adversarial networks (GANs). However, applying a GAN as technique has not been explored, owing to quality diversity of images. To promote such generating diverse images, study aims generate free-form lesion from tumor sketches pix2pix-based model, which an...
Abstract Pulmonary alveolar proteinosis (PAP) is a devastating lung disease caused by abnormal surfactant homeostasis, with prevalence of 6–7 cases per million population worldwide. While mutations causing hereditary PAP have been reported, the genetic basis contributing to autoimmune (aPAP) has not thoroughly investigated. Here, we conducted genome-wide association study aPAP in 198 patients and 395 control participants Japanese ancestry. The common variant, rs138024423 at 6p21,...
Activating mutations of EGFR are found frequently in a subgroup patients with non‐small cell lung cancer (NSCLC) and highly correlated the response to gefitinib erlotinib. In present study, we searched for , HER2 KRAS 264 resected primary NSCLC from Japanese determined whether there is correlation between genetic alterations these genes clinicopathological factors, together 85 tumors that reported previously. were 102 total 349 tumors, seven had two missense mutations. Reverse...
Objective Endobronchial ultrasonography with a guide sheath (EBUS-GS) and virtual bronchoscopic navigation (VBN) improves the diagnostic yield in patients peripheral pulmonary lesions (PPLs). Most previous reports on EBUS-GS-guided transbronchial biopsy (TBB) have included benign malignant diseases. We aimed to determine factors that predicted successful diagnosis by TBB small lung cancer, focus high-resolution computed tomography (HRCT) findings before bronchoscopy. Methods retrospectively...
Background: The chronic obstructive pulmonary disease (COPD) assessment test (CAT) is a short questionnaire that has facilitated health status measurements in subjects with COPD. However, it remains controversial as to whether the CAT can be used suitable substitute for St George’s Respiratory Questionnaire (SGRQ). This study investigated reliability and score distributions of SGRQ evaluated which factors contributed each questionnaire. Methods: A total 109 consecutive stable COPD from...
Cytology plays a crucial role in lung cancer diagnosis. Pulmonary cytology involves cell morphological characterisation the specimen and reporting corresponding findings, which are extremely burdensome tasks. In this study, we propose technique to generate cytologic findings from for images assist of pulmonary cytology. For 801 patch were retrieved using specimens collected 206 patients; assigned each image as dataset generating findings. The proposed method consists vision model dual text...
Between January 2022 and December 2023, the Toshiwakai long-term care facility (LTCF) experienced a COVID-19 cluster. Among 231 infected residents, 253 episodes were identified, including 20 residents who reinfected once one was twice. The strict infection control operation antiviral treatments promptly administered; however, four died, five hospitalized within 10 days (two due to fractures). Most symptomatic cases resolved days. A comparison of mortality rates between uninfected showed no...