A5069869654- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Gut microbiota and health
- Vasculitis and related conditions
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Bacteriophages and microbial interactions
- interferon and immune responses
- NF-κB Signaling Pathways
- Mycobacterium research and diagnosis
- Bone and Joint Diseases
- Clostridium difficile and Clostridium perfringens research
- Epigenetics and DNA Methylation
- Tuberculosis Research and Epidemiology
- Inflammation biomarkers and pathways
- Viral gastroenteritis research and epidemiology
- Autoimmune and Inflammatory Disorders Research
- IL-33, ST2, and ILC Pathways
- Ocular Diseases and Behçet’s Syndrome
- Dermatological and Skeletal Disorders
- Chronic Lymphocytic Leukemia Research
- Leptospirosis research and findings
- Inflammatory Myopathies and Dermatomyositis
- Ginseng Biological Effects and Applications
Osaka University
2019-2025
Osaka International University
2024
Osaka Minami Medical Center
2016-2020
Kumamoto University
2020
The causality and pathogenic mechanism of microbiome composition remain elusive in many diseases, including autoimmune diseases such as rheumatoid arthritis (RA). This study aimed to elucidate gut microbiome's role RA pathology by a comprehensive metagenome-wide association (MWAS).We conducted MWAS the Japanese population (ncase=82, ncontrol=42) using whole-genome shotgun sequencing high depth (average 13 Gb per sample). Our consisted three major bioinformatic analytic pipelines...
Objectives Prevotella copri is considered to be a contributing factor in rheumatoid arthritis (RA). However, some non-Westernised countries, healthy individuals also harbour an abundance of P. the intestine. This study investigated pathogenicity RA patient-derived ( ) compared with control-derived HC ). Methods We obtained 13 P . strains from faeces patients and controls. Following whole genome sequencing, sequences were compared. To analyse arthritis-inducing ability , we examined two...
Objective Alteration of the gut microbiome has been linked to pathogenesis systemic lupus erythematosus (SLE). However, a comprehensive view in SLE and its interaction with host remains be revealed. This study aimed reveal SLE-associated changes by metagenome-wide association (MWAS) followed integrative analysis. Methods We performed MWAS based on shotgun sequencing microbial DNA from Japanese individuals ( N case =47, control =203). integrated result genome-wide (GWAS) data plasma...
Autoimmune and allergic diseases are outcomes of the dysregulation immune system. Our study aimed to elucidate differences or shared components in genetic backgrounds between autoimmune diseases.
Abstract Human DNA present in faecal samples can result a small number of human reads gut shotgun metagenomic sequencing data. However, it is presently unclear how much personal information be reconstructed from such reads, and this has not been quantitatively evaluated. Such quantitative evaluation necessary to clarify the ethical concerns related data sharing enable efficient use genetic stool samples, as for research forensics. Here we used genomic approaches reconstruct metagenomes 343...
Aberrant immune responses to viral pathogens contribute pathogenesis, but our understanding of pathological caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019...
Objective The relationship between autoimmune diseases and the gut microbiome has been intensively studied, several autoimmunity-associated bacterial taxa have identified. However, much less is known about roles of virome in diseases. Methods Here, we performed a whole analysis based on shotgun sequencing 476 Japanese which included patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis healthy control subjects. Results Our case–control comparison...
T cells differentiate into highly diverse subsets and display plasticity depending on the environment. Although lymphocytes are key mediators of inflammation, functional specialization in inflammatory bowel disease (IBD) has not been effectively described. Here, we performed deep profiling intestinal mucosa IBD identified a CD4 + tissue-resident memory cell (Trm) subset that is increased Crohn’s (CD) showing unique properties. Functionally transcriptionally distinct Trm observed inflamed gut...
Abstract Background The impact of SARS-CoV-2 infection on the gut fungal (mycobiota) and bacterial (microbiota) communities has been elucidated individually. This study analyzed both mycobiota microbiota their correlation in COVID-19 patients with severe mild conditions follow-up to monitor alterations after recovery. Methods We by 16S ITS1 metagenomic sequencing 40 patients, 38 30 healthy individuals reanalyzed those 10 approximately 6 months discharge. Results groups showed lower diversity...
Peripheral neuropathy is a complication in systemic sclerosis that occasionally encountered clinical settings. The mechanisms underlying this condition remain unclear and treatment strategies have not yet been established, making management challenging. Here, we report case of peripheral associated with was successfully treated corticosteroid therapy despite the absence conventional inflammatory findings on histopathology or blood tests. A 44-year-old Japanese man diagnosed presented...
The intestinal lumen is rich in gut microbial metabolites that serve as signaling molecules for immune cells. G-protein-coupled receptors (GPCRs) sense and can act key mediators translate luminal signals into host responses. However, the impacts of microbe–GPCR interactions on human physiology have not been fully elucidated. Here, we show GPR31, which activated by bacterial metabolite pyruvate, specifically expressed type 1 conventional dendritic cells (cDC1s) lamina propria intestine. Using...
Interaction between the gut microbiome and host plays a key role in human health. Here, we perform metagenome shotgun-sequencing-based analysis of Japanese participants to reveal associations microbiome, genetics, plasma metabolome. A genome-wide association study (GWAS) for microbial species (n = 524) identifies PDE1C gene locus Bacteroides intestinalis TGIF2 TGIF2-RAB5IF loci acidifiaciens. In ortholog GWAS, agaE agaS, which are related metabolism carbohydrates forming blood group antigen,...
A 26-year-old woman with Takayasu's arteritis (TAK) experienced back and neck pain during tocilizumab (TCZ) treatment. The levels of C-reactive protein were normal, ultrasonography revealed no significant changes. Diffusion-weighted whole-body imaging background body signal suppression (DWIBS) showed enhancement in the walls several arteries. Contrast computed tomography arterial inflammation same lesion. After increasing dose prednisolone TCZ, all enhancements decreased continued to...
Infection is a serious complication observed in the management of rheumatoid arthritis (RA) patients. The acute inflammatory marker C-reactive protein (CRP) elevated both during infection and high disease activity RA, this often poses problem when distinguishing two. While markers should be measured quickly inexpensively simple matter, there also need to distinguish them from RA clinical practice. Recently, usefulness subtype soluble CD14, presepsin (P-SEP), has been reported critical care...
A 72-year-old man presented with persistent oligoarthritis and positive results for rheumatoid factor was suspected of having arthritis (RA). However, the musculoskeletal ultrasonography (MSUS) findings were not consistent those typical RA. He had undergone surgery carpal tunnel syndrome, which allowed both histopathological microbiological examinations to be performed. synovial tissue culture Sporothrix schenckii, he diagnosed sporotrichal tenosynovitis. received anti-fungal therapy,...
A 66-year-old woman with symptoms of fatigue and headache was diagnosed giant cell arteritis (GCA). Fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed (CT) revealed the strong accumulation FDG in descending aorta, abdominal bilateral subclavian artery, total iliac artery. Diffusion-weighted whole-body imaging background body signal suppression (DWIBS) showed enhancement at aorta aorta. We repeated FDG-PET DWIBS 2 months after initiation therapy prednisolone. In line...
Journal Article Pathological assessment of the lymph node biopsies for lymphadenopathy in rheumatoid arthritis Get access Chika Yamada, Yamada Department Rheumatology, National Hospital Organization, Osaka-Minami Medical Center, Osaka, Japan; Search other works by this author on: Oxford Academic Google Scholar Eri Oguro, Oguro Soichiro Tsuji, Tsuji Eriko Kudo-Tanaka, Kudo-Tanaka Satoru Teshigawara, Teshigawara Shiro Ohshima, Ohshima Jun Hashimoto, Hashimoto Yukihiko Saeki, Saeki Tetsuya...
<h3>Background</h3> Tocilizumab (TCZ), an inhibitor of interleukin-6 (IL-6), has been widely used to treat rheumatic diseases such as rheumatoid arthritis (RA) and juvenile idiopathic arthritis. Recently, TCZ was approved for use in patients with giant cell aortitis Takayasu aortitis. However, treatment sometimes obscures changes the conventional biomarkers infection serum levels C-reactive protein (CRP) procalcitonin (PCT). Presepsin (P-SEP), a subtype soluble CD14, recently identified...
<h3>Background and aims</h3> Lupus nephritis (LN) is one of the most serious clinical manifestations systemic lupus erythematosus (SLE). Recently, we have reported that expression levels CD64 on monocyte (mCD64), a high-affinity receptor for IgG (FcgRI), correlate with disease activity SLE (Lupus 2015;24:1076–80). However, relation between mCD64 yet to be elucidated. The aim this study investigate whether or not level correlates LN. <h3>Methods</h3> We quantitatively measured by flow...