A5055790903- Laser-Plasma Interactions and Diagnostics
- Laser-induced spectroscopy and plasma
- Magnetic confinement fusion research
- Particle Accelerators and Free-Electron Lasers
- Rheumatoid Arthritis Research and Therapies
- Particle accelerators and beam dynamics
- Multiple Myeloma Research and Treatments
- Laser-Matter Interactions and Applications
- Systemic Lupus Erythematosus Research
- Gyrotron and Vacuum Electronics Research
- Autoimmune and Inflammatory Disorders Research
- Plasma Diagnostics and Applications
- Laser Design and Applications
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Systemic Sclerosis and Related Diseases
- Advanced X-ray Imaging Techniques
- Atomic and Molecular Physics
- Superconducting Materials and Applications
- Terahertz technology and applications
- Immunotherapy and Immune Responses
- High-pressure geophysics and materials
- Spondyloarthritis Studies and Treatments
- Photocathodes and Microchannel Plates
- Plasma Applications and Diagnostics
Osaka University
2012-2021
Osaka Police Hospital
2019-2021
Osaka Hospital
2015-2019
NTT WEST Osaka Hospital
2016-2019
Takeda (Japan)
2015
National Hospital Organization
2015
Tohoku University Hospital
2015
Saitama Medical University
2015
Hamamatsu University School of Medicine
2015
Osaka City University
2015
Abstract IL-6 mediates growth of some human multiple myeloma (MM) cells and IL-6-dependent cell lines. Although three signaling pathways (STAT1, STAT3, Ras-dependent MAPK cascade) have been reported, cascades mediating IL-6-triggered MM lines are not defined. In this study, we therefore characterized in lines, patient cells, B9 to determine which pathway growth. induced phosphorylation JAK kinases gp130, regardless the proliferative response factor. Accordingly, next examined downstream via...
The causality and pathogenic mechanism of microbiome composition remain elusive in many diseases, including autoimmune diseases such as rheumatoid arthritis (RA). This study aimed to elucidate gut microbiome's role RA pathology by a comprehensive metagenome-wide association (MWAS).We conducted MWAS the Japanese population (ncase=82, ncontrol=42) using whole-genome shotgun sequencing high depth (average 13 Gb per sample). Our consisted three major bioinformatic analytic pipelines...
A laser pulse with a power of $\ensuremath{\sim}3$ TW and duration 1 ps has been focused onto gas. Ultrahigh-gradient electron acceleration observed in the laser-produced plasma density $\ensuremath{\sim}{10}^{19}$ c${\mathrm{m}}^{--3}$ when injecting MeV $/c$ electrons. The simulation laser-plasma interaction revealed existence ultrahigh-gradient wake fields excited due to self-modulation its acceleration, consistent experimental results.
Background Hypoxic and ischemic stresses cause a series of well-documented changes in myocardial cells tissues, including loss contractility, lipid fatty acid metabolism, irreversible membrane damage leading to eventual cellular death. Activated neutrophils are considered be involved this injury. By stimulation the with chemotactic factors, canine can induced adhere isolated cardiac myocytes only if have been previously exposed cytokines such as tumor necrosis factor–α, interleukin (IL)-1,...
Objective. SSc is an autoimmune disease characterized by fibrosis of the skin and internal organs. Although aetiology remains uncertain, many reports have suggested that IL-6 involved in pathogenesis. Tocilizumab, anti-IL-6 receptor antibody, anti-arthritis medicine works through blockade functions. To examine effect tocilizumab on SSc, we administered to two patients. Methods. Two dcSSc patients were at 8 mg/kg once a month for 6 months. One patient had pulmonary assessed CT spirometry,...
<h3>Objective</h3> To identify a novel serum biomarker of disease activity in inflammatory autoimmune disorders. <h3>Methods</h3> Sera obtained from rheumatoid arthritis (RA) patients before and after anti-TNF therapy were analysed by iTRAQ (isobaric tags for relative absolute quantitation) quantitative proteomic analysis further validated ELISA. <h3>Results</h3> Of 326 proteins identified analysis, increased levels leucine-rich α-2 glycoprotein (LRG) was RA therapy. Serum LRG concentrations...
To evaluate the efficacious noninferiority of subcutaneous tocilizumab injection (TCZ-SC) monotherapy to intravenous TCZ infusion (TCZ-IV) in Japanese patients with rheumatoid arthritis (RA) an inadequate response synthetic and/or biologic disease-modifying antirheumatic drugs (DMARDs).This study had a double-blind, parallel-group, double-dummy, comparative phase III design. Patients were randomized receive TCZ-SC 162 mg every 2 weeks or TCZ-IV 8 mg/kg 4 weeks; no DMARDs allowed during...
Objective Subcutaneous (SC) and intravenous formulations of tocilizumab (TCZ) are available for the treatment patients with rheumatoid arthritis (RA), based on efficacy safety observed in clinical trials. Anti-TCZ antibody development its impact were evaluated adult RA treated TCZ (TCZ-IV) or TCZ-SC as monotherapy combination conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). Methods Data from 5 8 TCZ-IV phase III trials 1 pharmacology study (>50 000 samples) pooled...
We analyzed the stimulatory effect of oncostatin M (OSM), leukemia inhibitory factor (LIF), interleukin 6 (IL-6), IL-11, and anti-IL-6 antibody (Ab), receptor monoclonal (mAb), anti-gp130 mAb on growth human plasmacytoma cells freshly isolated from a patient with multiple myeloma. The purified showed plasmacytoid morphology expressed CD38, CD54, CD56 antigens but no CD3, CD5, CD10, CD19, CD20, or very late antigen 5. IL-6 (IL-6R) its signal transducer, gp130, were their cell surface at low...
A 47-year-old female patient with Behçet's disease had been treated colchicine, prednisolone, cyclosporine A, and infliximab. Because she relapsed, however, treatment tocilizumab, a humanized anti-interleukin 6 receptor antibody, was started. This suppressed the patient's clinical manifestations, including ocular attacks, for 1 year improved her visual acuity. experience indicates that tocilizumab may constitute therapeutic option refractory disease.
Semaphorin 4D (Sema4D)/CD100 has pleiotropic roles in immune activation, angiogenesis, bone metabolism, and neural development. We undertook this study to investigate the role of Sema4D rheumatoid arthritis (RA).Soluble (sSema4D) levels serum synovial fluid were analyzed by enzyme-linked immunosorbent assay. Cell surface expression transcripts peripheral blood cells from RA patients, immunohistochemical staining was performed synovium. Generation sSema4D evaluated an ADAMTS-4-treated...